EMBEK1

Development and analysis of polymer based multi-functional bactericidal materials

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Udo
Cognome: Schreiner
Email: send email
Telefono: +49 6131 379 423
Fax: +49 6131 379 155

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.mpip-mainz.mpg.de/eu-projekte/embek1/
 Totale costo 3˙953˙777 €
 EC contributo 2˙914˙466 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2007-SMALL-1
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-08-01   -   2011-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Udo
Cognome: Schreiner
Email: send email
Telefono: +49 6131 379 423
Fax: +49 6131 379 155

DE (MUENCHEN) coordinator 0.00
2    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Ms.
Nome: Mar
Cognome: Garcia-Ferrer
Email: send email
Telefono: +34 915854 984
Fax: +34 915855 360

ES (MADRID) participant 0.00
3    EIDGENOESSISCHE MATERIALPRUEFUNGS- UND FORSCHUNGSANSTALT

 Organization address address: Ueberlandstrasse 129
city: DUEBENDORF
postcode: 8600

contact info
Titolo: Dr.
Nome: Dirk
Cognome: Hegemann
Email: send email
Telefono: +41 71 274 7268
Fax: 41712747569

CH (DUEBENDORF) participant 0.00
4    JOHANNES GUTENBERG UNIVERSITAET MAINZ

 Organization address address: SAARSTRASSE 21
city: MAINZ
postcode: 55099

contact info
Titolo: Ms.
Nome: Petra
Cognome: Seebauer-Enste
Email: send email
Telefono: +49 6131 17 3922
Fax: +49 6131 17 5520

DE (MAINZ) participant 0.00
5    KLINIKUM DER UNIVERSITAET ZU KOELN

 Organization address address: Kerpener Strasse 62
city: KOELN
postcode: 50937

contact info
Titolo: Ms.
Nome: Jutta
Cognome: Landvogt
Email: send email
Telefono: +49 221 478 5204
Fax: +49 221 478 5543

DE (KOELN) participant 0.00
6    NPL MANAGEMENT LIMITED

 Organization address address: SERCO HOUSE 16 BARTLEY WOOD - BUSINESS PARK BARTLEY WAY 16
city: HOOK - HAMPSHIRE
postcode: RG27 9UY

contact info
Titolo: Dr.
Nome: Neil
Cognome: Harrison
Email: send email
Telefono: -15362
Fax: -15372

UK (HOOK - HAMPSHIRE) participant 0.00
7    ROCHE DIAGNOSTICS GMBH

 Organization address address: Sandhofer Strasse 116
city: MANNHEIM
postcode: 68305

contact info
Titolo: Ms.
Nome: Christa
Cognome: Hübner-Parajsz
Email: send email
Telefono: +49 88 5660 3343
Fax: +49 88 5660 3011

DE (MANNHEIM) participant 0.00
8    SEFAR AG

 Organization address address: HINTERBISSAUSTRASSE 12
city: HEIDEN
postcode: 9410

contact info
Titolo: Dr.
Nome: Peter
Cognome: Chabrecek
Email: send email
Telefono: +41 71 886 3454
Fax: +41 71 886 3504

CH (HEIDEN) participant 0.00
9    THE UNIVERSITY OF EXETER

 Organization address address: Northcote House, The Queen's Drive
city: EXETER
postcode: EX4 4QJ

contact info
Titolo: Dr.
Nome: Enda
Cognome: Clarke
Email: send email
Telefono: +44 13 9226 3744
Fax: +44 13 9226 3686

UK (EXETER) participant 0.00
10    UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ

 Organization address address: Langenbeckstrasse 1
city: Mainz
postcode: 55131

contact info
Titolo: Dr.
Nome: Silvia
Cognome: Tschauder
Email: send email
Telefono: 496131000000
Fax: 496131000000

