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SPARk SIGNED

Adding Pieces to the Puzzle of Sexual Differentiation In P. falciparum: A Systematic Analysis of RNA Processing

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 SPARk project word cloud

Explore the words cloud of the SPARk project. It provides you a very rough idea of what is the project "SPARk" about.

splicing    underlying    mechanism    form    structured    upregulated    gene    biology    mortality    harvard    gametocytes    proteins    gap    onset    time    me    transcriptional    combination    times    endemic    young    falciparum    differentiation    genetic    treat    stage    countries    life    vector    add    modulate    sexual    host    signals    binding    public    poor    reintegrate    severe    living    gametocyte    recombinantly    cycle    developmental    switches    devastating    post    orchestrate    acquisition    concentrated    resource    rna    preparatory    professional    skills    subset    transformation    generate    modern    transmission    environments    children    elucidate    mosquito    genes    phenotype    regulation    rnas    stages    transgenic    plasmodium    additionally    diseases    community    causes    heaviest    malaria    specialized    expression    phases    scientific    genetics    ing    switching    disease    parasites    school    cellular    characterisation    employs    completion    gametocytogenesis    health    astonishing   

Project "SPARk" data sheet

The following table provides information about the project.

Coordinator		 JUSTUS-LIEBIG-UNIVERSITAET GIESSEN 

Organization address
address: LUDWIGSTRASSE 23
city: GIESSEN
postcode: 35390
website: www.uni-giessen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website http://www.uni-giessen.de/fbz/fb09/institute/ernaehrungswissenschaft/prof/becker/druid/research/projekte/nukleaere/a5
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2018-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JUSTUS-LIEBIG-UNIVERSITAET GIESSEN DE (GIESSEN) coordinator 171˙460.00

Map

 Project objective

Malaria remains one of the most devastating diseases in modern times, with the heaviest mortality concentrated in young children living in resource-poor environments. Plasmodium falciparum causes the most severe form of malaria. The parasites have a complex life cycle, switching between a host and a mosquito vector. Transformation of a subset of parasites into specialized stages capable of sexual development – the gametocytes – is one of the most astonishing, yet not well understood, Plasmodium life cycle phases. As preparatory work for this proposal during my time at Harvard School of Public Health, I identified pathways specifically upregulated at the onset of sexual differentiation, an important gap in our knowledge of gametocytogenesis. Among these, four genes involved in different aspects of post-transcriptional gene regulation were highly upregulated. Studying this aspect of gametocyte biology can add to our understanding of how Plasmodium parasites orchestrate complex genetics switches and modulate the cellular response to developmental signals. The aim of this proposal is to provide insight how these RNA-binding proteins contribute to sexual stage-specific gene expression. This project employs genetic approaches to investigate the role of these proteins during sexual development of P. falciparum. For that I will generate transgenic parasites and analyse the resulting phenotype in detail. Additionally, this study aims at characterisation the splicing activity of recombinantly produced proteins and to determine target RNAs in order to elucidate the underlying mechanism of RNA processing control. This proposal can contribute to improved health conditions in malaria-endemic countries through a better understanding of malaria transmission and new approaches to treat the disease. Completion of the scientific project in combination with the proposed structured acquisition of professional skills will enable me to reintegrate into the European research community.

 Publications

year authors and title journal last update
List of publications.
2018 Anna Katharina Schuh, Mahsa Rahbari, Franziska Mohring, Stanislaw J. Gabryszewski, Kim C. Heimsch, Stine Weder, Kathrin Buchholz, Stefan Rahlfs, David A. Fidock, Katja Becker
Stable integration and comparison of hGrx1-roGFP2 and sfroGFP2 redox probes in the malaria parasite Plasmodium falciparum
published pages: , ISSN: 0891-5849, DOI: 		Free Radical Biologie & Medicine 2019-06-13

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