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AmnioticID SIGNED

Understanding the identity of the amniotic fluid stem cells

Total Cost €

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EC-Contrib. €

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Partnership

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 AmnioticID project word cloud

Explore the words cloud of the AmnioticID project. It provides you a very rough idea of what is the project "AmnioticID" about.

lineage    relevance    utilised    strategies    curie    mission    translation    muscle    independent    renewing    faceted    regenerative    sequencing    stem    shedding    collaborations    mechanical    combination    medicine    transferrable    valuable    cell    line    direct    agendas    skills    trophic    identity    variety    ideal    cardiac    embryonic    career    human    small    gestation    decade    autologous    me    gaps    implications    liver    tissue    extra    clinical    differentiated    series    therapeutic    function    physiological    afscs    perinatal    liquid    contains    surrounds    tissues    population    2007    seminal    foetus    broad    compartments    cells    international    protects    de    isolated    tracing    ultimately    gain    self    fluid    constantly    generation    skeletal    origin    assays    diagnosis    prenatal    coppi    expanded    professor    questions    linage    last    differentiation    niche    article    list    biology    little    lung    marie    thanks    amniotic    action    releases    vivo    development   

Project "AmnioticID" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The amniotic fluid surrounds and protects the foetus during development, providing trophic and mechanical support to its growth. This liquid contains a variety of cells shedding from embryonic and extra-embryonic tissues that have long been utilised for prenatal diagnosis. In a seminal 2007 article, Professor De Coppi identified in the amniotic fluid, a small population of cells with broad multi-lineage differentiation ability defined as Amniotic Fluid Stem Cells (AFSCs). AFSCs can be isolated, expanded and differentiated during gestation, making them ideal for the development of pre-/perinatal autologous regenerative medicine strategies. In the last decade, a series of studies focused on investigating the therapeutic relevance of the AFSCs for various tissue compartments, such as skeletal and cardiac muscle, lung and liver. However, very little is known about the AFSCs origin, lineage identity and role during human development. This knowledge gaps have relevant impact on these cells' clinical translation and a list of important questions remains to be addressed: Which tissue releases the AFSCs? Are these cells constantly generated, or part of a self-renewing niche? What is the function of the AFSCs during human development? This proposal aims at addressing these questions, by using a combination of next generation sequencing analyses, cell biology assays and in vivo linage tracing approaches. Ultimately defining the origin and identity of the AFSCs will not only increase our knowledge of their physiological role, but will also allow to better direct future studies on their therapeutic implications. Thanks to this project, I will gain a comprehensive, multi-faceted understanding of the biology and regenerative potential of AFSCs. This will open up new research agendas, foster international collaborations and provide me valuable transferrable skills of crucial relevance to develop my independent career, in line with the mission of the Marie Curie action.

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The information about "AMNIOTICID" are provided by the European Opendata Portal: CORDIS opendata.

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