Explore the words cloud of the HGTCODONUSE project. It provides you a very rough idea of what is the project "HGTCODONUSE" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||1˙992˙366 €|
|EC max contribution||1˙992˙366 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-06-01 to 2021-05-31|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||1˙992˙366.00|
The intensive use of antibiotics provided an unprecedented improvement in infectious disease treatments but at the expense of creating ideal conditions for the selection of widespread resistance. Propagation of antibiotic resistances is favoured by horizontal gene transfer and by bacterial life in multispecies community. However, compositions of resistome and bacterial communities are often correlated, suggesting that propagation of resistances does not occur at random. This project will test the hypothesis that mismatch in codon preferences between the transferred genes and the receiving genome is a fundamental factor shaping resistome structure and evolution. Such central role of codon preferences may have been hitherto overlooked. The project combines mutant collection characterization, experimental evolution approaches –one in a multispecies context and one in a variable environment context-, full genome sequencing of evolved populations, phylogenomics and mathematical modelling integrating the experimental results of the other approaches, and generating a predictive tool about the evolutionary outcome of various real-life situations.
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The information about "HGTCODONUSE" are provided by the European Opendata Portal: CORDIS opendata.