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Farewell flashbacks

Developing science-driven therapies after trauma: Neural mechanisms underlying the modification of intrusive emotional memories

Total Cost €

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EC-Contrib. €

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Partnership

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 Farewell flashbacks project word cloud

Explore the words cloud of the Farewell flashbacks project. It provides you a very rough idea of what is the project "Farewell flashbacks" about.

skills    trauma    stress    conferences    supervisors    neuroimaging    establishment    emily    memory    fmri    interference    science    extreme    world    cambridge    methodological    ing    tetris    posttraumatic    memories    prof    intrusions    training    film    mri    symptom    fuel    engaging    grant    understand    disorder    therapies    underlying    psychology    disorders    clinical    flashbacks    lab    retrieval    experimental    interventions    me    mental    labile    involuntary    cbu    visuospatial    emotional    multidisciplinary    fellowship    media    scientific    holmes    sciences    modulation    supervisor    effect    footage    event    content    brain    lacking    intrusive    susceptible    form    traumatic    combining    transferrable    neuroscience    fewer    prevent    enter    recurrent    mrc    innovative    yield    mechanisms    basis    career    acquired    medical    premier    hallmark    treating    cognition    courses    retrieving    showing    subsequent    finds    conceptual    health    network    psychiatric    neural    consolidated    aversive    papers    insights    disrupted    leader    council    disseminating    basic    scientists    reconsolidation   

Project "Farewell flashbacks" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
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email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.mrc-cbu.cam.ac.uk/people/renee.visser/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 114˙015.00
2    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 81˙439.00

Map

 Project objective

A hallmark symptom of posttraumatic stress disorder involves ‘recurrent, involuntary and intrusive memories of the traumatic event’, in their most extreme form referred to as ‘flashbacks’. At present, effective interventions to prevent the development of intrusive memory after trauma are lacking. The research aim is to develop innovative, science-based therapies for treating trauma-related psychiatric disorders, by using a multidisciplinary approach, combining advanced neuroimaging (fMRI) analyses with an experimental analogue for trauma (film footage with aversive content). Key to the proposed research are findings from basic neuroscience showing that consolidated memories can - upon their retrieval – enter a labile state, making them susceptible to interference. Recent finds from the supervisors lab show that the reconsolidation of trauma memory can be disrupted, resulting in fewer subsequent intrusions, by engaging participants in a visuospatial task (i.e., Tetris) after retrieving the memory. To understand the mechanisms underlying this effect, I aim to directly measure the neural processes involved in the modulation of consolidated emotional memory. This has the potential to yield major conceptual, clinical and methodological insights, and will advance my research skills. The acquired transferrable knowledge will form the basis of a future grant application fully supported by the supervisor, prof. Emily Holmes, towards the end of the fellowship and fuel my career as a future leader in mental health science. My training will include courses on advanced MRI, media training and project management, and disseminating my results through scientific papers, conferences, and the media. A fellowship at the Medical Research Council (MRC) Cognition and Brain Sciences Unit (CBU) in Cambridge would help me establish an network with leading scientists from all over the world, while being based at a premier establishment for clinical psychology research and neuroscience.

 Publications

year authors and title journal last update
List of publications.
2018 Renée M. Visser, Alex Lau-Zhu, Richard N. Henson, Emily A. Holmes
Multiple memory systems, multiple time points: how science can inform treatment to control the expression of unwanted emotional memories
published pages: 20170209, ISSN: 0962-8436, DOI: 10.1098/rstb.2017.0209
Philosophical Transactions of the Royal Society B: Biological Sciences 373/1742 2019-06-13
2018 Guy M. Goodwin, Emily A. Holmes, Erik Andersson, Michael Browning, Andrew Jones, Johanna Lass-Hennemann, Kristoffer NT Månsson, Carolin Moessnang, Elske Salemink, Alvaro Sanchez, Linda van Zutphen, Renée M. Visser
From neuroscience to evidence based psychological treatments – The promise and the challenge, ECNP March 2016, Nice, France
published pages: 317-333, ISSN: 0924-977X, DOI: 10.1016/j.euroneuro.2017.10.036
European Neuropsychopharmacology 28/2 2019-06-13
2018 Dieuwke Sevenster, Renée M. Visser, Rudi D\'Hooge
A translational perspective on neural circuits of fear extinction: Current promises and challenges
published pages: 113-126, ISSN: 1074-7427, DOI: 10.1016/j.nlm.2018.07.002
Neurobiology of Learning and Memory 155 2019-06-13
2018 Lalitha Iyadurai, Renée M. Visser, Alex Lau-Zhu, Kate Porcheret, Antje Horsch, Emily A. Holmes, Ella L. James
Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application
published pages: , ISSN: 0272-7358, DOI: 10.1016/j.cpr.2018.08.005
Clinical Psychology Review 2019-05-22
2018 Michelle I. C. de Haan, Sonja van Well, Renée M. Visser, H. Steven Scholte, Guido A. van Wingen, Merel Kindt
The influence of acoustic startle probes on fear learning in humans
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32646-1
Scientific Reports 8/1 2019-05-22

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