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SA-VOIR SIGNED

Assessing the feasibility of MT-011, a first-in-class drug to treat glaucoma and other neurodegenerative diseases via a breakthrough mechanism-of-action

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SA-VOIR project word cloud

Explore the words cloud of the SA-VOIR project. It provides you a very rough idea of what is the project "SA-VOIR" about.

inhibiting    payments    pfizer    clinical    voir    parkinson    neurodegenerative    alzheimer    vash    hyperactivated    deterioration    documents    implicated    biotechnological    inherently    outline    attract    continued    optimization    blindness    irreverisble    commercialize    40m    drug    biochemical    patients    critical    enzyme    applicable    nanomolar    people    form    stage    proprietary    total    dysregulation    small    trials    investment    guide    million    black    deal    peripheral    30    disorder    seeing    subtype    broad    inhibits    indicated    plan    santen    normal    applicability    size    diagnosed    followed    elucidated    newly    mt    upfront    tunnel    business    pharmaceutical    manner    house    components    licensing    eye    diseases    neurogenerative    tension    milestone    assay    act    pharmaceuticals    candidate    sa    011    inhibit    strengthen    imminent    receive    assets    start    aside    risked    prominent    causes    halt    vision    report    companies    treatments    affinity    family    drugs    glaucoma    de    world    molecule   

Project "SA-VOIR" data sheet

The following table provides information about the project.

Coordinator
MT ACT 

Organization address
address: 66 RUE DU CLAOUS
city: CAZILHAC
postcode: 34190
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3. (PRIORITY 'Societal challenges)
2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs)
3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
 Code Call H2020-SMEInst-2018-2020-1
 Funding Scheme SME-1
 Starting year 2019
 Duration (year-month-day) from 2019-12-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MT ACT FR (CAZILHAC) coordinator 50˙000.00

Map

 Project objective

Glaucoma is the world's leading cause of irreverisble blindness, affecting 20 million people in Europe and the US. Known as the Alzheimer’s of the eye, glaucoma is a neurodegenerative disorder that causes deterioration in peripheral vision. Affected patients report ‘seeing through a black tunnel’. Treatments to halt vision loss are available however, they are only applicable for the ‘high tension glaucoma’ subtype. For those diagnosed with ‘normal tension', which comprises over 30% of glaucoma patients, no treatments are available, and vision loss is imminent. New drugs that inhibit VASH, a newly elucidated enzyme that is hyperactivated in many neurogenerative diseases, have potential to address this need.

We at MT-act are a biotechnological start-up who have identified a family of VASH-inhibiting small molecule drugs. Using an in-house proprietary biochemical assay followed by lead optimization, we have identified MT-011, which inhibits VASH with nanomolar affinity, as our lead candidate. Aside from glaucoma, VASH dysregulation is also implicated in other prominent neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Our assets therefore have an inherently broad applicability.

We aim to develop MT-011 up to the stage of Phase 1 clinical trials, upon which we aim to commercialize the drug via a licensing deal with a pharmaceutical partner. We will then receive upfront and milestone payments with a estimated total deal size of €40M. We are currently in discussion with world-leading pharmaceutical companies Pfizer and Santen Pharmaceuticals, who have already indicated interest in our drugs.

In SA-VOIR, we aim to strengthen the business case for MT-011 and to outline a detailed technical plan for its continued development. These documents will not only guide us in developing MT-011 towards Phase 1 trials in an effective and de-risked manner, it will also form critical components of a business plan that we will use to attract further investment.

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The information about "SA-VOIR" are provided by the European Opendata Portal: CORDIS opendata.

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