Explore the words cloud of the T6S project. It provides you a very rough idea of what is the project "T6S" about.
The following table provides information about the project.
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
|Coordinator Country||Switzerland [CH]|
|Total cost||1˙751˙853 €|
|EC max contribution||1˙751˙853 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
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|1||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||coordinator||1˙751˙853.00|
Transporting selected proteins across the cell envelope in a controlled manner is a fundamental property of all cell types. For bacteria, secretion systems play a central role in the translocation of effectors that mediate interactions with other cells. The bacterial Type VI Secretion (T6S) system is one of the most widespread secretion systems and, in a cell-cell contact-dependent fashion, it injects effectors into eukaryotic and bacterial targets. The T6S system utilizes a cytoplasmic phage tail-like apparatus that is anchored to the cell envelope. A contractile sheath propels a macromolecular effector-loaded tube/spike-complex outside the cell and into the target.
Here, we will establish a model of T6S-mediated cell-cell interactions by integrating information from the molecular, cellular and intercellular scales. The model will reveal answers to three paramount questions of the field: Aim 1 (molecular scale) will elucidate an atomic model of the T6S membrane-anchoring complex in loaded and fired conformational states. Aim 2 (cellular scale) will identify the mechanisms and relevance of clustering multiple T6S machines in a confined region of the cell. Aim 3 (intercellular scale) will resolve T6S actively engaged in cell-cell interactions to clarify the in vivo structure and significance of the inner tube in effector translocation and target cell penetration.
Electron cryo-tomography (ECT) will be used as the key technique to resolve unique structures in their cellular context, in a native state, in three dimensions and at the crucial nanometer-to-micrometer range. Cryo-focused ion beam milling will be established to prepare samples thin enough for ECT imaging. ECT data will be complemented by high-resolution structural information of sub-complexes (in vitro) and low-resolution fluorescence light microscopy data on dynamics (in vivo). In the future, our approach will prove useful to study other types of bacterial cell-cell interactions.
|year||authors and title||journal||last update|
Shujun Cai, DÃ©sirÃ©e BÃ¶ck, Martin Pilhofer, Lu Gan
The in situ structures of mono-, di-, and trinucleosomes in human heterochromatin
published pages: 2450-2457, ISSN: 1059-1524, DOI: 10.1091/mbc.e18-05-0331
|Molecular Biology of the Cell 29/20||2019-09-04|
Masanori Toyofuku, Gerardo CÃ¡rcamo-Oyarce, Tatsuya Yamamoto, Fabian Eisenstein, Chien-Chi Hsiao, Masaharu Kurosawa, Karl Gademann, Martin Pilhofer, Nobuhiko Nomura, Leo Eberl
Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00492-w
|Nature Communications 8/1||2019-09-04|
Chiara Rapisarda, Yassine Cherrak, Romain Kooger, Victoria Schmidt, Riccardo Pellarin, Laureen Logger, Eric Cascales, Martin Pilhofer, Eric Durand, RÃ©mi Fronzes
In situ and highâ€resolution cryoâ€EM structure of a bacterial type VI secretion system membrane complex
published pages: e100886, ISSN: 0261-4189, DOI: 10.15252/embj.2018100886
|The EMBO Journal 38/10||2019-09-04|
Piotr Szwedziak, Martin Pilhofer
Bidirectional contraction of a type six secretion system
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09603-1
|Nature Communications 10/1||2019-09-04|
JoÃ£o M. Medeiros, DÃ©sirÃ©e BÃ¶ck, Gregor L. Weiss, Romain Kooger, Roger A. Wepf, Martin Pilhofer
Robust workflow and instrumentation for cryo-focused ion beam milling of samples for electron cryotomography
published pages: 1-11, ISSN: 0304-3991, DOI: 10.1016/j.ultramic.2018.04.002
DÃ©sirÃ©e BÃ¶ck, JoÃ£o M. Medeiros, Han-Fei Tsao, Thomas Penz, Gregor L. Weiss, Karin Aistleitner, Matthias Horn, Martin Pilhofer
In situ architecture, function, and evolution of a contractile injection system
published pages: 713-717, ISSN: 0036-8075, DOI: 10.1126/science.aan7904
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