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DASCE TERMINATED

Dissecting specific amygdala-striatal circuits for exploration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 DASCE project word cloud

Explore the words cloud of the DASCE project. It provides you a very rough idea of what is the project "DASCE" about.

actions    techniques    mechanism    hypothesized    caused    classes    uncover    variety    computational    multidisciplinary    causally    animals    gain    disorders    emotions    dictated    dependent    brain    reveal    projections    familiar    planning    encoding    moving    exploring    psychiatric    experiences    mammals    projection    cure    progression    imaging    behaviors    circumstances    animal    types    behavior    optogenetic    evolution    variability    intricate    ensembles    fine    unknown    specificity    area    surroundings    survival    dorso    explore    employ    multiple    neurons    nature    striatal    beneficial    collaborative    unpredictable    mice    overcome    exploratory    unfamiliar    environment    learned    circuitries    anxiety    functionally    depression    amygdala    implication    cell    exact    technique    projecting    behavioral    gained    neuronal    directed    strategies    calcium    striatum    innate    medial    starting    combination    post    connected    compartment    emotional    elusive   

Project "DASCE" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 148˙635.00

Map

 Project objective

Survival and adaptation are dependent on an animal's ability to gain novel information in unfamiliar surroundings. Similar to other animal classes, mammals must use a variety of innate and learned exploratory strategies that are dictated by unpredictable or unknown circumstances. As the combination of emotional processes and planning of complex actions are essential for the development of such strategies, it can be hypothesized that strongly connected brain areas involved in emotions (the amygdala) and goal-directed behaviors (the dorso-medial striatum) have an implication on exploratory behavior. The intricate neuronal nature and brain area specificity in the controlling of such strategies, however, remain elusive. In order to functionally uncover the role of specific amygdala-striatal long-range projections in freely-exploring mice, our collaborative study will adopt a multidisciplinary approach by a) developing a multiple-compartment behavioral task to study the exact evolution of exploratory strategies in a novel environment starting from a familiar one, b) examining the neuronal encoding of amygdala-striatal projecting neurons during exploratory progression using a novel calcium imaging technique in freely-moving animals, and c) causally relating the role of pre- and post- neuronal ensembles to exploratory strategies applying a projection-specific optogenetic approach. Furthermore, the proposed project will employ state-of -the-art techniques to reveal the fine computational mechanism used by animals to explore their surroundings and to determine the neuronal encoding specific to brain-, cell- and projection-types. Our research will be beneficial not only for understanding the role of defined circuitries in behavioral variability caused by unpredictable circumstances and the ability to overcome these through the knowledge gained from past experiences, but also for the finding of a cure for complex psychiatric disorders including anxiety and depression.

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The information about "DASCE" are provided by the European Opendata Portal: CORDIS opendata.

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