Explore the words cloud of the ROQ-WACh project. It provides you a very rough idea of what is the project "ROQ-WACh" about.
The following table provides information about the project.
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
|Coordinator Country||Spain [ES]|
|Total cost||158˙121 €|
|EC max contribution||158˙121 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-03-01 to 2018-02-28|
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|1||FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE||ES (L'HOSPITALET DE LLOBREGAT)||coordinator||158˙121.00|
Precise regulation of gene expression is achieved through the coordinated action of genomic cis-regulatory modules (CRMs). The identification of CRMs has long been a goal of functional genomics as CRM dysregulation can have devastating consequences for health and development such as autism. For example, mutations in the MeCP2 gene, which encodes protein that binds methylated DNA and regulates gene expression in neurons, results an Autism Spectrum Disorder termed Rett Syndrome. While thought to modulate CRM activity as a repressor, MeCP2’s function remains ambiguous and would benefit from a functional genomics characterization. To identify CRMs I recently developed a novel approach called FIREWACh. Here, I propose to utilize FIREWACh first to identify active CRMs within a homogenous population of neurons, identifying genomic loci of CRMs whose function may be compromised by MeCP2 mutations. I will adapt FIREWACh to allow the quantification of CRM output in a new method I propose to call ROQ-WACh (regulatory output quantification within accessible chromatin) by addition of barcodes to reporter mRNAs. This will allow high-throughput readout of CRM activity globally in vivo and will be broadly applicable to many biological fields. Lastly, I aim to combine the above approaches to quantify the changes in CRM output in response to pathological mutations in MeCP2. This Marie Sklodowska-Curie Action will allow me (the Experienced Researcher, Matthew Murtha) mobility to Spain to join the laboratory of Dr. Manel Esteller (Host Supervisor), renowned epigeneticist and expert in DNA-methylation biology to perform the research. Together the approaches and data generated by this MSCA action will provide key insights into the relationship between methylated DNA, precise control of gene expression, and high-order phenotypes such as cognitive behaviors.
|year||authors and title||journal||last update|
Andrea Izquierdo-Bouldstridge, Alberto Bustillos, Carles Bonet-Costa, Patricia Aribau-MiralbÃ©s, Daniel GarcÃa-Gomis, Marc Dabad, Anna Esteve-Codina, Laura Pascual-Reguant, Sandra PeirÃ³, Manel Esteller, Matthew Murtha, LluÃs MillÃ¡n-AriÃ±o, Albert Jordan
Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats
published pages: 11622-11642, ISSN: 0305-1048, DOI: 10.1093/nar/gkx746
|Nucleic Acids Research 45/20||2019-06-13|
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