Opendata, web and dolomites

eXcape3D SIGNED

Functional dissection of X-linked regulatory DNA: unravelling the impact of genome topology on transcriptional regulation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 eXcape3D project word cloud

Explore the words cloud of the eXcape3D project. It provides you a very rough idea of what is the project "eXcape3D" about.

roles    exact    direct    linked    sub    structure    excellence    professional    cells    first    consequence    largely    entire    genome    topology    subset    successfully    topologically    appear    unknown    valuable    resist    chromosomes    coding    combining    model    interacting    capture    expert    skills    relevance    tads    insights    radically    personal    landscapes    genes    interactions    link    associating    regulated    aberrant    shown    considering    conformation    networks    genomes    advancing    scientific    regulatory    team    shared    divided    chromosomal    scientist    inactivation    mammalian    silencing    compensation    regulation    transcriptomic    patterns    gene    female    combination    functional    tendency    chromosome    3d    background    chromatin    epigenetic    structurally    area    opportunity    functionally    xci    expression    qualified    dosage    disrupting    nucleus    co    complementary    host    organisation    suggesting    characterise    transcriptional    mechanism    self    tad    promises    manipulation    discrete    boundaries    innovative    structural    domains    tools    outstanding   

Project "eXcape3D" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 174˙806.00

Map

 Project objective

Mammalian genomes are structurally organized into sub-chromosomal self-interacting domains called topologically associating domains (TADs). Functionally, genes embedded within the same TAD appear to be co-regulated by their shared regulatory landscapes, suggesting the tendency of the genome to be divided into discrete regulatory domains. Although disrupting TAD boundaries has been shown to result in aberrant patterns of gene expression, whether TAD organisation is cause or consequence of transcriptional activity remains largely unknown, as well as the regulatory elements that direct TAD formation and long-range chromatin interactions within TADs. This project aims to define the exact functional link between genome topology and transcriptional regulation by exploiting the mammalian dosage compensation mechanism X-Chromosome Inactivation (XCI) as a model system. First, I will identify the combination of regulatory elements that allow a subset of X-linked genes to resist the transcriptional silencing of one entire X chromosome in female cells. Then, I will characterise their functional and structural relevance by combining advanced epigenetic tools for the manipulation of complex regulatory networks with transcriptomic analysis and chromosome conformation capture, an innovative method that allows to define the 3D structure of chromosomes within the nucleus. This project represents a unique opportunity to enhance our understanding of genome topology, providing valuable insights into the roles of the non-coding genome in gene regulation. Considering my personal professional background, and the outstanding level of scientific excellence of the host institution, this project promises a great potential of radically advancing the field and, in addition, will provide the European Research Area with a highly-qualified expert scientist who has the technical and complementary skills to successfully lead a European research team.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EXCAPE3D" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EXCAPE3D" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

miR-IBD (2019)

Fecal miRNAs, new mediators of host-microbiota interaction in Inflammatory Bowel Disease

Read More  

TIPTOP (2019)

Tensoring Positive Maps on Operator Structures

Read More