Explore the words cloud of the YEASTMEMORY project. It provides you a very rough idea of what is the project "YEASTMEMORY" about.
The following table provides information about the project.
|Coordinator Country||Belgium [BE]|
|Total cost||1˙959˙844 €|
|EC max contribution||1˙959˙844 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2021-09-30|
Take a look of project's partnership.
|1||VIB VZW||BE (ZWIJNAARDE - GENT)||coordinator||1˙959˙844.00|
The emergence of intelligence –the ability to remember and analyze data to make decisions– was a milestone in evolution. Intelligence and memory are usually associated with plastic neuronal connections in higher organisms. However, new discoveries hint that a rudimentary form of intelligence is rooted in networks that regulate gene expression in a wide range of organisms, including bacteria and yeasts. Specifically, we and others have shown that microbes show plastic behavioral responses to past experiences, such as previously available nutrients or stresses. This implies that information about the past is somehow retained and passed to next generations, where it influences cellular regulation.
The goal of this project is to use a simple eukaryotic regulatory circuit as a model to obtain a comprehensive picture of the different genes and molecular mechanisms underlying history-dependence (hysteresis) in cellular regulation. Specifically, we will study maltose (MAL) regulation in budding yeast, because this signaling pathway serves as a model for gene regulation circuits in other organisms, including humans. We will use a combination of genetic screens, live-cell microscopy in custom-built microfluidic devices, and mathematical modeling to pursue four aims:
1. To provide a comprehensive quantitative analysis of hysteresis in MAL regulation 2. To unravel the molecular mechanisms contributing to hysteresis 3. To unravel the epigenetic mechanisms allowing hysteresis to extend over several generations 4. To characterize the ecological relevance of hysteresis
This project will establish an innovative model for hysteresis and generate a genome-wide, systems-level view of how past influences can be stored in regulatory cascades to influence cellular decision-making. The results will contribute to a paradigm shift in our view of biological regulation and memory, with possible applications in fields as diverse as industrial microbiology, synthetic biology and medicine.
|year||authors and title||journal||last update|
Brigida Gallone, Jan Steensels, Stijn Mertens, Maria C. Dzialo, Jonathan L. Gordon, Ruben Wauters, Florian A. TheÃŸeling, Francesca Bellinazzo, Veerle Saels, Beatriz Herrera-Malaver, Troels Prahl, Christopher White, Mathias Hutzler, Franz MeuÃŸdoerffer, Philippe Malcorps, Ben Souffriau, Luk Daenen, Guy Baele, Steven Maere, Kevin J. Verstrepen
Interspecific hybridization facilitates niche adaptation in beer yeast
published pages: 1562-1575, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0997-9
|Nature Ecology & Evolution 3/11||2019-11-12|
Florian A. Thesseling, Peter W. Bircham, Stijn Mertens, Karin Voordeckers, Kevin J. Verstrepen
A Handsâ€On Guide to Brewing and Analyzing Beer in the Laboratory
published pages: , ISSN: 1934-8525, DOI: 10.1002/cpmc.91
|Current Protocols in Microbiology 54/1||2019-11-12|
Bram Cerulus, Abbas Jariani, Gemma Perez-Samper, Lieselotte Vermeersch, Julian MJ Pietsch, Matthew M Crane, Aaron M New, Brigida Gallone, Miguel Roncoroni, Maria C Dzialo, Sander K Govers, Jhana O Hendrickx, Eva Galle, Maarten Coomans, Pieter Berden, Sara Verbandt, Peter S Swain, Kevin J Verstrepen
Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.39234
Gemma Perez-Samper, Bram Cerulus, Abbas Jariani, Lieselotte Vermeersch, Nuria BarrajÃ³n Simancas, Markus M. M. Bisschops, Joost van den Brink, Daniel Solis-Escalante, Brigida Gallone, Dries De Maeyer, Elise van Bael, Tom Wenseleers, Jan Michiels, Kathleen Marchal, Pascale Daran-Lapujade, Kevin J. Verstrepen
The Crabtree Effect Shapes the Saccharomyces cerevisiae Lag Phase during the Switch between Different Carbon Sources
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01331-18
Lieselotte Vermeersch, Gemma Perez-Samper, Bram Cerulus, Abbas Jariani, Brigida Gallone, Karin Voordeckers, Jan Steensels, Kevin J. Verstrepen
On the duration of the microbial lag phase
published pages: 721-727, ISSN: 0172-8083, DOI: 10.1007/s00294-019-00938-2
|Current Genetics 65/3||2019-06-18|
Yannick Vervoort, Rodrigo Sergio Wiederkehr, Michiel Smets, Maarten Fauvart, Tim Stakenborg, Gabrielle Woronoff, Liesbet Lagae, Kevin J. Verstrepen
Development and validation of a glass-silicon microdroplet-based system to measure sulfite concentrations in beverages
published pages: 1127-1134, ISSN: 1618-2642, DOI: 10.1007/s00216-018-1516-6
|Analytical and Bioanalytical Chemistry 411/6||2019-06-18|
Brigida Gallone, Jan Steensels, Troels Prahl, Leah Soriaga, Veerle Saels, Beatriz Herrera-Malaver, Adriaan Merlevede, Miguel Roncoroni, Karin Voordeckers, Loren Miraglia, Clotilde Teiling, Brian Steffy, Maryann Taylor, Ariel Schwartz, Toby Richardson, Christopher White, Guy Baele, Steven Maere, Kevin J. Verstrepen
Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts
published pages: 1397-1410.e16, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.08.020
Bram Cerulus, AaronÂ M. New, Ksenia Pougach, KevinÂ J. Verstrepen
Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness
published pages: 1138-1147, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.03.010
|Current Biology 26/9||2019-06-06|
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