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HIT-LVAD SIGNED

Understanding blood pressure and vascular haemodynamics in implanted Left Ventricular Assist Device patients.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "HIT-LVAD" data sheet

The following table provides information about the project.

Coordinator
CARDIFF METROPOLITAN UNIVERSITY 

Organization address
address: WESTERN AVENUE 200 LLANDAFF
city: CARDIFF
postcode: CF5 2YB
website: www.uwic.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.researchgate.net/project/HIT-LVAD-Trial
 Total cost 251˙857 €
 EC max contribution 251˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF METROPOLITAN UNIVERSITY UK (CARDIFF) coordinator 251˙857.00
2    TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK US (NEW YORK) partner 0.00

Map

 Project objective

Background: Advanced heart failure (HF) is a growing health problem in the European Union (EU). Consequently, a growing number of HF patients now depend on state-of-the-art continuous flow Left Ventricular Assist Devices (cf-LVAD) as a bridge to transplant or as a means of destination therapy. Since the introduction and usage of cf-LVAD’s rather than traditional pulsatile LVAD’s, survival rates have significantly improved. However, an increased number of side-effects, including stroke and microvascular bleeding, have been reported. Suggested mechanisms associated with these side effects is lack of pulsatile pressure and flow throughout the system, however there are currently no data on macro/micro haemodynamics in these patients. Objectives: Columbia University’s Medical Center (CUMC) has the largest cf-LVAD programme in the world and thus will enable recruitment and assessment of the largest cohort to date of cf-LVAD patients. The aim of the project is to provide 5 work packages (WP) to understand the consequences of decreased pulsatile blood pressure (BP) and flow haemodynamics in cf-LVAD patients, compared to HF patients and age matched controls. Protocol: WP1:Measurement of BP and haemodynamics in cf-LVAD patients, using a new innovative BP device. WP2:Measurement of microvascular flow profiles in cf-LVAD patients, HF patients and healthy controls, using transcranial Doppler ultrasound and high frequency retinal Doppler ultrasound. WP3:Validation of brachial BP in cf-LVAD patients. WP4:Development of an improved LVAD device. WP5:Re-integration and Transfer of Knowledge back into the EU. Outcome: The project will require the fellow to re-integrate and transfer ALL of the newly acquired knowledge and skills from the world leading institution of CUMC back to the host institution, local community, national and EU clinical and industrial partners. This will facilitate the fellow to become a leading European authority in haemodynamics associated with LVAD patients.

 Publications

year authors and title journal last update
List of publications.
2019 Eric J. Stöhr
Bionic Women and Men: Heart failure and an artificial heart pump.
published pages: , ISSN: 2399-1542, DOI:
ResearchFeatures 2019-10-29
2019 Alberto Pinsino, Francesco Castagna, Amelia M. Zuver, Eugene A. Royzman, Mojdeh Nasiri, Eric J. Stöhr, Barbara Cagliostro, Barry McDonnell, John R. Cockcroft, A. Reshad Garan, Veli K. Topkara, P. Christian Schulze, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Ryan T. Demmer, Joshua Z. Willey, Melana Yuzefpolskaya, Paolo C. Colombo
Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device
published pages: 396-405, ISSN: 1053-2498, DOI: 10.1016/j.healun.2018.11.003
The Journal of Heart and Lung Transplantation 38/4 2019-10-29
2017 Francesco Castagna, Eric J. Stöhr, Alberto Pinsino, John R. Cockcroft, Joshua Willey, A. Reshad Garan, Veli K. Topkara, Paolo C. Colombo, Melana Yuzefpolskaya, Barry J. McDonnell
The Unique Blood Pressures and Pulsatility of LVAD Patients: Current Challenges and Future Opportunities
published pages: , ISSN: 1522-6417, DOI: 10.1007/s11906-017-0782-6
Current Hypertension Reports 19/10 2019-06-13
2018 Estibaliz Castillero, Ziad A Ali, Hirokazu Akashi, Nicholas Giangreco, Catherine Wang, Eric Jean Stöhr, Ruiping Ji, Xiaokan Zhang, Nathaniel Kheysin, Joo-Eun S Park, Sheetal Hegde, Sanatkumar Patel, Samantha Stein, Carlos Cuenca, Diana Leung, Shunichi Homma, Nicholas P Tatonetti, Veli Topkara, Koji Takeda, Paolo C Colombo, Yoshifumi Naka, H Lee Sweeney, P. Christian Schulze, Isaac George
Structural and Functional Cardiac Profile after Prolonged Duration of Mechanical Unloading: Potential Implications for Myocardial Recovery
published pages: , ISSN: 0363-6135, DOI: 10.1152/ajpheart.00187.2018
American Journal of Physiology-Heart and Circulatory Physiology 2019-05-08
2017 Francesco Castagna, Barry J. McDonnell, Eric J. Stöhr, Melana Yuzefpolskaya, Pauline N. Trinh, Veli K. Topkara, A. Reshad Garan, Margaret A. Flannery, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Ryan T. Demmer, Siegfried Wassertheurer, John Cockcroft, Paolo C. Colombo
Non-invasive measurement of peripheral, central and 24-hour blood pressure in patients with continuous-flow left ventricular assist device
published pages: 694-697, ISSN: 1053-2498, DOI: 10.1016/j.healun.2017.02.026
The Journal of Heart and Lung Transplantation 36/6 2019-05-08
2018 Eric J.Stöhr, HirooTakayama, Giovanni Ferrari
Stretch your heart—but not too far: The role of titin mutations in dilated cardiomyopathy
published pages: , ISSN: 0022-5223, DOI:
The Journal of Thoracic and Cardiovascular Surgery 2019-05-08
2018 Eric J. Stöhr, Barry J. McDonnell, Paolo C. Colombo, Joshua Z. Willey
Blood Flow Pulsatility in LVAD Patients isessential to Maintain Normal Brain Physiology
published pages: , ISSN: 0022-3751, DOI:
Journal of Physiology 2019-05-08
2018 Eric J. Stöhr, Barry J. McDonnell, Paolo C. Colombo, Joshua Z. Willey
Rebuttal from:
published pages: , ISSN: 0022-3751, DOI:
Journal of Physiology 2019-05-08

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