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InnateMSDyn SIGNED

Combining in vivo spectral biphoton imaging and multiparametric cytometry to characterize the dynamics of the innate immune response in a multiple sclerosis mouse model

Total Cost €

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EC-Contrib. €

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Partnership

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Project "InnateMSDyn" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE D'AIX MARSEILLE 

Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://www.youtube.com/watch
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2018-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 173˙076.00

Map

 Project objective

Multiple sclerosis (MS) disease is dependent on an intricate interplay between the adaptive and innate immune systems. Nevertheless, none of the Food and Drug Administration-approved drugs target innate immune cells, because of their unclear roles in the disease process. However, innate immune cells implication in the MS disease is no longer put in doubt. The mobilization, differentiation and spatial-temporal distribution of brain resident and recruited peripheral innate immune cells, in relation with clinical scores, will be analyzed, as an alternative source of disease biomarkers and therapeutic targets. The project combines recent advances in (a) generation of multicolor transgenic reporter mice with subpopulations of cells expressing distinct fluorophores, (b) spectral bi-photon imaging to visualize the cells of interest directly in the spinal cord in living animals, at a subcellular resolution in real time, and (c) multiparametric flow cytometry to characterize over time inflammatory cell types in the spinal cord tissue after disease induction. The activated cells converging to the neuronal lesions, as well as the delay and the effect on the neurons, will be characterized. VEGF will also be tested as potential therapeutic drug, based on the known VEGF effects on neurons and immune cells. This data will provide new insights on MS disease setting up and implicated cells, correlated with clinical scores, neuronal damages and disease progression.

 Publications

year authors and title journal last update
List of publications.
2018 Céline Caravagna, Alexandre Jaouën, Sophie Desplat-Jégo, Keith K. Fenrich, Elise Bergot, Hervé Luche, Pierre Grenot, Geneviève Rougon, Marie Malissen, Franck Debarbieux
Diversity of innate immune cell subsets across spatial and temporal scales in an EAE mouse model
published pages: 5146, ISSN: 2045-2322, DOI: 10.1038/s41598-018-22872-y
Scientific Reports 8/1 2019-06-13

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