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EBAR SIGNED

Evidence Based Planning of Future Clinical Research

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EBAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BERN 

Organization address
address: HOCHSCHULSTRASSE 6
city: BERN
postcode: 3012
website: http://www.unibe.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.ispm.unibe.ch/research/research_groups/evidence_synthesis_methods/evidence_based_planning_of_clinical_research/index_eng.html
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 187˙419.00

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 Project objective

Clinical studies that are planned without prior consideration of existing evidence potentially experiment with an unnecessarily large number of patients or try to answer a question to which the answer is already available. This project aims to develop a framework of efficient and sustainable research planning that minimizes cost and has the potential to direct resource allocation by optimally planning future clinical studies based on existing evidence. A circular updating process is suggested; before a trial is planned the existing evidence (a network meta-analysis) about the effectiveness of all competing interventions is considered and its conclusiveness is statistically evaluated. If further experiments are needed these are designed considering patient’s preferences and with an aim to render the existing evidence conclusive. The new data is then used to update the existing knowledge. This innovative approach to plan clinical studied requires methodological developments from various fields (biostatistics, operational research, epidemiology) and its feasibility will be evaluated in answering a real clinical question about the best intervention for a given condition and in designing a new trial. The circular updating process is of high interest to public research funding bodies, guideline developers and pharmaceutical companies. The project has a strong public engagement component as patients and major health care organizations are involved in many of the planned activities in the development of the circular updating process. The project will be carried out in a stimulating academic environment (University of Bern) with extensive experience in clinical trials and a secondment in Novartis is planned. I will acquire technical skills in clinical trials, will continue to produce high-impact publications and develop leadership skills. These additions to my curriculum will enable me to progress to an academic carrier in a high-profile European Institute.

 Publications

year authors and title journal last update
List of publications.
2018 Georgia Salanti, Adriani Nikolakopoulou, Alex J. Sutton, Stephan Reichenbach, Sven Trelle, Huseyin Naci, Matthias Egger
Planning a future randomized clinical trial based on a network of relevant past trials
published pages: , ISSN: 1745-6215, DOI: 10.1186/s13063-018-2740-2
Trials 19/1 2019-06-13
2018 Adriani Nikolakopoulou, Dimitris Mavridis, Toshi A Furukawa, Andrea Cipriani, Andrea C Tricco, Sharon E Straus, George C M Siontis, Matthias Egger, Georgia Salanti
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
published pages: k585, ISSN: 0959-8138, DOI: 10.1136/bmj.k585
BMJ 2019-06-13
2018 Matthew K Bagg, Georgia Salanti, James H McAuley
Research Note: Comparing interventions with network meta-analysis
published pages: 128-132, ISSN: 1836-9553, DOI: 10.1016/j.jphys.2018.02.014
Journal of Physiotherapy 64/2 2019-06-13
2018 Richard D Riley, Dan Jackson, Georgia Salanti, Danielle L Burke, Malcolm Price, Jamie Kirkham, Ian R White
Multivariate and network meta-analysis of multiple outcomes and multiple treatments: rationale, concepts, and examples
published pages: j3932, ISSN: 0959-8138, DOI: 10.1136/bmj.j3932
BMJ 2019-06-13
2018 Marcel Zwahlen, Geogia Salanti
Causal inference from experiment and observation
published pages: 34-38, ISSN: 1362-0347, DOI: 10.1136/eb-2017-102859
Evidence Based Mental Health 21/1 2019-06-13
2018 George CM Siontis, Dimitris Mavridis, John P Greenwood, Bernadette Coles, Adriani Nikolakopoulou, Peter Jüni, Georgia Salanti, Stephan Windecker
Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials
published pages: k504, ISSN: 0959-8138, DOI: 10.1136/bmj.k504
BMJ 2019-06-13
2016 A. Nikolakopoulou, D. Mavridis, M. Egger, G. Salanti
Continuously updated network meta-analysis and statistical monitoring for timely decision-making
published pages: , ISSN: 0962-2802, DOI: 10.1177/0962280216659896
Statistical Methods in Medical Research 2019-06-13
2016 Toshi A Furukawa, Andrea Cipriani, Lauren Z Atkinson, Stefan Leucht, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Anna Chaimani, Georgia Salanti
Placebo response rates in antidepressant trials: a systematic review of published and unpublished double-blind randomised controlled studies
published pages: 1059-1066, ISSN: 2215-0366, DOI: 10.1016/S2215-0366(16)30307-8
The Lancet Psychiatry 3/11 2019-06-13
2018 Alessandro Pompoli, Toshi A. Furukawa, Orestis Efthimiou, Hissei Imai, Aran Tajika, Georgia Salanti
Dismantling cognitive-behaviour therapy for panic disorder: a systematic review and component network meta-analysis
published pages: 1-9, ISSN: 0033-2917, DOI: 10.1017/S0033291717003919
Psychological Medicine 2019-06-13
2018 Adriani Nikolakopoulou, Sven Trelle, Alex J Sutton, Matthias Egger, Georgia Salanti
Synthesizing existing evidence to design future trials: survey of methodologists in Europe
published pages: , ISSN: , DOI:
online/ submitted to Trials 2019-06-13
2016 Maria Petropoulou, Adriani Nikolakopoulou, Areti-Angeliki Veroniki, Patricia Rios, Afshin Vafaei, Wasifa Zarin, Myrsini Giannatsi, Shannon Sullivan, Andrea C. Tricco, Anna Chaimani, Matthias Egger, Georgia Salanti
Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015
published pages: , ISSN: 0895-4356, DOI: 10.1016/j.jclinepi.2016.11.002
Journal of Clinical Epidemiology 2019-06-13

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