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Exosomes

Regulated secretion and role of urinary nanovesicles

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Exosomes project word cloud

Explore the words cloud of the Exosomes project. It provides you a very rough idea of what is the project "Exosomes" about.

ideas    rates    membrane    biological    immunology    released    presentation    cargo    fellowship    secretion    roles    independently    laboratory    collaborations    small    basis    transdisciplinary    freedom    multiple    host    release    profiling    exosome    urine    me    give    lab    immunity    patients    goals    career    provides    materials    constituents    antigen    quantitative    tumor    collecting    mechanisms    transfer    qualitative    run    scientific    contributes    extensive    cell    samples    proteomics    proteins    microbiological    prospects    bioinformatics    techniques    regulated    gain    combine    bacteria    underlying    genetic    pathophysiological    portfolio    protein    vesicles    disciplines    origin    renal    unclear    combined    urinary    inhibit    implications    int    types    capacity    incl    examine    nanovesicles    communications    exosomes    neurobiology    normal    molecular    skills    intercellular    contain    proteomic    biology    bound    innate    secreted    pathogen    variety    extracellular    stem   

Project "Exosomes" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://interpret.au.dk/other-funded-research-projects/regulated-secretion-and-role-of-urinary-nanovesicles/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 200˙194.00

Map

 Project objective

Extracellular nanovesicles called “exosomes” are small membrane-bound vesicles that are secreted by a variety of cell types. Exosomes contain various molecular constituents of their cell of origin, incl. proteins and genetic materials. The exosome release pathway contributes towards protein secretion, antigen presentation and pathogen transfer and roles of exosomes in intercellular communications and transfer of materials have been studied in immunology, neurobiology, stem cell and tumor biology. Exosomes are also released into the urine, although their role in urine is unclear and provides the basis of this fellowship. To gain novel information about urinary exosomes, a transdisciplinary approach is required. I will use my current knowledge of qualitative and quantitative proteomics combined with extensive bioinformatics to study urinary and renal exosomes and their ‘cargo’ secreted under normal and pathophysiological conditions. I will combine this information with new ideas and techniques I will learn in my host laboratory to examine rates of exosome secretion and to assess whether exosomes have the capacity to inhibit the growth of bacteria. Methodologies in this fellowship include techniques which I have extensive experience of e.g. large scale proteomic profiling, and novel techniques that I will learn in the host lab to enhance my research portfolio and future career prospects, including cell biological and microbiological techniques and experience in collecting/using samples from patients. The scientific goals of the project are to investigate the underlying mechanisms for regulated exosome secretion and the role of exosomes in innate immunity. As exosomes are secreted from multiple cell types, this study will have major implications for a variety of biology disciplines. The fellowship will develop my career by providing new novel laboratory skills, it will give me greater freedom to independently run a research project and increase my int collaborations.

 Publications

year authors and title journal last update
List of publications.
2019 Qi Wu, Takwa S. Aroankins, Lei Cheng, Robert A. Fenton
SUMOylation Landscape of Renal Cortical Collecting Duct Cells
published pages: 3640-3648, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.9b00306
Journal of Proteome Research 18/10 2020-01-20
2018 Robert A. Fenton
Proteomic approaches in kidney disease biomarker discovery
published pages: F1817-F1821, ISSN: 1931-857X, DOI: 10.1152/ajprenal.00421.2018
American Journal of Physiology-Renal Physiology 315/6 2020-01-20
2019 Lei Cheng, Søren Brandt Poulsen, Qi Wu, Cristina Esteva-Font, Emma T. B. Olesen, Li Peng, Björn Olde, L. M. Fredrik Leeb-Lundberg, Trairak Pisitkun, Timo Rieg, Henrik Dimke, Robert A. Fenton
Rapid Aldosterone-Mediated Signaling in the DCT Increases Activity of the Thiazide-Sensitive NaCl Cotransporter
published pages: 1454-1470, ISSN: 1046-6673, DOI: 10.1681/asn.2018101025
Journal of the American Society of Nephrology 30/8 2020-01-20
2018 Qi Wu, Hanne B. Moeller, Donté A. Stevens, Rebekah Sanchez-Hodge, Gabrielle Childers, Marleen L.A. Kortenoeven, Lei Cheng, Lena L. Rosenbaek, Carrie Rubel, Cam Patterson, Trairak Pisitkun, Jonathan C. Schisler, Robert A. Fenton
CHIP Regulates Aquaporin-2 Quality Control and Body Water Homeostasis
published pages: ASN.2017050526, ISSN: 1046-6673, DOI: 10.1681/ASN.2017050526
Journal of the American Society of Nephrology 2020-01-20

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The information about "EXOSOMES" are provided by the European Opendata Portal: CORDIS opendata.

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