Explore the words cloud of the MIRNANO project. It provides you a very rough idea of what is the project "MIRNANO" about.
The following table provides information about the project.
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
|Coordinator Country||Italy [IT]|
|Total cost||244˙269 €|
|EC max contribution||244˙269 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-01-15 to 2020-01-14|
Take a look of project's partnership.
|1||UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA||IT (ROMA)||coordinator||244˙269.00|
|2||THE REGENTS OF THE UNIVERSITY OF CALIFORNIA||US (OAKLAND CA)||partner||0.00|
WHAT: MIRNANO project is an interdisciplinary nanotechnology-driven program in which the fields of nanomaterial and DNA functional engineering are merged to develop innovative nanodevices for pluripotent targeted cancer treatment. The leading idea is to focus on aberrantly expressed microRNAs (miRNAs) as targets of the proposed therapeutic care, which allows for tailoring of the action to the genetic expression of a specific tumor. WHY: Current chemotherapy still relies on an untargeted paradigm, which suffers from poisoning side effects and lacks a focused action over the tumor area. Molecular biology has definitely demonstrated the pivotal role played by microRNAs in cancer development and metastasis progression, therefore anti-miR therapy is the ultimate strategy to bet on. Working at the nanoscale will allow to achieve advanced nanomaterials that can home to the specific tumor tissue and silence the aberrantly expressed miRNAs producing a downstream therapeutic effect. HOW: The proposed program is a very challenging project that aims to provide a groundbreaking contribution to cancer treatment. Nanomaterial science is primarily involved in this project. Porous silicon nanoparticles are intended to be used as luminescent, biodegradable, and biocompatible platforms for producing the anti-miR nanodevices. Functionalization with tumor-penetrating peptides will allow to achieve homing of the particles to the site of action, thus specifically targeting the tumor environment. Anti-miR nucleic acids, carried and delivered through the silicon nanocarriers, will ensure knockdown of target miRNAs, inducing downstream suppression of tumor growth. A complementary engineering of the anti-miR nucleic acid unit through rational design of advanced switching structures will allow for developing programmed miR-responsive tools, which are meant to reinforce the primary anti-miR effect with an extra-therapeutic action.
|year||authors and title||journal||last update|
Jonathan M. Zuidema, Alessandro Bertucci, Jinyoung Kang, Michael J. Sailor, Francesco Ricci
Hybrid polymer/porous silicon nanofibers for loading and sustained release of synthetic DNA-based responsive devices
published pages: 2333-2339, ISSN: 2040-3364, DOI: 10.1039/c9nr08474f
Alessandro Bertucci, Kang-Hoon Kim, Jinyoung Kang, Jonathan M. Zuidema, Seo Hyeon Lee, Ester J. Kwon, Dokyoung Kim, Stephen B. Howell, Francesco Ricci, Erkki Ruoslahti, Hyeung-Jin Jang, Michael J. Sailor
Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy
published pages: 23926-23937, ISSN: 1944-8244, DOI: 10.1021/acsami.9b07980
|ACS Applied Materials & Interfaces 11/27||2020-03-24|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MIRNANO" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MIRNANO" are provided by the European Opendata Portal: CORDIS opendata.
Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and IconographyRead More
How other minds are represented in the human brain: Neural computations underlying Theory of MindRead More
New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling.Read More