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CHERI

Chromatin targeting and remodelling by bacterial effectors in plant immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 CHERI project word cloud

Explore the words cloud of the CHERI project. It provides you a very rough idea of what is the project "CHERI" about.

nuclear    intracellular    interact    sustainable    forms    agriculture    successful    suppress    found    certain    nature    innate    actions    signals    lack    pathogen    unlike    resistance    cell    unclear    heteromeric    disseminate    causing    immune    pathogens    physically    elucidate    systemic    perturbations    genes    mount    health    fungi    recognition    suggest    mechanisms    capacity    sites    circulating    interferes    machinery    defence    effectors    senses    molecular    receptors    infection    functional    fundamental    modifications    challenged    structurally    converge    chromatin    plants    host    intercepted    environment    human    overlapping    modulated    activation    instead    transduced    remodelling    unrelated    connected    triggered    converted    hypothesize    pair    histone    viruses    effector    immunity    arabidopsis    bacterial    plant    virulence    disease    bacteria    domains    signalling    perceive    rely    receptor    proteins    components    underlying    probes    encoding    basal    mammals   

Project "CHERI" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.mpipz.mpg.de/parker
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

In nature, plants are challenged by disease-causing pathogens such as viruses, bacteria and fungi. Understanding mechanisms of plant disease and disease resistance is of fundamental importance to sustainable agriculture and human health. Unlike mammals, plants lack a circulating immune system. Plants instead rely on the innate immune capacity of each cell and systemic signals that disseminate from infection sites. Successful pathogens use effectors to suppress plant immunity and cause disease. Plants have evolved disease resistance genes encoding immune receptors that perceive specific pathogen effectors to mount effector-triggered immunity. In Arabidopsis, a heteromeric pair of intracellular immune receptors forms a functional recognition complex which senses virulence activities of two structurally unrelated bacterial effectors at the nuclear chromatin. Results suggest that effector targeting of histone modifications and chromatin remodelling interferes with host basal immunity and that this is transduced by the receptor pair to activation of defence pathways. The underlying molecular mechanisms remain unclear. We have found that the two bacterial effectors interact with an overlapping set of chromatin-associated proteins and with certain immune receptor domains. We hypothesize that the effectors converge on the same chromatin machinery for promoting disease and that their actions are intercepted by the immune receptor system which is physically connected to basal immunity signalling components. By using the effectors as molecular probes, this proposal aims to elucidate how the chromatin environment is modulated during infection and how effector perturbations are converted to effective immunity.

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The information about "CHERI" are provided by the European Opendata Portal: CORDIS opendata.

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