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AmnioticID SIGNED

Understanding the identity of the amniotic fluid stem cells

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 AmnioticID project word cloud

Explore the words cloud of the AmnioticID project. It provides you a very rough idea of what is the project "AmnioticID" about.

broad    assays    vivo    independent    last    linage    liver    questions    coppi    protects    agendas    de    tracing    ultimately    embryonic    shedding    compartments    list    cardiac    variety    implications    expanded    function    career    diagnosis    combination    lung    origin    autologous    2007    foetus    stem    differentiation    therapeutic    clinical    constantly    cells    afscs    extra    gain    perinatal    tissue    faceted    curie    utilised    gestation    direct    decade    me    collaborations    valuable    transferrable    releases    fluid    medicine    niche    tissues    skeletal    skills    strategies    mechanical    self    action    translation    thanks    sequencing    article    human    population    physiological    international    gaps    little    small    cell    biology    marie    trophic    differentiated    mission    muscle    contains    ideal    lineage    amniotic    seminal    generation    isolated    line    liquid    series    renewing    development    identity    surrounds    professor    regenerative    relevance    prenatal   

Project "AmnioticID" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The amniotic fluid surrounds and protects the foetus during development, providing trophic and mechanical support to its growth. This liquid contains a variety of cells shedding from embryonic and extra-embryonic tissues that have long been utilised for prenatal diagnosis. In a seminal 2007 article, Professor De Coppi identified in the amniotic fluid, a small population of cells with broad multi-lineage differentiation ability defined as Amniotic Fluid Stem Cells (AFSCs). AFSCs can be isolated, expanded and differentiated during gestation, making them ideal for the development of pre-/perinatal autologous regenerative medicine strategies. In the last decade, a series of studies focused on investigating the therapeutic relevance of the AFSCs for various tissue compartments, such as skeletal and cardiac muscle, lung and liver. However, very little is known about the AFSCs origin, lineage identity and role during human development. This knowledge gaps have relevant impact on these cells' clinical translation and a list of important questions remains to be addressed: Which tissue releases the AFSCs? Are these cells constantly generated, or part of a self-renewing niche? What is the function of the AFSCs during human development? This proposal aims at addressing these questions, by using a combination of next generation sequencing analyses, cell biology assays and in vivo linage tracing approaches. Ultimately defining the origin and identity of the AFSCs will not only increase our knowledge of their physiological role, but will also allow to better direct future studies on their therapeutic implications. Thanks to this project, I will gain a comprehensive, multi-faceted understanding of the biology and regenerative potential of AFSCs. This will open up new research agendas, foster international collaborations and provide me valuable transferrable skills of crucial relevance to develop my independent career, in line with the mission of the Marie Curie action.

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The information about "AMNIOTICID" are provided by the European Opendata Portal: CORDIS opendata.

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