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EBOPATH

Evaluation of species-specific ebolavirus pathophysiology in xenochimeric mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "EBOPATH" data sheet

The following table provides information about the project.

Coordinator
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN 

Organization address
address: BERNHARD NOCHT STRASSE 74
city: HAMBURG
postcode: 20359
website: www.bni.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.bnitm.de
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN DE (HAMBURG) coordinator 71˙442.00
2    HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE DE (HAMBURG) participant 100˙018.00

Map

 Project objective

Ebolaviruses comprise five virus species of which at least three are highly pathogenic for humans. Other mammalian species such as non-human primates, forest antelopes and pigs are susceptible to ebolavirus infection with different degree of severity. However, bats and laboratory mice are entirely resistant to ebolaviruses. Why do ebolaviruses cause severe disease in some species but not others? This question, which is paramount to understand ebolavirus pathogenesis is the central question of our proposal. To address it, we will build on technology developed by the host laboratory to develop xenochimeric mice, that is, severely immunodeficient mice whose hematopoietic system has been replaced with another from a donor species (e. g. bats, monkeys or humans). This novel in vivo system will allow us to investigate the kinetics of ebolavirus infection across species and to dissect the mechanisms responsible for pathogenicity.

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The information about "EBOPATH" are provided by the European Opendata Portal: CORDIS opendata.

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