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Chromatin targeting and remodelling by bacterial effectors in plant immunity

Total Cost €


EC-Contrib. €






 CHERI project word cloud

Explore the words cloud of the CHERI project. It provides you a very rough idea of what is the project "CHERI" about.

heteromeric    circulating    hypothesize    infection    plants    mammals    environment    unclear    defence    bacterial    intracellular    basal    disseminate    components    chromatin    signalling    triggered    capacity    structurally    nature    sustainable    converge    elucidate    functional    viruses    histone    mechanisms    fundamental    domains    receptors    nuclear    unrelated    pathogen    connected    instead    activation    cell    encoding    human    molecular    interferes    machinery    plant    forms    mount    successful    suppress    pathogens    signals    converted    certain    lack    physically    immune    perturbations    causing    fungi    resistance    remodelling    found    disease    effectors    suggest    immunity    proteins    pair    effector    actions    overlapping    recognition    unlike    modulated    genes    innate    challenged    intercepted    bacteria    senses    virulence    probes    transduced    host    agriculture    interact    sites    underlying    health    receptor    modifications    arabidopsis    rely    systemic    perceive   

Project "CHERI" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

In nature, plants are challenged by disease-causing pathogens such as viruses, bacteria and fungi. Understanding mechanisms of plant disease and disease resistance is of fundamental importance to sustainable agriculture and human health. Unlike mammals, plants lack a circulating immune system. Plants instead rely on the innate immune capacity of each cell and systemic signals that disseminate from infection sites. Successful pathogens use effectors to suppress plant immunity and cause disease. Plants have evolved disease resistance genes encoding immune receptors that perceive specific pathogen effectors to mount effector-triggered immunity. In Arabidopsis, a heteromeric pair of intracellular immune receptors forms a functional recognition complex which senses virulence activities of two structurally unrelated bacterial effectors at the nuclear chromatin. Results suggest that effector targeting of histone modifications and chromatin remodelling interferes with host basal immunity and that this is transduced by the receptor pair to activation of defence pathways. The underlying molecular mechanisms remain unclear. We have found that the two bacterial effectors interact with an overlapping set of chromatin-associated proteins and with certain immune receptor domains. We hypothesize that the effectors converge on the same chromatin machinery for promoting disease and that their actions are intercepted by the immune receptor system which is physically connected to basal immunity signalling components. By using the effectors as molecular probes, this proposal aims to elucidate how the chromatin environment is modulated during infection and how effector perturbations are converted to effective immunity.

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The information about "CHERI" are provided by the European Opendata Portal: CORDIS opendata.

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