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Retargeted Pyocins: A novel tool for combating major food borne pathogens and exploitingphage-host interactions

Total Cost €


EC-Contrib. €






 PYANO project word cloud

Explore the words cloud of the PYANO project. It provides you a very rough idea of what is the project "PYANO" about.

structural    grant    mutational    human    tool    natural    network    teaching    burden    stresses    fused    mediated    predators    supervision    modified    responsible    benefit    treatment    progress    rbp    goals    retargeted    source    myself    antimicrobial    complementary    arsenal    amino    bioinformatics    lack    modulate    pathogen    therapeutics    acids    me    binding    bactericidal    infections    hampers    proteins    microbiology    economic    veterinary    diverse    international    genetic    specificities    skills    interdisciplinary    independent    prevalent    receptors    potent    infecting    background    antimicrobials    complement    phage    researcher    foodborne    identical    exploring    cement    phages    expression    rbps    fellowship    completion    discover    molecular    bacteria    campylobacter    cloning    killing    putative    purification    imposing    urgent    writing    pyocins    hence    sequences    resistance    jejuni    serovars    salmonella    receptor    specificity    similarity   

Project "PYANO" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00


 Project objective

Campylobacter jejuni and Salmonella serovars are the major foodborne pathogen burden of Europe, imposing economic costs and challenging treatment of human infections due to increasing antimicrobial resistance. Hence, the EU commission stresses an urgent need to develop new effective antimicrobials. Exploiting natural predators of bacteria (phages) or phage-derived products may be a source of such novel antimicrobials. But lack of genetic approaches to investigate phage binding mediated by receptor binding proteins (RBPs) hampers progress of phage therapeutics targeting C. jejuni and Salmonella. Thus, goals are to i) discover RBPs of phages infecting C. jejuni and Salmonella serovars using pyocins as a novel advanced tool, and ii) develop novel phage-derived therapeutics with high bactericidal activity targeted to C. jejuni and the most prevalent Salmonella serovars. Putative RBPs will be identified from phage sequences by exploring knowledge of phage receptors and similarity of RBPs among phages binding identical receptors. By creating RBP fused-pyocins, potent killing activity of retargeted pyocins will be used to demonstrate binding specificities of RBPs to C. jejuni and Salmonella. Mutational analysis will identify key amino acids responsible for RBP binding, which also will be modified to modulate the specificity of the retargeted pyocins, developing an arsenal of novel antimicrobials targeting distinct or diverse C. jejuni and Salmonella serovars. On completion of this fellowship, I will complement my veterinary-microbiology background with bioinformatics and molecular skills including cloning, expression, purification, and structural analysis of proteins, allowing me to develop novel interdisciplinary projects exploring phage-derived proteins for human benefit. I will improve my teaching, supervision and complementary skills in project management, grant writing, and establish an international network needed to cement myself as an independent researcher.

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The information about "PYANO" are provided by the European Opendata Portal: CORDIS opendata.

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