Opendata, web and dolomites

CHERI

Chromatin targeting and remodelling by bacterial effectors in plant immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CHERI project word cloud

Explore the words cloud of the CHERI project. It provides you a very rough idea of what is the project "CHERI" about.

arabidopsis    remodelling    pathogen    underlying    disease    cell    forms    activation    mount    sites    structurally    resistance    rely    chromatin    nature    modulated    suggest    interferes    plant    certain    bacteria    disseminate    encoding    modifications    pair    basal    components    lack    immunity    found    suppress    unrelated    intracellular    unlike    elucidate    effectors    converge    converted    recognition    innate    actions    circulating    successful    genes    causing    sustainable    receptor    senses    histone    mammals    systemic    immune    pathogens    host    heteromeric    overlapping    domains    virulence    machinery    hypothesize    perturbations    functional    capacity    nuclear    transduced    receptors    infection    agriculture    mechanisms    signals    plants    defence    proteins    human    unclear    health    physically    signalling    connected    instead    interact    fundamental    effector    challenged    bacterial    intercepted    environment    perceive    fungi    triggered    probes    viruses    molecular   

Project "CHERI" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.mpipz.mpg.de/parker
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

In nature, plants are challenged by disease-causing pathogens such as viruses, bacteria and fungi. Understanding mechanisms of plant disease and disease resistance is of fundamental importance to sustainable agriculture and human health. Unlike mammals, plants lack a circulating immune system. Plants instead rely on the innate immune capacity of each cell and systemic signals that disseminate from infection sites. Successful pathogens use effectors to suppress plant immunity and cause disease. Plants have evolved disease resistance genes encoding immune receptors that perceive specific pathogen effectors to mount effector-triggered immunity. In Arabidopsis, a heteromeric pair of intracellular immune receptors forms a functional recognition complex which senses virulence activities of two structurally unrelated bacterial effectors at the nuclear chromatin. Results suggest that effector targeting of histone modifications and chromatin remodelling interferes with host basal immunity and that this is transduced by the receptor pair to activation of defence pathways. The underlying molecular mechanisms remain unclear. We have found that the two bacterial effectors interact with an overlapping set of chromatin-associated proteins and with certain immune receptor domains. We hypothesize that the effectors converge on the same chromatin machinery for promoting disease and that their actions are intercepted by the immune receptor system which is physically connected to basal immunity signalling components. By using the effectors as molecular probes, this proposal aims to elucidate how the chromatin environment is modulated during infection and how effector perturbations are converted to effective immunity.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHERI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CHERI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

IRF4 Degradation (2019)

Using a novel protein degradation approach to uncover IRF4-regulated genes in plasma cells

Read More  

RealFlex (2019)

Real-time simulator-driver design and manufacturing based on flexible systems

Read More  

GENI (2019)

Gender, emotions and national identities: a new perspective on the abortion debates in Italy (1971-1981).

Read More