YEASTMEMORY SIGNED
Memory in biological regulatory circuits
Total Cost €
0EC-Contrib. €
0Partnership
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0YEASTMEMORY project word cloud
Explore the words cloud of the YEASTMEMORY project. It provides you a very rough idea of what is the project "YEASTMEMORY" about.
Project "YEASTMEMORY" data sheet
The following table provides information about the project.
| Coordinator |
VIB VZW
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Project website | https://www.kuleuven.be/verstrepen/en/publications |
| Total cost | 1˙959˙844 € |
| EC max contribution | 1˙959˙844 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2021-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | VIB VZW | BE (ZWIJNAARDE - GENT) | coordinator | 1˙959˙844.00 |
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Project objective
The emergence of intelligence –the ability to remember and analyze data to make decisions– was a milestone in evolution. Intelligence and memory are usually associated with plastic neuronal connections in higher organisms. However, new discoveries hint that a rudimentary form of intelligence is rooted in networks that regulate gene expression in a wide range of organisms, including bacteria and yeasts. Specifically, we and others have shown that microbes show plastic behavioral responses to past experiences, such as previously available nutrients or stresses. This implies that information about the past is somehow retained and passed to next generations, where it influences cellular regulation.
The goal of this project is to use a simple eukaryotic regulatory circuit as a model to obtain a comprehensive picture of the different genes and molecular mechanisms underlying history-dependence (hysteresis) in cellular regulation. Specifically, we will study maltose (MAL) regulation in budding yeast, because this signaling pathway serves as a model for gene regulation circuits in other organisms, including humans. We will use a combination of genetic screens, live-cell microscopy in custom-built microfluidic devices, and mathematical modeling to pursue four aims:
1. To provide a comprehensive quantitative analysis of hysteresis in MAL regulation 2. To unravel the molecular mechanisms contributing to hysteresis 3. To unravel the epigenetic mechanisms allowing hysteresis to extend over several generations 4. To characterize the ecological relevance of hysteresis
This project will establish an innovative model for hysteresis and generate a genome-wide, systems-level view of how past influences can be stored in regulatory cascades to influence cellular decision-making. The results will contribute to a paradigm shift in our view of biological regulation and memory, with possible applications in fields as diverse as industrial microbiology, synthetic biology and medicine.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Brigida Gallone, Jan Steensels, Stijn Mertens, Maria C. Dzialo, Jonathan L. Gordon, Ruben Wauters, Florian A. Theßeling, Francesca Bellinazzo, Veerle Saels, Beatriz Herrera-Malaver, Troels Prahl, Christopher White, Mathias Hutzler, Franz Meußdoerffer, Philippe Malcorps, Ben Souffriau, Luk Daenen, Guy Baele, Steven Maere, Kevin J. Verstrepen Interspecific hybridization facilitates niche adaptation in beer yeast published pages: 1562-1575, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0997-9 |
Nature Ecology & Evolution 3/11 | 2019-11-12 |
| 2019 |
Florian A. Thesseling, Peter W. Bircham, Stijn Mertens, Karin Voordeckers, Kevin J. Verstrepen A Handsâ€On Guide to Brewing and Analyzing Beer in the Laboratory published pages: , ISSN: 1934-8525, DOI: 10.1002/cpmc.91 |
Current Protocols in Microbiology 54/1 | 2019-11-12 |
| 2018 |
Bram Cerulus, Abbas Jariani, Gemma Perez-Samper, Lieselotte Vermeersch, Julian MJ Pietsch, Matthew M Crane, Aaron M New, Brigida Gallone, Miguel Roncoroni, Maria C Dzialo, Sander K Govers, Jhana O Hendrickx, Eva Galle, Maarten Coomans, Pieter Berden, Sara Verbandt, Peter S Swain, Kevin J Verstrepen Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.39234 |
eLife 7 | 2019-06-18 |
| 2018 |
Gemma Perez-Samper, Bram Cerulus, Abbas Jariani, Lieselotte Vermeersch, Nuria Barrajón Simancas, Markus M. M. Bisschops, Joost van den Brink, Daniel Solis-Escalante, Brigida Gallone, Dries De Maeyer, Elise van Bael, Tom Wenseleers, Jan Michiels, Kathleen Marchal, Pascale Daran-Lapujade, Kevin J. Verstrepen The Crabtree Effect Shapes the Saccharomyces cerevisiae Lag Phase during the Switch between Different Carbon Sources published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01331-18 |
mBio 9/5 | 2019-06-18 |
| 2019 |
Lieselotte Vermeersch, Gemma Perez-Samper, Bram Cerulus, Abbas Jariani, Brigida Gallone, Karin Voordeckers, Jan Steensels, Kevin J. Verstrepen On the duration of the microbial lag phase published pages: 721-727, ISSN: 0172-8083, DOI: 10.1007/s00294-019-00938-2 |
Current Genetics 65/3 | 2019-06-18 |
| 2019 |
Yannick Vervoort, Rodrigo Sergio Wiederkehr, Michiel Smets, Maarten Fauvart, Tim Stakenborg, Gabrielle Woronoff, Liesbet Lagae, Kevin J. Verstrepen Development and validation of a glass-silicon microdroplet-based system to measure sulfite concentrations in beverages published pages: 1127-1134, ISSN: 1618-2642, DOI: 10.1007/s00216-018-1516-6 |
Analytical and Bioanalytical Chemistry 411/6 | 2019-06-18 |
| 2016 |
Brigida Gallone, Jan Steensels, Troels Prahl, Leah Soriaga, Veerle Saels, Beatriz Herrera-Malaver, Adriaan Merlevede, Miguel Roncoroni, Karin Voordeckers, Loren Miraglia, Clotilde Teiling, Brian Steffy, Maryann Taylor, Ariel Schwartz, Toby Richardson, Christopher White, Guy Baele, Steven Maere, Kevin J. Verstrepen Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts published pages: 1397-1410.e16, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.08.020 |
Cell 166/6 | 2019-06-06 |
| 2016 |
Bram Cerulus, Aaron M. New, Ksenia Pougach, Kevin J. Verstrepen Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness published pages: 1138-1147, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.03.010 |
Current Biology 26/9 | 2019-06-06 |
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