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CONtrast through metal-enriched polymer SALTs: novel contrast agents for dual-energy micro-computed tomography

Total Cost €


EC-Contrib. €






Project "CONSALT" data sheet

The following table provides information about the project.


Organization address
address: Arcisstrasse 21
postcode: 80333

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

X-ray micro computed tomography (microCT) is currently successfully used in material science investigations as well as in non-destructive testing enabling 3D imaging of these materials with micrometer resolution. The application of microCT for biological samples (e.g. biopsies) is limited by the missing contrast of soft tissue, which is important to visualize microscopic cellular structures. CONSALT aims at overcoming these limitations by simultaneous and yet separate visualization of a combination of at least two elements. Furthermore, it aims to advance x-ray microCT by allowing the visualization of single cells, which is currently not possible with the state-of-the-art x-ray microCT devices. The development and medicinal application of a fast X-ray based 3D-screening system for tissue biopsies to identify, visualize, and classify different pathologies, will complement conventional histology, which is based on the evaluation of a few selective 2D slices of a 3D biopsy, and further improve diagnosis (e.g. visualization of small tumors within the entire tissue volume or other 3D morphology parameters). Novel specific and functional contrast agents (stains) are essential to achieve the 3D visualization of specific pathological cellular or sub-cellular structures (e.g. nucleus or cytoskeleton). The design, development and testing of such new contrast agents to overcome the challenges of contrast enhancement and selectivity for certain tissue and cellular structures (e.g. nucleus, mitochondria or cytoplasm), which is seen through conventional staining in histology, is proposed here. The CT-contrast will be achieved by incorporation of biocompatible elements with a high z-component such as iodine and bismuth. The specific CT-contrast will be further optimized through dual-energy X-ray microCT-scanners allowing for visualization of at least two elements.


year authors and title journal last update
List of publications.
2017 Madleen Busse and Franz Pfeiffer
Novel heavy metal ion-hematein-complexes useful as ex vivo contrast agent for a computed tomography scanning of a biological sample, ex vivo method for investigating a biological sample, and use of the complexes (EP-Patent application 19 196 491.9)
published pages: , ISSN: , DOI:
2017 Madleen Busse and Franz Pfeiffer
Novel heavy metal ion-ligand-complexes useful as ex vivo contrast agent for a computed tomography scanning of a biological sample, ex vivo method for investigating a biological sample, and use of the complexes (EP-Patent application: 19 196 492.7)
published pages: , ISSN: , DOI:
2018 Madleen Busse, Mark Müller, Melanie A. Kimm, Simone Ferstl, Sebastian Allner, Klaus Achterhold, Julia Herzen, Franz Pfeiffer
Three-dimensional virtual histology enabled through cytoplasm-specific X-ray stain for microscopic and nanoscopic computed tomography
published pages: 2293-2298, ISSN: 0027-8424, DOI: 10.1073/pnas.1720862115
Proceedings of the National Academy of Sciences 115/10 2019-06-13

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