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Chromatin targeting and remodelling by bacterial effectors in plant immunity

Total Cost €


EC-Contrib. €






 CHERI project word cloud

Explore the words cloud of the CHERI project. It provides you a very rough idea of what is the project "CHERI" about.

plants    sites    host    successful    infection    cell    modulated    human    hypothesize    recognition    pathogens    found    molecular    senses    bacteria    proteins    nature    genes    health    disseminate    perceive    circulating    sustainable    heteromeric    forms    intracellular    triggered    encoding    receptor    resistance    underlying    unrelated    systemic    intercepted    effector    signalling    disease    domains    transduced    remodelling    instead    chromatin    nuclear    immunity    agriculture    converted    fungi    causing    basal    functional    unclear    unlike    rely    interact    pathogen    components    pair    virulence    overlapping    viruses    fundamental    perturbations    mechanisms    environment    interferes    suggest    immune    defence    innate    mammals    machinery    bacterial    modifications    converge    elucidate    challenged    arabidopsis    mount    plant    effectors    physically    structurally    suppress    receptors    lack    histone    activation    certain    actions    capacity    probes    connected    signals   

Project "CHERI" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

In nature, plants are challenged by disease-causing pathogens such as viruses, bacteria and fungi. Understanding mechanisms of plant disease and disease resistance is of fundamental importance to sustainable agriculture and human health. Unlike mammals, plants lack a circulating immune system. Plants instead rely on the innate immune capacity of each cell and systemic signals that disseminate from infection sites. Successful pathogens use effectors to suppress plant immunity and cause disease. Plants have evolved disease resistance genes encoding immune receptors that perceive specific pathogen effectors to mount effector-triggered immunity. In Arabidopsis, a heteromeric pair of intracellular immune receptors forms a functional recognition complex which senses virulence activities of two structurally unrelated bacterial effectors at the nuclear chromatin. Results suggest that effector targeting of histone modifications and chromatin remodelling interferes with host basal immunity and that this is transduced by the receptor pair to activation of defence pathways. The underlying molecular mechanisms remain unclear. We have found that the two bacterial effectors interact with an overlapping set of chromatin-associated proteins and with certain immune receptor domains. We hypothesize that the effectors converge on the same chromatin machinery for promoting disease and that their actions are intercepted by the immune receptor system which is physically connected to basal immunity signalling components. By using the effectors as molecular probes, this proposal aims to elucidate how the chromatin environment is modulated during infection and how effector perturbations are converted to effective immunity.

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The information about "CHERI" are provided by the European Opendata Portal: CORDIS opendata.

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