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DASCE TERMINATED

Dissecting specific amygdala-striatal circuits for exploration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 DASCE project word cloud

Explore the words cloud of the DASCE project. It provides you a very rough idea of what is the project "DASCE" about.

emotional    progression    area    evolution    animal    behavior    hypothesized    brain    mice    experiences    moving    caused    projections    employ    combination    ensembles    encoding    mechanism    exploratory    neuronal    starting    gain    optogenetic    dictated    behavioral    environment    variety    medial    circuitries    causally    dorso    multiple    imaging    compartment    uncover    depression    unfamiliar    striatal    collaborative    directed    amygdala    explore    striatum    classes    strategies    cell    beneficial    multidisciplinary    innate    techniques    survival    neurons    planning    overcome    behaviors    elusive    surroundings    exploring    projecting    disorders    projection    connected    fine    nature    types    specificity    actions    cure    exact    emotions    implication    intricate    animals    learned    dependent    post    circumstances    familiar    mammals    computational    variability    anxiety    unpredictable    psychiatric    technique    reveal    gained    functionally    calcium    unknown   

Project "DASCE" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 148˙635.00

Map

 Project objective

Survival and adaptation are dependent on an animal's ability to gain novel information in unfamiliar surroundings. Similar to other animal classes, mammals must use a variety of innate and learned exploratory strategies that are dictated by unpredictable or unknown circumstances. As the combination of emotional processes and planning of complex actions are essential for the development of such strategies, it can be hypothesized that strongly connected brain areas involved in emotions (the amygdala) and goal-directed behaviors (the dorso-medial striatum) have an implication on exploratory behavior. The intricate neuronal nature and brain area specificity in the controlling of such strategies, however, remain elusive. In order to functionally uncover the role of specific amygdala-striatal long-range projections in freely-exploring mice, our collaborative study will adopt a multidisciplinary approach by a) developing a multiple-compartment behavioral task to study the exact evolution of exploratory strategies in a novel environment starting from a familiar one, b) examining the neuronal encoding of amygdala-striatal projecting neurons during exploratory progression using a novel calcium imaging technique in freely-moving animals, and c) causally relating the role of pre- and post- neuronal ensembles to exploratory strategies applying a projection-specific optogenetic approach. Furthermore, the proposed project will employ state-of -the-art techniques to reveal the fine computational mechanism used by animals to explore their surroundings and to determine the neuronal encoding specific to brain-, cell- and projection-types. Our research will be beneficial not only for understanding the role of defined circuitries in behavioral variability caused by unpredictable circumstances and the ability to overcome these through the knowledge gained from past experiences, but also for the finding of a cure for complex psychiatric disorders including anxiety and depression.

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The information about "DASCE" are provided by the European Opendata Portal: CORDIS opendata.

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