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GallBiome

Characterization of the Human Gallbladder Microbiome

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GallBiome project word cloud

Explore the words cloud of the GallBiome project. It provides you a very rough idea of what is the project "GallBiome" about.

surgeries    undergoing    period    content    medical    metabolic    human    gallbladders    downstream    microbiomes    removed    profiles    tract    gastrointestinal    received    investigations    microbiota    incidence    form    gallbladder    characterization    benefits    molecular    disease    implications    gut    cholecystectomies    inhabitants    cultivation    duodenum    scientists    begun    intake    performed    basis    microbial    bacterial    stool    health    samples    composition    bile    fat    communities    gallbiome    unknown    community    expand    surgically    informing    elucidated    site    view    microbiome    last    healthy    uncover    biomarkers    risk    intestinal    lower    establishing    collected    population    decade    immunological    biopsies    emergency    removal    metagenomics    entering    food    relationships    adherent    therapeutics    host    lacking    rrna    regulate    cohort    confer    energy    harbors    microorganisms    ultimately    metabolomics    biological    techniques    cholelithiasis    core    neurological    million    recovery    once    physiology    mucosa    assemblage    diagnostics    16s   

Project "GallBiome" data sheet

The following table provides information about the project.

Coordinator
TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY 

Organization address
address: Oak Park
city: Carlow
postcode: R93
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://apc.ucc.ie/profile-dr-crystal-johnson/
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY IE (Carlow) coordinator 187˙866.00

Map

 Project objective

The human gastrointestinal tract harbors a complex community of microorganisms that confer metabolic, immunological and neurological benefits to the host. This assemblage is known as the Gut Microbiome and has received increased attention over the last decade. Scientists have begun to uncover the importance of these bacterial inhabitants and expand investigations to consider how site-specific microbiomes affect host physiology. While more than one million cholecystectomies (gallbladder removal surgeries) are performed throughout Europe each year, the bacterial communities associated with the human gallbladder and its disease states remain unknown. Studies are lacking that characterize the effects of cholecystectomies on the gut microbiome. Without the ability to regulate bile entering the duodenum during food intake, it is expected that gallbladder removal will lead to downstream changes in the intestinal population. Here, the microbial composition of human bile, gallbladder mucosa, and biopsies of surgically removed healthy gallbladders (adherent and non-adherent microbiota) will be investigated using 16S rRNA metagenomics. The profiles will be compared to samples of a second cohort undergoing emergency cholecystectomies, in order to identify possible biomarkers for gallbladder disease. Once the gallbladder microbiome has been elucidated, the impact of its removal on the gut microbiome will be assessed. Using molecular and cultivation based techniques, on stool samples (collected during the recovery period) and analyzed for community composition, metabolomics, bile, fat and energy content. GallBiome will form the basis for establishing relationships between gallbladder microbiota, gut microbiota, and human health with a view to informing future development of diagnostics and therapeutics. Ultimately, characterization of the core gallbladder microbiome has important biological and medical implications with potential to lower the risk and incidence of cholelithiasis.

 Publications

year authors and title journal last update
List of publications.
2018 Crystal Johnson, Criostoir O’Suilleabhain, Paul Ross, Catherine Stanton
The Human GallBiome, At The Interface of Hepatic Health and Disease
published pages: , ISSN: , DOI:
International Symposium of the International Scientific Association of Probiotics and Prebiotics 2019-06-13

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