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Alternative splicing and SR proteins in ABA-mediated plant stress responses

Total Cost €


EC-Contrib. €






 AS-ABA project word cloud

Explore the words cloud of the AS-ABA project. It provides you a very rough idea of what is the project "AS-ABA" about.

of    gene    tolerance    localization    unknown    arabidopsis    biochemical    salinity    proteome    worldwide    mounting    causes    protein    eukaryotes    mode    serine    discovering    genes    efficient    strategies    arginine    revealing    transcripts    sequencing    brief    generation    significance    hormone    action    expanding    six    expression    transcriptome    drought    aba    mediated    physiological    cope    sr    world    version    alternative    largely    pervasive    posttranscriptional    phytohormone    abiotic    regions    expressing    mechanism    seq    regulated    gain    underlying    plant    mechanistic    molecular    pave    combination    proteins    relevance    reverse    immunoprecipitation    productivity    diversity    genome    central    unfavorable    implicated    altered    genetics    regulating    rna    tagged    environmental    binding    mechanisms    regulation    roles    technologies    suggests    plants    stress    rip    subcellular    plays    abscisic    play    crop    hormonal    levels    flexible    functional    acid    splicing   

Project "AS-ABA" data sheet

The following table provides information about the project.


Organization address
address: AVENIDA BERNA 45
city: LISBOA
postcode: 1000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO CALOUSTE GULBENKIAN PT (LISBOA) coordinator 148˙635.00


 Project objective

Abscisic acid (ABA), the major plant stress hormone, plays a crucial role in the response to the most pervasive causes of loss of crop productivity worldwide, including drought and high salinity. Serine/arginine-rich (SR) proteins are RNA-binding proteins that play crucial roles in the regulation of alternative splicing (AS), a key posttranscriptional mechanism for expanding proteome diversity and a flexible means of regulating gene expression in higher eukaryotes. While its functional relevance in plants remains largely unknown, mounting evidence suggests a central role for AS in the response to abiotic stress, in particular by targeting the ABA hormonal pathway. Using gene expression analyses, subcellular localization studies and reverse genetics approaches, this project will investigate the functional significance of six ABA-regulated Arabidopsis SR genes in stress responses mediated by the ABA phytohormone. To gain mechanistic insight into the mode of action of the SR proteins implicated in the ABA pathway, the physiological transcripts targeted by these splicing factors to achieve plant stress tolerance will be identified using a combination of genome-wide and biochemical approaches. In brief, next-generation sequencing technologies will be applied to whole transcriptome analysis (RNA-seq) of plants with altered levels of an SR protein and to RNA immunoprecipitation (RIP-seq) in plants expressing a tagged version of the SR protein. In discovering new plant genes that determine the ability to cope with unfavorable environmental conditions and by revealing the molecular mechanisms underlying their mode of action, this work will pave the way for the development of new efficient strategies to improve crop productivity in specific world regions.


year authors and title journal last update
List of publications.
2018 Tom Laloum, Guiomar Martín, Paula Duque
Alternative Splicing Control of Abiotic Stress Responses
published pages: 140-150, ISSN: 1360-1385, DOI: 10.1016/j.tplants.2017.09.019
Trends in Plant Science 23/2 2019-10-31

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