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DASCE TERMINATED

Dissecting specific amygdala-striatal circuits for exploration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DASCE project word cloud

Explore the words cloud of the DASCE project. It provides you a very rough idea of what is the project "DASCE" about.

survival    connected    behaviors    amygdala    mammals    unfamiliar    behavior    animal    employ    ensembles    techniques    learned    surroundings    circumstances    medial    striatum    cell    computational    unpredictable    dorso    overcome    mechanism    exploring    functionally    depression    exact    intricate    actions    area    optogenetic    technique    reveal    striatal    combination    specificity    emotional    causally    circuitries    explore    innate    variety    calcium    implication    evolution    projecting    progression    directed    unknown    psychiatric    environment    classes    animals    familiar    moving    projections    elusive    starting    caused    dependent    beneficial    collaborative    strategies    brain    neuronal    fine    multidisciplinary    nature    encoding    mice    uncover    hypothesized    experiences    planning    projection    cure    behavioral    multiple    anxiety    gain    neurons    disorders    gained    post    variability    dictated    emotions    exploratory    imaging    compartment    types   

Project "DASCE" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 148˙635.00

Map

 Project objective

Survival and adaptation are dependent on an animal's ability to gain novel information in unfamiliar surroundings. Similar to other animal classes, mammals must use a variety of innate and learned exploratory strategies that are dictated by unpredictable or unknown circumstances. As the combination of emotional processes and planning of complex actions are essential for the development of such strategies, it can be hypothesized that strongly connected brain areas involved in emotions (the amygdala) and goal-directed behaviors (the dorso-medial striatum) have an implication on exploratory behavior. The intricate neuronal nature and brain area specificity in the controlling of such strategies, however, remain elusive. In order to functionally uncover the role of specific amygdala-striatal long-range projections in freely-exploring mice, our collaborative study will adopt a multidisciplinary approach by a) developing a multiple-compartment behavioral task to study the exact evolution of exploratory strategies in a novel environment starting from a familiar one, b) examining the neuronal encoding of amygdala-striatal projecting neurons during exploratory progression using a novel calcium imaging technique in freely-moving animals, and c) causally relating the role of pre- and post- neuronal ensembles to exploratory strategies applying a projection-specific optogenetic approach. Furthermore, the proposed project will employ state-of -the-art techniques to reveal the fine computational mechanism used by animals to explore their surroundings and to determine the neuronal encoding specific to brain-, cell- and projection-types. Our research will be beneficial not only for understanding the role of defined circuitries in behavioral variability caused by unpredictable circumstances and the ability to overcome these through the knowledge gained from past experiences, but also for the finding of a cure for complex psychiatric disorders including anxiety and depression.

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The information about "DASCE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2021-09-20 7:14:39) correctly updated