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AmnioticID SIGNED

Understanding the identity of the amniotic fluid stem cells

Total Cost €

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EC-Contrib. €

0

Partnership

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 AmnioticID project word cloud

Explore the words cloud of the AmnioticID project. It provides you a very rough idea of what is the project "AmnioticID" about.

foetus    utilised    therapeutic    small    generation    compartments    decade    action    me    trophic    combination    isolated    variety    questions    medicine    gestation    skeletal    renewing    regenerative    international    differentiated    mission    professor    surrounds    tracing    releases    gaps    expanded    mechanical    niche    differentiation    valuable    constantly    collaborations    strategies    perinatal    extra    broad    muscle    sequencing    protects    amniotic    assays    development    list    coppi    cells    series    career    transferrable    origin    2007    self    tissue    marie    agendas    lineage    prenatal    implications    linage    liquid    faceted    afscs    autologous    ultimately    independent    embryonic    article    cell    population    biology    physiological    fluid    last    gain    stem    seminal    relevance    curie    line    liver    diagnosis    direct    clinical    lung    thanks    function    vivo    de    tissues    little    shedding    skills    translation    human    ideal    contains    identity    cardiac   

Project "AmnioticID" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 212˙933.00

Map

 Project objective

The amniotic fluid surrounds and protects the foetus during development, providing trophic and mechanical support to its growth. This liquid contains a variety of cells shedding from embryonic and extra-embryonic tissues that have long been utilised for prenatal diagnosis. In a seminal 2007 article, Professor De Coppi identified in the amniotic fluid, a small population of cells with broad multi-lineage differentiation ability defined as Amniotic Fluid Stem Cells (AFSCs). AFSCs can be isolated, expanded and differentiated during gestation, making them ideal for the development of pre-/perinatal autologous regenerative medicine strategies. In the last decade, a series of studies focused on investigating the therapeutic relevance of the AFSCs for various tissue compartments, such as skeletal and cardiac muscle, lung and liver. However, very little is known about the AFSCs origin, lineage identity and role during human development. This knowledge gaps have relevant impact on these cells' clinical translation and a list of important questions remains to be addressed: Which tissue releases the AFSCs? Are these cells constantly generated, or part of a self-renewing niche? What is the function of the AFSCs during human development? This proposal aims at addressing these questions, by using a combination of next generation sequencing analyses, cell biology assays and in vivo linage tracing approaches. Ultimately defining the origin and identity of the AFSCs will not only increase our knowledge of their physiological role, but will also allow to better direct future studies on their therapeutic implications. Thanks to this project, I will gain a comprehensive, multi-faceted understanding of the biology and regenerative potential of AFSCs. This will open up new research agendas, foster international collaborations and provide me valuable transferrable skills of crucial relevance to develop my independent career, in line with the mission of the Marie Curie action.

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The information about "AMNIOTICID" are provided by the European Opendata Portal: CORDIS opendata.

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