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SPARk SIGNED

Adding Pieces to the Puzzle of Sexual Differentiation In P. falciparum: A Systematic Analysis of RNA Processing

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 SPARk project word cloud

Explore the words cloud of the SPARk project. It provides you a very rough idea of what is the project "SPARk" about.

concentrated    mortality    rna    rnas    health    severe    malaria    mosquito    falciparum    specialized    stage    reintegrate    gametocytogenesis    public    vector    recombinantly    sexual    acquisition    gametocytes    gap    devastating    times    characterisation    phases    expression    mechanism    modulate    orchestrate    genetics    causes    form    genetic    gene    add    transgenic    harvard    diseases    school    community    time    regulation    splicing    post    developmental    disease    heaviest    switching    additionally    host    professional    transcriptional    gametocyte    elucidate    plasmodium    endemic    scientific    differentiation    binding    poor    cellular    living    upregulated    employs    subset    cycle    transformation    modern    environments    stages    preparatory    proteins    young    life    treat    signals    children    parasites    combination    skills    ing    genes    structured    countries    onset    biology    switches    resource    transmission    me    phenotype    generate    underlying    completion    astonishing   

Project "SPARk" data sheet

The following table provides information about the project.

Coordinator		 JUSTUS-LIEBIG-UNIVERSITAET GIESSEN 

Organization address
address: LUDWIGSTRASSE 23
city: GIESSEN
postcode: 35390
website: www.uni-giessen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://www.uni-giessen.de/fbz/fb09/institute/ernaehrungswissenschaft/prof/becker/druid/research/projekte/nukleaere/a5
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JUSTUS-LIEBIG-UNIVERSITAET GIESSEN DE (GIESSEN) coordinator 171˙460.00

Map

 Project objective

Malaria remains one of the most devastating diseases in modern times, with the heaviest mortality concentrated in young children living in resource-poor environments. Plasmodium falciparum causes the most severe form of malaria. The parasites have a complex life cycle, switching between a host and a mosquito vector. Transformation of a subset of parasites into specialized stages capable of sexual development – the gametocytes – is one of the most astonishing, yet not well understood, Plasmodium life cycle phases. As preparatory work for this proposal during my time at Harvard School of Public Health, I identified pathways specifically upregulated at the onset of sexual differentiation, an important gap in our knowledge of gametocytogenesis. Among these, four genes involved in different aspects of post-transcriptional gene regulation were highly upregulated. Studying this aspect of gametocyte biology can add to our understanding of how Plasmodium parasites orchestrate complex genetics switches and modulate the cellular response to developmental signals. The aim of this proposal is to provide insight how these RNA-binding proteins contribute to sexual stage-specific gene expression. This project employs genetic approaches to investigate the role of these proteins during sexual development of P. falciparum. For that I will generate transgenic parasites and analyse the resulting phenotype in detail. Additionally, this study aims at characterisation the splicing activity of recombinantly produced proteins and to determine target RNAs in order to elucidate the underlying mechanism of RNA processing control. This proposal can contribute to improved health conditions in malaria-endemic countries through a better understanding of malaria transmission and new approaches to treat the disease. Completion of the scientific project in combination with the proposed structured acquisition of professional skills will enable me to reintegrate into the European research community.

 Publications

year authors and title journal last update
List of publications.
2018 Anna Katharina Schuh, Mahsa Rahbari, Franziska Mohring, Stanislaw J. Gabryszewski, Kim C. Heimsch, Stine Weder, Kathrin Buchholz, Stefan Rahlfs, David A. Fidock, Katja Becker
Stable integration and comparison of hGrx1-roGFP2 and sfroGFP2 redox probes in the malaria parasite Plasmodium falciparum
published pages: , ISSN: 0891-5849, DOI: 		Free Radical Biologie & Medicine 2019-06-13

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