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SHIGETECVAX SIGNED

Early clinical development of a live, attenuated combination vaccine against Shigella and ETEC diarrhoea

Total Cost €

EC-Contrib. €

Partnership

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SHIGETECVAX project word cloud

Explore the words cloud of the SHIGETECVAX project. It provides you a very rough idea of what is the project "SHIGETECVAX" about.

oral trial infections rational first antigens sero invasiveness administration adults diarrhoea vaccines immunity antigen costly blocking pathogen huge vaccination protection shared closely clinical complementary ing antibodies too immune generations reactogenic material induce critical epidemiology radically invasion protecting gut surface solution manufacture mucosal endemic immunogenicity etec virulence molecular entails safety although advancing lmics efforts safer shigetec cell possibly almost disease human toxin designed vaccine recognition serotypes doses shigellosis detoxified pathogens neutralizing attenuated attempts expertise caused candidates additional lps disruption natural bangladesh live advantage failed immunodominant pillars elimination populations reduce shigella enteric multiple burden

Project "SHIGETECVAX" data sheet

The following table provides information about the project.

Coordinator	EUROPEAN VACCINE INITIATIVE EWIV Organization address address: VOSSSTRASSE 2 GEB 4040 city: HEIDELBERG postcode: 69115 website: http://www.euvaccine.eu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	0 €
EC max contribution	8˙603˙989 € (0%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2018-Two-Stage-RTD
Funding Scheme	RIA-LS
Starting year	2019
Duration (year-month-day)	from 2019-09-01 to 2024-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EUROPEAN VACCINE INITIATIVE EWIV EUROPEAN VACCINE INITIATIVE EWIV Organization address address: VOSSSTRASSE 2 GEB 4040 city: HEIDELBERG postcode: 69115 website: http://www.euvaccine.eu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	coordinator	359˙755.00
2	EVELIQURE BIOTECHNOLOGIES GMBH EVELIQURE BIOTECHNOLOGIES GMBH Organization address address: KARL-FARKAS-GASSE 22 city: WIEN postcode: 1030 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	5˙024˙401.00
3	INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH BANGLADESH Organization address address: SHAHEED TAJUDDIN AHMED SHARANI 68 city: DHAKA postcode: 1212 website: www.icddrb.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BD (DHAKA)	participant	1˙924˙713.00
4	GOETEBORGS UNIVERSITET GOETEBORGS UNIVERSITET Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 website: www.gu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOETEBORG)	participant	749˙842.00
5	PATH PATH Organization address address: 2201 WESTLAKE AVENUE, SUITE 200 city: SEATTLE postcode: 98121 2767 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (SEATTLE)	participant	545˙277.00

Map

Project objective

Although vaccination is an effective way to reduce the huge disease burden associated with diarrhoea caused by enteric pathogens, many attempts to develop vaccines for shigellosis and ETEC infections have failed and a number of current approaches are too complex and costly to provide an adequate solution for LMICs. This Consortium is dedicated to advancing a radically new approach against Shigella and ETEC based not on the immunodominant, but highly variable Shigella LPS O-antigen, target of almost all past and current vaccine development efforts. There are four pillars on which the ShigETEC vaccine has been designed: (i) Elimination of the LPS O-antigen to allow recognition of multiple antigens on the cell surface that are shared among different serotypes of Shigella and are increasingly being recognized as important in protection from shigellosis. These antigens are also closely related to those of ETEC and may also help in protecting against that pathogen as well. (ii) Elimination of the invasiveness of Shigella by disruption of the invasion complex resulting in a much safer/less reactogenic oral vaccine that can take advantage of gut mucosal immunity, possibly allowing administration of high vaccine doses and therefore addresses the low immunogenicity seen with other live attenuated vaccine candidates. (iii) Addition of detoxified toxin antigens of ETEC that will induce neutralizing/blocking antibodies to these critical virulence factors. (iv) Rational molecular design of ShigETEC will allow future generations of vaccines to include additional antigens for other pathogens. The work programme entails manufacture of clinical trial material, first-in-human testing for safety and immunogenicity in non-endemic adults, a sero-epidemiology study to learn about natural immune response to the vaccine, and importantly testing the vaccine in endemic populations. The Consortium comprises partners from EU and Bangladesh that bring along highly complementary expertise.

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The information about "SHIGETECVAX" are provided by the European Opendata Portal: CORDIS opendata.