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YEASTMEMORY SIGNED

Memory in biological regulatory circuits

Total Cost €

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EC-Contrib. €

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Partnership

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 YEASTMEMORY project word cloud

Explore the words cloud of the YEASTMEMORY project. It provides you a very rough idea of what is the project "YEASTMEMORY" about.

generate    intelligence    evolution    gene    nutrients    medicine    humans    previously    budding    generations    signaling    rudimentary    decision    custom    yeast    paradigm    connections    yeasts    circuits    influence    bacteria    milestone    microfluidic    microbiology    regulatory    industrial    data    experiences    biological    decisions    mal    genes    form    model    neuronal    expression    genetic    circuit    dependence    plastic    serves    epigenetic    regulate    cascades    stored    synthetic    microbes    genome    stresses    unravel    cell    regulation    memory    biology    passed    behavioral    influences    picture    combination    usually    shift    history    analyze    live    networks    microscopy    cellular    view    screens    eukaryotic    maltose    hint    obtain    quantitative    remember    shown    diverse    ecological    pursue    emergence    rooted    molecular    innovative    mechanisms    retained    relevance    discoveries    somehow    underlying    hysteresis    implies    mathematical    organisms    extend    modeling   

Project "YEASTMEMORY" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://www.kuleuven.be/verstrepen/en/publications
 Total cost 1˙959˙844 €
 EC max contribution 1˙959˙844 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 1˙959˙844.00

Map

 Project objective

The emergence of intelligence –the ability to remember and analyze data to make decisions– was a milestone in evolution. Intelligence and memory are usually associated with plastic neuronal connections in higher organisms. However, new discoveries hint that a rudimentary form of intelligence is rooted in networks that regulate gene expression in a wide range of organisms, including bacteria and yeasts. Specifically, we and others have shown that microbes show plastic behavioral responses to past experiences, such as previously available nutrients or stresses. This implies that information about the past is somehow retained and passed to next generations, where it influences cellular regulation.

The goal of this project is to use a simple eukaryotic regulatory circuit as a model to obtain a comprehensive picture of the different genes and molecular mechanisms underlying history-dependence (hysteresis) in cellular regulation. Specifically, we will study maltose (MAL) regulation in budding yeast, because this signaling pathway serves as a model for gene regulation circuits in other organisms, including humans. We will use a combination of genetic screens, live-cell microscopy in custom-built microfluidic devices, and mathematical modeling to pursue four aims:

1. To provide a comprehensive quantitative analysis of hysteresis in MAL regulation 2. To unravel the molecular mechanisms contributing to hysteresis 3. To unravel the epigenetic mechanisms allowing hysteresis to extend over several generations 4. To characterize the ecological relevance of hysteresis

This project will establish an innovative model for hysteresis and generate a genome-wide, systems-level view of how past influences can be stored in regulatory cascades to influence cellular decision-making. The results will contribute to a paradigm shift in our view of biological regulation and memory, with possible applications in fields as diverse as industrial microbiology, synthetic biology and medicine.

 Publications

year authors and title journal last update
List of publications.
2019 Brigida Gallone, Jan Steensels, Stijn Mertens, Maria C. Dzialo, Jonathan L. Gordon, Ruben Wauters, Florian A. Theßeling, Francesca Bellinazzo, Veerle Saels, Beatriz Herrera-Malaver, Troels Prahl, Christopher White, Mathias Hutzler, Franz Meußdoerffer, Philippe Malcorps, Ben Souffriau, Luk Daenen, Guy Baele, Steven Maere, Kevin J. Verstrepen
Interspecific hybridization facilitates niche adaptation in beer yeast
published pages: 1562-1575, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0997-9
Nature Ecology & Evolution 3/11 2019-11-12
2019 Florian A. Thesseling, Peter W. Bircham, Stijn Mertens, Karin Voordeckers, Kevin J. Verstrepen
A Hands‐On Guide to Brewing and Analyzing Beer in the Laboratory
published pages: , ISSN: 1934-8525, DOI: 10.1002/cpmc.91
Current Protocols in Microbiology 54/1 2019-11-12
2018 Bram Cerulus, Abbas Jariani, Gemma Perez-Samper, Lieselotte Vermeersch, Julian MJ Pietsch, Matthew M Crane, Aaron M New, Brigida Gallone, Miguel Roncoroni, Maria C Dzialo, Sander K Govers, Jhana O Hendrickx, Eva Galle, Maarten Coomans, Pieter Berden, Sara Verbandt, Peter S Swain, Kevin J Verstrepen
Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.39234
eLife 7 2019-06-18
2018 Gemma Perez-Samper, Bram Cerulus, Abbas Jariani, Lieselotte Vermeersch, Nuria Barrajón Simancas, Markus M. M. Bisschops, Joost van den Brink, Daniel Solis-Escalante, Brigida Gallone, Dries De Maeyer, Elise van Bael, Tom Wenseleers, Jan Michiels, Kathleen Marchal, Pascale Daran-Lapujade, Kevin J. Verstrepen
The Crabtree Effect Shapes the Saccharomyces cerevisiae Lag Phase during the Switch between Different Carbon Sources
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.01331-18
mBio 9/5 2019-06-18
2019 Lieselotte Vermeersch, Gemma Perez-Samper, Bram Cerulus, Abbas Jariani, Brigida Gallone, Karin Voordeckers, Jan Steensels, Kevin J. Verstrepen
On the duration of the microbial lag phase
published pages: 721-727, ISSN: 0172-8083, DOI: 10.1007/s00294-019-00938-2
Current Genetics 65/3 2019-06-18
2019 Yannick Vervoort, Rodrigo Sergio Wiederkehr, Michiel Smets, Maarten Fauvart, Tim Stakenborg, Gabrielle Woronoff, Liesbet Lagae, Kevin J. Verstrepen
Development and validation of a glass-silicon microdroplet-based system to measure sulfite concentrations in beverages
published pages: 1127-1134, ISSN: 1618-2642, DOI: 10.1007/s00216-018-1516-6
Analytical and Bioanalytical Chemistry 411/6 2019-06-18
2016 Brigida Gallone, Jan Steensels, Troels Prahl, Leah Soriaga, Veerle Saels, Beatriz Herrera-Malaver, Adriaan Merlevede, Miguel Roncoroni, Karin Voordeckers, Loren Miraglia, Clotilde Teiling, Brian Steffy, Maryann Taylor, Ariel Schwartz, Toby Richardson, Christopher White, Guy Baele, Steven Maere, Kevin J. Verstrepen
Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts
published pages: 1397-1410.e16, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.08.020
Cell 166/6 2019-06-06
2016 Bram Cerulus, Aaron M. New, Ksenia Pougach, Kevin J. Verstrepen
Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness
published pages: 1138-1147, ISSN: 0960-9822, DOI: 10.1016/j.cub.2016.03.010
Current Biology 26/9 2019-06-06

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