EU H2020 Project "AS-ABA (Alternative splicing and SR proteins in ABA-mediated plant stress responses)": description, partecipants, costs and EC-fundings

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AS-ABA project word cloud

Explore the words cloud of the AS-ABA project. It provides you a very rough idea of what is the project "AS-ABA" about.

gene rna mounting world discovering plays arabidopsis technologies of unknown biochemical regulation expanding acid arginine generation mechanisms altered suggests posttranscriptional expression regulating levels functional crop worldwide abscisic hormonal mediated binding causes plants flexible genetics mechanistic play physiological action mode gain aba expressing serine immunoprecipitation localization seq salinity protein revealing pave sr sequencing tagged cope tolerance splicing pervasive proteome drought regions genome phytohormone mechanism relevance roles rip central eukaryotes abiotic environmental molecular implicated efficient transcripts unfavorable subcellular underlying productivity plant genes brief proteins hormone combination stress strategies transcriptome reverse diversity version regulated largely six alternative significance

Project "AS-ABA" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA BERNA 45 city: LISBOA postcode: 1000 website: www.igc.gulbenkian.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://www.igc.gulbenkian.pt/pduque
Total cost	148˙635 €
EC max contribution	148˙635 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-08-31

#	participants	country	role	EC contrib. [€]
1	FUNDACAO CALOUSTE GULBENKIAN	PT (LISBOA)	coordinator	148˙635.00

FUNDACAO CALOUSTE GULBENKIAN

PT (LISBOA)

coordinator

148˙635.00

Project objective

Abscisic acid (ABA), the major plant stress hormone, plays a crucial role in the response to the most pervasive causes of loss of crop productivity worldwide, including drought and high salinity. Serine/arginine-rich (SR) proteins are RNA-binding proteins that play crucial roles in the regulation of alternative splicing (AS), a key posttranscriptional mechanism for expanding proteome diversity and a flexible means of regulating gene expression in higher eukaryotes. While its functional relevance in plants remains largely unknown, mounting evidence suggests a central role for AS in the response to abiotic stress, in particular by targeting the ABA hormonal pathway. Using gene expression analyses, subcellular localization studies and reverse genetics approaches, this project will investigate the functional significance of six ABA-regulated Arabidopsis SR genes in stress responses mediated by the ABA phytohormone. To gain mechanistic insight into the mode of action of the SR proteins implicated in the ABA pathway, the physiological transcripts targeted by these splicing factors to achieve plant stress tolerance will be identified using a combination of genome-wide and biochemical approaches. In brief, next-generation sequencing technologies will be applied to whole transcriptome analysis (RNA-seq) of plants with altered levels of an SR protein and to RNA immunoprecipitation (RIP-seq) in plants expressing a tagged version of the SR protein. In discovering new plant genes that determine the ability to cope with unfavorable environmental conditions and by revealing the molecular mechanisms underlying their mode of action, this work will pave the way for the development of new efficient strategies to improve crop productivity in specific world regions.

Publications

List of publications.
year	authors and title	journal	last update
2018	Tom Laloum, Guiomar MartÃn, Paula Duque Alternative Splicing Control of Abiotic Stress Responses published pages: 140-150, ISSN: 1360-1385, DOI: 10.1016/j.tplants.2017.09.019	Trends in Plant Science 23/2	2019-10-31

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