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GallBiome

Characterization of the Human Gallbladder Microbiome

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GallBiome project word cloud

Explore the words cloud of the GallBiome project. It provides you a very rough idea of what is the project "GallBiome" about.

ultimately    metabolomics    risk    harbors    recovery    characterization    intake    form    assemblage    intestinal    communities    uncover    cohort    gastrointestinal    regulate    lacking    host    decade    metagenomics    composition    expand    gut    diagnostics    informing    incidence    physiology    disease    benefits    biomarkers    food    rrna    gallbladder    energy    molecular    emergency    basis    removed    confer    biopsies    surgically    establishing    duodenum    bacterial    inhabitants    healthy    samples    medical    entering    profiles    removal    implications    performed    community    million    gallbladders    immunological    lower    human    microbiomes    cholelithiasis    population    biological    microbiota    received    view    downstream    microorganisms    neurological    investigations    therapeutics    16s    scientists    stool    cultivation    health    microbiome    techniques    surgeries    relationships    begun    gallbiome    unknown    elucidated    bile    last    mucosa    microbial    undergoing    content    core    site    period    adherent    collected    metabolic    cholecystectomies    once    tract    fat   

Project "GallBiome" data sheet

The following table provides information about the project.

Coordinator
TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY 

Organization address
address: Oak Park
city: Carlow
postcode: R93
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://apc.ucc.ie/profile-dr-crystal-johnson/
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY IE (Carlow) coordinator 187˙866.00

Map

 Project objective

The human gastrointestinal tract harbors a complex community of microorganisms that confer metabolic, immunological and neurological benefits to the host. This assemblage is known as the Gut Microbiome and has received increased attention over the last decade. Scientists have begun to uncover the importance of these bacterial inhabitants and expand investigations to consider how site-specific microbiomes affect host physiology. While more than one million cholecystectomies (gallbladder removal surgeries) are performed throughout Europe each year, the bacterial communities associated with the human gallbladder and its disease states remain unknown. Studies are lacking that characterize the effects of cholecystectomies on the gut microbiome. Without the ability to regulate bile entering the duodenum during food intake, it is expected that gallbladder removal will lead to downstream changes in the intestinal population. Here, the microbial composition of human bile, gallbladder mucosa, and biopsies of surgically removed healthy gallbladders (adherent and non-adherent microbiota) will be investigated using 16S rRNA metagenomics. The profiles will be compared to samples of a second cohort undergoing emergency cholecystectomies, in order to identify possible biomarkers for gallbladder disease. Once the gallbladder microbiome has been elucidated, the impact of its removal on the gut microbiome will be assessed. Using molecular and cultivation based techniques, on stool samples (collected during the recovery period) and analyzed for community composition, metabolomics, bile, fat and energy content. GallBiome will form the basis for establishing relationships between gallbladder microbiota, gut microbiota, and human health with a view to informing future development of diagnostics and therapeutics. Ultimately, characterization of the core gallbladder microbiome has important biological and medical implications with potential to lower the risk and incidence of cholelithiasis.

 Publications

year authors and title journal last update
List of publications.
2018 Crystal Johnson, Criostoir O’Suilleabhain, Paul Ross, Catherine Stanton
The Human GallBiome, At The Interface of Hepatic Health and Disease
published pages: , ISSN: , DOI:
International Symposium of the International Scientific Association of Probiotics and Prebiotics 2019-06-13

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