CAP-CANCER
Cold atmospheric plasma treatment for effective cancer cell apoptosis
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the CAP-CANCER project. It provides you a very rough idea of what is the project "CAP-CANCER" about.
Project "CAP-CANCER" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY OF CYPRUS
Organization address contact info |
| Coordinator Country | Cyprus [CY] |
| Project website | http://www.enal.ucy.ac.cy/projects/capcancer/ |
| Total cost | 163˙648 € |
| EC max contribution | 163˙648 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2018-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY OF CYPRUS | CY (NICOSIA) | coordinator | 163˙648.00 |
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Project objective
Cold atmospheric plasma (CAP) has shown promise in minimally invasive surgery by selectively treating cancerous cells with little or no damage to healthy cells. The selective destruction of cancerous cells can be used to aid and enhance current cancer treatments and can also be the cure for forms of inoperable cancer. The selective treatment can be obtained by using the plasma to induce cell apoptosis, in which the cell self-destructs in a tightly controlled way without causing inflammation in the surrounding tissue. One of the major challenges of this research is that the exact mechanism of plasma induced apoptosis is not well understood. The fellow proposes to test the hypothesis CAP builds up electric fields across the cell membrane that cause electroporation for the cancerous but not the healthy cell because they have different electrical and physical properties. Electroporation allows for the penetration of reactive oxygen species (ROS) into the cancerous cell causing apoptosis while leaving the healthy cells intact. The fellow will develop numerical simulations to allow the study of cell surface electric fields and generation of ROS will explore the parameter space in which the electroporation and therefore apoptosis will be induced only for the cancerous cells. During his secondment the Fellow will perform experiments by applying CAP onto two Breast cell lines: MDA-MB-231 (cancerous) MCF-12F (healthy) and will use flow cytometry to measure electroporation and apoptosis. The results of this research will elucidate how CAP interacts with tissue and under what conditions it causes apoptosis. This will allow us to get closer to an actual medical device utilizing CAP to treat cancer on patients. The fellow will gain scientific skills in cell culture handling, storing, preparation, plasma sources and characterization and complementary skills and will reach a position of professional maturity and leadership in research and development in Europe.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
C Lazarou, C Anastassiou, I Topala, A S Chiper, I Mihaila, V Pohoata, G E Georghiou Numerical simulation of capillary helium and helium−oxygen atmospheric pressure plasma jets: propagation dynamics and interaction with dielectric published pages: 105007, ISSN: 1361-6595, DOI: 10.1088/1361-6595/aadeb8 |
Plasma Sources Science and Technology 27/10 | 2019-05-28 |
| 2017 |
Constantinos Lazarou, Alina Chiper, Charalambos Anastassiou, Valey Pohoata, Ilarion Mihaila, Ionut Topala, George E. Georghiou Numerical and experimental investigation of the effect of N2 and O2 admixtures in a helium dielectric barrier discharge published pages: 65, ISSN: , DOI: |
17th INTERNATIONAL CONFERENCE ON PLASMA PHYSICS AND APPLICATIONS | 2019-05-28 |
| 2017 |
Constantinos Lazarou,Charalambos Anastassiou, Ionut Topala, Alina Chiper, Ilarion Mihaila, Valey Pohoata, George E. Georghiou The effect of oxygen impurities of helium atmospheric pressure plasma jet on the redox chemistry of cells published pages: , ISSN: , DOI: |
Frontiers in redox biology and chemistry, young professionals workshop on plasma medicine | 2019-05-28 |
| 2017 |
Constantinos Lazarou, Charalambos Anastassiou, Ionut Topala, Alina Chiper, Ilarion Mihaila, Valey Pohoata, George E. Georghiou Numerical modelling of the effect of water admixtures in a helium/air parallel plate dielectric barrier discharge published pages: , ISSN: , DOI: |
Proceedings for ESCAMPIG XXIV, Glasgow, Scotland, July 17-21, 2018 | 2019-05-28 |
| 2017 |
Constantinos Lazarou, Charalambos Anastassiou, David Klute, Franzke Joachim, George E. Georghiou The influence of air impurities on the evolution of plasma species in a capillary helium plasma jet published pages: 308, ISSN: , DOI: |
Proceedings of the XXXIII INTERNATIONAL CONFERENCE ON PHENOMENA IN IONIZED GASES | 2019-05-28 |
| 2017 |
Charalambos Anastassiou, Constantinos Lazarou,Alina Chiper, Valey Pohoata, Ilarion Mihaila, Ionut Topala, George E. Georghiou Understanding the bullet evolution and its interaction with dielectricsin a capillary helium plasma jet published pages: 35, ISSN: , DOI: |
17th INTERNATIONAL CONFERENCE ON PLASMA PHYSICS AND APPLICATIONS Book of Abstracts | 2019-05-28 |
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