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MIRNANO SIGNED

Multifunctional miRNA-targeting nanodevices for pluripotent cancer theranostics

Total Cost €

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EC-Contrib. €

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Partnership

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 MIRNANO project word cloud

Explore the words cloud of the MIRNANO project. It provides you a very rough idea of what is the project "MIRNANO" about.

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Project "MIRNANO" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA 

Organization address
address: VIA CRACOVIA 50
city: ROMA
postcode: 133
website: www.uniroma2.it

contact info
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surname: n.a.
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 Coordinator Country Italy [IT]
 Project website http://www.francescoriccilab.com
 Total cost 244˙269 €
 EC max contribution 244˙269 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2017
 Duration (year-month-day) from 2017-01-15   to  2020-01-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA IT (ROMA) coordinator 244˙269.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

WHAT: MIRNANO project is an interdisciplinary nanotechnology-driven program in which the fields of nanomaterial and DNA functional engineering are merged to develop innovative nanodevices for pluripotent targeted cancer treatment. The leading idea is to focus on aberrantly expressed microRNAs (miRNAs) as targets of the proposed therapeutic care, which allows for tailoring of the action to the genetic expression of a specific tumor. WHY: Current chemotherapy still relies on an untargeted paradigm, which suffers from poisoning side effects and lacks a focused action over the tumor area. Molecular biology has definitely demonstrated the pivotal role played by microRNAs in cancer development and metastasis progression, therefore anti-miR therapy is the ultimate strategy to bet on. Working at the nanoscale will allow to achieve advanced nanomaterials that can home to the specific tumor tissue and silence the aberrantly expressed miRNAs producing a downstream therapeutic effect. HOW: The proposed program is a very challenging project that aims to provide a groundbreaking contribution to cancer treatment. Nanomaterial science is primarily involved in this project. Porous silicon nanoparticles are intended to be used as luminescent, biodegradable, and biocompatible platforms for producing the anti-miR nanodevices. Functionalization with tumor-penetrating peptides will allow to achieve homing of the particles to the site of action, thus specifically targeting the tumor environment. Anti-miR nucleic acids, carried and delivered through the silicon nanocarriers, will ensure knockdown of target miRNAs, inducing downstream suppression of tumor growth. A complementary engineering of the anti-miR nucleic acid unit through rational design of advanced switching structures will allow for developing programmed miR-responsive tools, which are meant to reinforce the primary anti-miR effect with an extra-therapeutic action.

 Publications

year authors and title journal last update
List of publications.
2020 Jonathan M. Zuidema, Alessandro Bertucci, Jinyoung Kang, Michael J. Sailor, Francesco Ricci
Hybrid polymer/porous silicon nanofibers for loading and sustained release of synthetic DNA-based responsive devices
published pages: 2333-2339, ISSN: 2040-3364, DOI: 10.1039/c9nr08474f
Nanoscale 12/4 2020-03-24
2019 Alessandro Bertucci, Kang-Hoon Kim, Jinyoung Kang, Jonathan M. Zuidema, Seo Hyeon Lee, Ester J. Kwon, Dokyoung Kim, Stephen B. Howell, Francesco Ricci, Erkki Ruoslahti, Hyeung-Jin Jang, Michael J. Sailor
Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy
published pages: 23926-23937, ISSN: 1944-8244, DOI: 10.1021/acsami.9b07980
ACS Applied Materials & Interfaces 11/27 2020-03-24

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The information about "MIRNANO" are provided by the European Opendata Portal: CORDIS opendata.

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