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GallBiome

Characterization of the Human Gallbladder Microbiome

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GallBiome project word cloud

Explore the words cloud of the GallBiome project. It provides you a very rough idea of what is the project "GallBiome" about.

neurological    bile    communities    once    biopsies    characterization    view    human    removal    decade    basis    received    uncover    physiology    entering    emergency    biomarkers    surgically    population    risk    inhabitants    samples    gallbladder    fat    duodenum    metagenomics    intestinal    metabolic    ultimately    microbiota    community    energy    intake    metabolomics    therapeutics    performed    incidence    regulate    host    profiles    adherent    benefits    healthy    gastrointestinal    investigations    cohort    scientists    informing    lacking    mucosa    unknown    elucidated    implications    molecular    gut    immunological    gallbiome    rrna    million    form    gallbladders    microbiome    stool    begun    undergoing    cholecystectomies    composition    last    tract    health    techniques    cultivation    relationships    content    diagnostics    confer    surgeries    period    16s    disease    microbiomes    microbial    lower    expand    site    food    harbors    medical    microorganisms    bacterial    establishing    biological    removed    assemblage    core    downstream    cholelithiasis    recovery    collected   

Project "GallBiome" data sheet

The following table provides information about the project.

Coordinator
TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY 

Organization address
address: Oak Park
city: Carlow
postcode: R93
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://apc.ucc.ie/profile-dr-crystal-johnson/
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY IE (Carlow) coordinator 187˙866.00

Map

 Project objective

The human gastrointestinal tract harbors a complex community of microorganisms that confer metabolic, immunological and neurological benefits to the host. This assemblage is known as the Gut Microbiome and has received increased attention over the last decade. Scientists have begun to uncover the importance of these bacterial inhabitants and expand investigations to consider how site-specific microbiomes affect host physiology. While more than one million cholecystectomies (gallbladder removal surgeries) are performed throughout Europe each year, the bacterial communities associated with the human gallbladder and its disease states remain unknown. Studies are lacking that characterize the effects of cholecystectomies on the gut microbiome. Without the ability to regulate bile entering the duodenum during food intake, it is expected that gallbladder removal will lead to downstream changes in the intestinal population. Here, the microbial composition of human bile, gallbladder mucosa, and biopsies of surgically removed healthy gallbladders (adherent and non-adherent microbiota) will be investigated using 16S rRNA metagenomics. The profiles will be compared to samples of a second cohort undergoing emergency cholecystectomies, in order to identify possible biomarkers for gallbladder disease. Once the gallbladder microbiome has been elucidated, the impact of its removal on the gut microbiome will be assessed. Using molecular and cultivation based techniques, on stool samples (collected during the recovery period) and analyzed for community composition, metabolomics, bile, fat and energy content. GallBiome will form the basis for establishing relationships between gallbladder microbiota, gut microbiota, and human health with a view to informing future development of diagnostics and therapeutics. Ultimately, characterization of the core gallbladder microbiome has important biological and medical implications with potential to lower the risk and incidence of cholelithiasis.

 Publications

year authors and title journal last update
List of publications.
2018 Crystal Johnson, Criostoir O’Suilleabhain, Paul Ross, Catherine Stanton
The Human GallBiome, At The Interface of Hepatic Health and Disease
published pages: , ISSN: , DOI:
International Symposium of the International Scientific Association of Probiotics and Prebiotics 2019-06-13

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