Explore the words cloud of the BAC-STAR project. It provides you a very rough idea of what is the project "BAC-STAR" about.
The following table provides information about the project.
UNIVERSITETET I OSLO
|Coordinator Country||Norway [NO]|
|Total cost||208˙400 €|
|EC max contribution||208˙400 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-09-01 to 2019-12-18|
Take a look of project's partnership.
Fundamental investigations of bacterial adhesion will create the knowledge base to advance surface engineering approaches. Directed mutagenesis of adhesin genes in several oral pathogens will be used to create a library of knockout strains. Recombinant adhesins will also be over-expressed in E.coli. Assays will be developed to test the interaction of the resulting strains (wild-type, knockouts, over-expressing E.coli clones) with a range of materials, covering the entire spectrum of surface properties with defined roughness, hydrophobicity, porosity, charge and composition. Adhesion kinetics will be monitored in real time, using flow cells to mimic the shear stress and nutrient exchange on implants in vivo. This will complement plate-based fluorescence adhesion assays, western blotting, immunofluorescence microscopy, and ELISAs. Adhesion trends will be tested with targeted surface modifications in pure and mixed culture, creating a feedback-loop for assay improvement with gradually specialised surface functionalization. The ultimate goal is to develop surfaces that promote the adhesion of host tissue, such as human osteoblast cells or gingival cells, whilst still preventing pathogen adhesion. Understanding the fundamental interactions of bacteria with surfaces facilitates the transferability of the results from this project to a variety of further applications (e.g. adhesion of electrogens to microbial fuel cell electrodes; antifouling surfaces etc.). My proposal therefore has the potential to be high impact research, and generates the framework for future interdisciplinary projects.
|year||authors and title||journal||last update|
Nandini Chauhan, Daniel Hatlem, Marcella Orwick-Rydmark, Kenneth Schneider, Matthias Floetenmeyer, Barth van Rossum, Jack C. Leo, Dirk Linke
Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA)
published pages: 844-862, ISSN: 0950-382X, DOI: 10.1111/mmi.14195
|Molecular Microbiology 111/3||2020-02-13|
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The information about "BAC-STAR" are provided by the European Opendata Portal: CORDIS opendata.
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