DE (Mainz) participant 0.00
11    UNIVERSITY OF BATH

 Organization address address: CLAVERTON DOWN
city: BATH
postcode: BA2 7AY

contact info
Titolo: Mr.
Nome: Peter
Cognome: Hompstead
Email: send email
Telefono: 441225000000
Fax: 441225000000

UK (BATH) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

health    films    attach    iterative    hospital    techniques    resistance    adherence    drugs    care    materials    release    infection    silver    antimicrobial    outcomes    attachment    mechanisms    prevented    embek    solid    metal    infections    patients    forming    antibiotics    model    problem    copper    led    scientists    catheters    zinc    industry    bio    bacterial    biological    treatments    surfaces    surgical    us    bacteria    coatings    create    implants   

 Obiettivo del progetto (Objective)

'90% of bacteria are found attached to solid surfaces forming structures (bio-films), that are inaccessible to drugs and antibiotics. These bio-films represent a major problem in European society in both industry and health care. Currently, however, we understand little about how these bio-films form and, more importantly, how they can be prevented. This lack of understanding means that patients often suffer ‘unnecessary’ and painful infections following the formation of such films on surgical implants and catheters. With the growing problem of MRSA and C. difficile in hospitals, and the cost of policing and hygiene measures, an understanding of how to prevent bacterial persistence in the hospital environment is critical to the sustainability of European healthcare. A multi-disciplinary group of European experts have the common aim to understand exactly how bacteria attach to, and persist on both biological and inert surfaces. We will use a range of biological and physio-chemical techniques to study several fundamental aspects of bacterial attachment. We will employ new molecular microbiology techniques to understand the genetic components governing the interaction of a bacterial biotic cell surface with the novel antimicrobial surfaces we create. Second, we will be using new nano-scale material science and physical chemistry techniques to create and understand these antimicrobial surfaces. This duel systems approach will allow us to theoretically model the processes of bacterial attachment and survival, which in turn will allow us to improve these surfaces in an iterative approach. We will generate intellectual property around the coatings and treatments used to derive the surfaces and develop these in collaboration with industry. The solutions will be designed specifically for the industrial partners participating in the project but can, with a minimum effort be adapted for applications in other areas through the iterative steps within the WPs.'

Introduzione (Teaser)

Patients with surgical implants or catheters are subject to bacterial infection at the site of insertion. EU-funded scientists are developing novel antimicrobial materials to stop bacterial adherence and growth.

Descrizione progetto (Article)

Most bacteria attach to solid surfaces by forming a film that makes them impervious to drugs and antibiotics. Despite numerous studies on bacteria over the years, knowledge about the formation of bio films and their prevention is still limited. Scientists initiated the EU-funded project 'Development and analysis of polymer based multi-functional bactericidal materials' (EMBEK1) to fill this knowledge gap and use it to develop antimicrobial materials for sustainable European health care.

Materials development has led to several novel combinations, including metal ion-release systems with controllable release properties. Effectiveness of metal ions (silver, zinc or copper) in treating certain bacteria, as well as the appropriate doses for antibacterial activity without toxicity were revealed.

Scientists have also used biocompatible vesicles loaded with antimicrobial agents to release drugs or viruses (bacteriophages) that selectively infect pathogenic bacteria on biological activation. Project-generated data could play an important role in the development of phage-containing wound bandages and creams.

Selected coatings are now being tested on hospital textiles. Some coatings successfully prevented the adherence and growth of bacteria while promoting the adherence and growth of healthy tissue to support the biointegration of an implant. Successful outcomes have led to a patent application.

Finally, using sophisticated genetics and proteomics, scientists are studying an insect model of infection and the effects of silver, zinc and copper-release systems to understand mechanisms of bacterial resistance. Particularly exciting was the fact that two common bacteria during the 18 months of study showed no signs of developed resistance to zinc.

EMBEK1 has already made significant progress in understanding the mechanisms of bacterial growth on surfaces and the development of antimicrobial treatments. Project outcomes are expected to have major impact on the reduction of hospital infections, improving the quality of patient care and decreasing its cost.

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