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PYANO SIGNED

Retargeted Pyocins: A novel tool for combating major food borne pathogens and exploitingphage-host interactions

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PYANO project word cloud

Explore the words cloud of the PYANO project. It provides you a very rough idea of what is the project "PYANO" about.

jejuni    diverse    burden    serovars    phages    me    fused    therapeutics    modulate    cement    potent    amino    expression    stresses    salmonella    rbps    molecular    completion    acids    tool    modified    specificity    infections    antimicrobial    imposing    progress    similarity    bacteria    mediated    putative    complementary    network    background    exploring    lack    binding    receptor    cloning    researcher    treatment    discover    responsible    economic    microbiology    structural    natural    proteins    pyocins    receptors    arsenal    hampers    retargeted    prevalent    grant    interdisciplinary    mutational    identical    antimicrobials    resistance    campylobacter    international    sequences    bactericidal    urgent    killing    independent    human    goals    purification    pathogen    predators    genetic    phage    myself    complement    bioinformatics    supervision    specificities    rbp    source    skills    teaching    foodborne    hence    benefit    fellowship    veterinary    infecting    writing   

Project "PYANO" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://ivh.ku.dk/english/research/food_safety_and_zoonoses/phages/pyano/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

Campylobacter jejuni and Salmonella serovars are the major foodborne pathogen burden of Europe, imposing economic costs and challenging treatment of human infections due to increasing antimicrobial resistance. Hence, the EU commission stresses an urgent need to develop new effective antimicrobials. Exploiting natural predators of bacteria (phages) or phage-derived products may be a source of such novel antimicrobials. But lack of genetic approaches to investigate phage binding mediated by receptor binding proteins (RBPs) hampers progress of phage therapeutics targeting C. jejuni and Salmonella. Thus, goals are to i) discover RBPs of phages infecting C. jejuni and Salmonella serovars using pyocins as a novel advanced tool, and ii) develop novel phage-derived therapeutics with high bactericidal activity targeted to C. jejuni and the most prevalent Salmonella serovars. Putative RBPs will be identified from phage sequences by exploring knowledge of phage receptors and similarity of RBPs among phages binding identical receptors. By creating RBP fused-pyocins, potent killing activity of retargeted pyocins will be used to demonstrate binding specificities of RBPs to C. jejuni and Salmonella. Mutational analysis will identify key amino acids responsible for RBP binding, which also will be modified to modulate the specificity of the retargeted pyocins, developing an arsenal of novel antimicrobials targeting distinct or diverse C. jejuni and Salmonella serovars. On completion of this fellowship, I will complement my veterinary-microbiology background with bioinformatics and molecular skills including cloning, expression, purification, and structural analysis of proteins, allowing me to develop novel interdisciplinary projects exploring phage-derived proteins for human benefit. I will improve my teaching, supervision and complementary skills in project management, grant writing, and establish an international network needed to cement myself as an independent researcher.

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The information about "PYANO" are provided by the European Opendata Portal: CORDIS opendata.

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