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CaLiAT

A novel pathway for generation of building blocks for antibiotic biosynthesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 CaLiAT project word cloud

Explore the words cloud of the CaLiAT project. It provides you a very rough idea of what is the project "CaLiAT" about.

substrate    natural    researcher    diversity    divides    alteration    bacteria    databases    substrates    engineered    spread    significantly    accept    carboxylase    competitive    vitro    bearing    published    first    biology    family    acids    dependent    ligase    sequencing    pool    strains    resistance    specificity    realising    carboxylases    threat    ways    precursor    biosynthetic    extender    recruit    leads    unusual    secondly    targetted    animals    routes    examples    microorganisms    time    biotin    gene    biochemical    informatic    fed    polyketides    sequence    enzymes    cognate    leadership    polyketide    blocks    sustainable    drug    experiencing    revival    candidate    search    acquire    assembly    designed    newly    genome    knockouts    potentially    sought    insights    precursors    ligases    line    building    humans    drugs    domains    gain    bio    structures    strategies    equip    confirm    analogues    actinomycete    engineering    rational    fatty    supplying    chemical    parts    offers    acid    training    area    biosynthesis    efficient    expand    antibiotic    acyltransferase    additional    units   

Project "CaLiAT" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

The development and spread of antibiotic resistance in microorganisms is a major threat to both humans and animals and the search for new and improved drugs is of high importance. Natural products are experiencing a strong revival as leads in drug development, and biosynthetic engineering offers sustainable routes to new and potentially improved analogues. Finding new ways to make these rational changes should ensure that the European Research Area remains competitive in realising the potential of this technology. The aim of this project is to gain a detailed understanding of a newly-identified family of enzymes supplying unusual fatty acid building blocks for assembly-line biosynthesis of natural products; and to exploit these insights to develop more efficient strategies for targeted alteration of their structures. The novel precursor enzymes to be studied, a ligase and a biotin-dependent carboxylase, are in pathways to several polyketides produced by actinomycete bacteria. The project divides into three parts. First, additional examples of the new pathway will be sought by targetted whole-genome sequencing, as well as bio-informatic analysis of published sequence databases, and gene knockouts used to confirm the role of the pathway in providing polyketide extender units. Secondly, candidate ligases, carboxylases and the cognate acyltransferase domains that specifically recruit the unusual extender units will be studied in vitro for substrate specificity and for their ability to accept non-natural substrates bearing chemical functionality. Finally, a range of non-natural fatty acids will be fed as precursors to engineered strains designed to produce novel polyketide analogues. This approach should significantly expand the available pool of polyketide diversity. At the same time, the researcher will acquire high-level training in biochemical and chemical biology approaches that will help equip her for a leadership role in research.

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The information about "CALIAT" are provided by the European Opendata Portal: CORDIS opendata.

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