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CaLiAT

A novel pathway for generation of building blocks for antibiotic biosynthesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 CaLiAT project word cloud

Explore the words cloud of the CaLiAT project. It provides you a very rough idea of what is the project "CaLiAT" about.

fed    training    pool    bearing    substrates    engineering    newly    biology    gain    spread    published    ligase    polyketides    fatty    biochemical    resistance    confirm    efficient    bio    gene    actinomycete    ligases    leadership    routes    strategies    insights    drugs    family    engineered    significantly    acyltransferase    domains    secondly    humans    leads    precursors    rational    equip    bacteria    drug    antibiotic    building    divides    blocks    animals    sequence    realising    precursor    diversity    alteration    first    accept    experiencing    acids    sequencing    supplying    sustainable    dependent    recruit    acid    carboxylases    specificity    competitive    revival    cognate    databases    area    vitro    ways    carboxylase    offers    genome    unusual    assembly    extender    knockouts    examples    threat    biosynthetic    researcher    search    expand    strains    microorganisms    designed    additional    enzymes    candidate    structures    informatic    units    line    natural    time    biotin    biosynthesis    chemical    potentially    targetted    sought    acquire    analogues    substrate    polyketide    parts   

Project "CaLiAT" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

The development and spread of antibiotic resistance in microorganisms is a major threat to both humans and animals and the search for new and improved drugs is of high importance. Natural products are experiencing a strong revival as leads in drug development, and biosynthetic engineering offers sustainable routes to new and potentially improved analogues. Finding new ways to make these rational changes should ensure that the European Research Area remains competitive in realising the potential of this technology. The aim of this project is to gain a detailed understanding of a newly-identified family of enzymes supplying unusual fatty acid building blocks for assembly-line biosynthesis of natural products; and to exploit these insights to develop more efficient strategies for targeted alteration of their structures. The novel precursor enzymes to be studied, a ligase and a biotin-dependent carboxylase, are in pathways to several polyketides produced by actinomycete bacteria. The project divides into three parts. First, additional examples of the new pathway will be sought by targetted whole-genome sequencing, as well as bio-informatic analysis of published sequence databases, and gene knockouts used to confirm the role of the pathway in providing polyketide extender units. Secondly, candidate ligases, carboxylases and the cognate acyltransferase domains that specifically recruit the unusual extender units will be studied in vitro for substrate specificity and for their ability to accept non-natural substrates bearing chemical functionality. Finally, a range of non-natural fatty acids will be fed as precursors to engineered strains designed to produce novel polyketide analogues. This approach should significantly expand the available pool of polyketide diversity. At the same time, the researcher will acquire high-level training in biochemical and chemical biology approaches that will help equip her for a leadership role in research.

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The information about "CALIAT" are provided by the European Opendata Portal: CORDIS opendata.

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