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eXcape3D SIGNED

Functional dissection of X-linked regulatory DNA: unravelling the impact of genome topology on transcriptional regulation

Total Cost €

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EC-Contrib. €

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Partnership

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 eXcape3D project word cloud

Explore the words cloud of the eXcape3D project. It provides you a very rough idea of what is the project "eXcape3D" about.

disrupting    capture    chromatin    innovative    structurally    team    tad    patterns    link    interactions    considering    model    consequence    genome    expert    transcriptomic    divided    chromosome    genomes    chromosomes    entire    regulation    structural    chromosomal    topologically    genes    subset    xci    landscapes    nucleus    expression    regulatory    boundaries    networks    host    combining    gene    shown    self    aberrant    professional    co    compensation    outstanding    characterise    transcriptional    tools    dosage    roles    personal    associating    appear    conformation    successfully    linked    skills    organisation    topology    functionally    mechanism    suggesting    largely    shared    structure    manipulation    valuable    exact    scientific    area    scientist    resist    domains    background    female    cells    radically    tads    3d    opportunity    promises    advancing    qualified    insights    functional    mammalian    first    relevance    coding    excellence    discrete    regulated    interacting    unknown    inactivation    sub    direct    tendency    complementary    epigenetic    combination    silencing   

Project "eXcape3D" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 174˙806 €
 EC max contribution 174˙806 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 174˙806.00

Map

 Project objective

Mammalian genomes are structurally organized into sub-chromosomal self-interacting domains called topologically associating domains (TADs). Functionally, genes embedded within the same TAD appear to be co-regulated by their shared regulatory landscapes, suggesting the tendency of the genome to be divided into discrete regulatory domains. Although disrupting TAD boundaries has been shown to result in aberrant patterns of gene expression, whether TAD organisation is cause or consequence of transcriptional activity remains largely unknown, as well as the regulatory elements that direct TAD formation and long-range chromatin interactions within TADs. This project aims to define the exact functional link between genome topology and transcriptional regulation by exploiting the mammalian dosage compensation mechanism X-Chromosome Inactivation (XCI) as a model system. First, I will identify the combination of regulatory elements that allow a subset of X-linked genes to resist the transcriptional silencing of one entire X chromosome in female cells. Then, I will characterise their functional and structural relevance by combining advanced epigenetic tools for the manipulation of complex regulatory networks with transcriptomic analysis and chromosome conformation capture, an innovative method that allows to define the 3D structure of chromosomes within the nucleus. This project represents a unique opportunity to enhance our understanding of genome topology, providing valuable insights into the roles of the non-coding genome in gene regulation. Considering my personal professional background, and the outstanding level of scientific excellence of the host institution, this project promises a great potential of radically advancing the field and, in addition, will provide the European Research Area with a highly-qualified expert scientist who has the technical and complementary skills to successfully lead a European research team.

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The information about "EXCAPE3D" are provided by the European Opendata Portal: CORDIS opendata.

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