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AS-ABA SIGNED

Alternative splicing and SR proteins in ABA-mediated plant stress responses

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 AS-ABA project word cloud

Explore the words cloud of the AS-ABA project. It provides you a very rough idea of what is the project "AS-ABA" about.

rip    environmental    pave    crop    plant    gene    regulating    expressing    mechanism    eukaryotes    play    protein    arginine    seq    hormone    mounting    aba    drought    efficient    alternative    technologies    suggests    stress    of    mediated    rna    causes    subcellular    posttranscriptional    binding    arabidopsis    world    largely    genes    generation    tagged    central    plants    sr    proteins    relevance    localization    mechanistic    revealing    transcriptome    regulation    mechanisms    productivity    six    combination    worldwide    unknown    biochemical    molecular    unfavorable    hormonal    discovering    levels    expanding    gain    plays    underlying    acid    regulated    flexible    implicated    brief    pervasive    altered    reverse    sequencing    cope    proteome    splicing    regions    genome    version    action    tolerance    genetics    mode    physiological    functional    transcripts    phytohormone    immunoprecipitation    diversity    salinity    strategies    abiotic    abscisic    roles    expression    serine    significance   

Project "AS-ABA" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO CALOUSTE GULBENKIAN 

Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000
website: www.igc.gulbenkian.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.igc.gulbenkian.pt/pduque
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 148˙635.00

Map

 Project objective

Abscisic acid (ABA), the major plant stress hormone, plays a crucial role in the response to the most pervasive causes of loss of crop productivity worldwide, including drought and high salinity. Serine/arginine-rich (SR) proteins are RNA-binding proteins that play crucial roles in the regulation of alternative splicing (AS), a key posttranscriptional mechanism for expanding proteome diversity and a flexible means of regulating gene expression in higher eukaryotes. While its functional relevance in plants remains largely unknown, mounting evidence suggests a central role for AS in the response to abiotic stress, in particular by targeting the ABA hormonal pathway. Using gene expression analyses, subcellular localization studies and reverse genetics approaches, this project will investigate the functional significance of six ABA-regulated Arabidopsis SR genes in stress responses mediated by the ABA phytohormone. To gain mechanistic insight into the mode of action of the SR proteins implicated in the ABA pathway, the physiological transcripts targeted by these splicing factors to achieve plant stress tolerance will be identified using a combination of genome-wide and biochemical approaches. In brief, next-generation sequencing technologies will be applied to whole transcriptome analysis (RNA-seq) of plants with altered levels of an SR protein and to RNA immunoprecipitation (RIP-seq) in plants expressing a tagged version of the SR protein. In discovering new plant genes that determine the ability to cope with unfavorable environmental conditions and by revealing the molecular mechanisms underlying their mode of action, this work will pave the way for the development of new efficient strategies to improve crop productivity in specific world regions.

 Publications

year authors and title journal last update
List of publications.
2018 Tom Laloum, Guiomar Martín, Paula Duque
Alternative Splicing Control of Abiotic Stress Responses
published pages: 140-150, ISSN: 1360-1385, DOI: 10.1016/j.tplants.2017.09.019
Trends in Plant Science 23/2 2019-10-31

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