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BAC-STAR SIGNED

Bacterial Adhesion Control through Surface TArgeted Regulation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BAC-STAR project word cloud

Explore the words cloud of the BAC-STAR project. It provides you a very rough idea of what is the project "BAC-STAR" about.

fuel    pathogens    create    bacteria    charge    electrodes    ultimate    implants    mimic    specialised    electrogens    cells    tested    kinetics    base    fluorescence    time    tissue    nutrient    pathogen    mutagenesis    plate    facilitates    elisas    library    preventing    bacterial    mixed    immunofluorescence    materials    spectrum    coli    expressing    functionalization    feedback    roughness    interactions    assay    culture    investigations    exchange    recombinant    flow    host    pure    gradually    expressed    adhesin    western    hydrophobicity    shear    microscopy    generates    loop    surface    oral    clones    transferability    microbial    surfaces    modifications    knockouts    improvement    porosity    cell    interaction    ing    monitored    knockout    gingival    genes    blotting    directed    wild    entire    human    composition    antifouling    complement    assays    adhesion    osteoblast    vivo    engineering    stress    adhesins    variety    framework    strains    interdisciplinary    fundamental    whilst   

Project "BAC-STAR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I OSLO 

Organization address
address: PROBLEMVEIEN 5-7
city: OSLO
postcode: 313
website: www.uio.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 208˙400 €
 EC max contribution 208˙400 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-12-18

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I OSLO NO (OSLO) coordinator 208˙400.00

Map

 Project objective

Fundamental investigations of bacterial adhesion will create the knowledge base to advance surface engineering approaches. Directed mutagenesis of adhesin genes in several oral pathogens will be used to create a library of knockout strains. Recombinant adhesins will also be over-expressed in E.coli. Assays will be developed to test the interaction of the resulting strains (wild-type, knockouts, over-expressing E.coli clones) with a range of materials, covering the entire spectrum of surface properties with defined roughness, hydrophobicity, porosity, charge and composition. Adhesion kinetics will be monitored in real time, using flow cells to mimic the shear stress and nutrient exchange on implants in vivo. This will complement plate-based fluorescence adhesion assays, western blotting, immunofluorescence microscopy, and ELISAs. Adhesion trends will be tested with targeted surface modifications in pure and mixed culture, creating a feedback-loop for assay improvement with gradually specialised surface functionalization. The ultimate goal is to develop surfaces that promote the adhesion of host tissue, such as human osteoblast cells or gingival cells, whilst still preventing pathogen adhesion. Understanding the fundamental interactions of bacteria with surfaces facilitates the transferability of the results from this project to a variety of further applications (e.g. adhesion of electrogens to microbial fuel cell electrodes; antifouling surfaces etc.). My proposal therefore has the potential to be high impact research, and generates the framework for future interdisciplinary projects.

 Publications

year authors and title journal last update
List of publications.
2019 Nandini Chauhan, Daniel Hatlem, Marcella Orwick-Rydmark, Kenneth Schneider, Matthias Floetenmeyer, Barth van Rossum, Jack C. Leo, Dirk Linke
Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA)
published pages: 844-862, ISSN: 0950-382X, DOI: 10.1111/mmi.14195
Molecular Microbiology 111/3 2020-02-13

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