Opendata, web and dolomites

THaCH SIGNED

The effects of hypercholesterolemia on tendon health (Tendon Health and CHolesterol)

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 THaCH project word cloud

Explore the words cloud of the THaCH project. It provides you a very rough idea of what is the project "THaCH" about.

muscle    tendons    cholesterol    readily    total    explored    function    cell    space    oxldl    healing    fascicle    area    diseases    hypercholesterolemia    expertise    occupational    union    extension    reversibility    extravascular    data    underlying    extracellular    demonstrated    pathophysiology    health    matrix    biomechanical    rehabilitation    link    linking    external    mechanism    tendon    examined    medicine    gene    putative    ldl    ifm    mechanisms    entrapped    poor    mechanics    clinical    researched    elevated    tissue    becomes    socio    accumulates    expression    glycosaminoglycans    interactions    groups    life    hypothesis    altering    suitable    association    models    gag    quality    hypotheses    economic    strategies    orthopedic    normal    host    institutes    musculoskeletal    unknown    employs    probe    disability    individuals    interfascicular    reduce    impairing    biology    leave    collagen    implications    sciences    circulation    structure    inhibiting    services    sliding    oxidized    negatively    demonstrates    preventative    laboratory    impacts    disorders    accumulate    accumulation    phenotype   

Project "THaCH" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 237˙349 €
 EC max contribution 237˙349 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2022-03-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 237˙349.00
2    UNIVERSITY OF BRITISH COLUMBIA CA (VANCOUVER) partner 0.00

Map

 Project objective

Musculoskeletal disorders, particularly to the muscle-tendon unit, are a major cause of occupational disability in the European Union. The link between high cholesterol and poor tendon function has recently been demonstrated by several groups. However, the underlying pathophysiology of this association remains unknown. Cholesterol is known to leave the circulation and accumulate in extracellular matrix through interactions between LDL and glycosaminoglycans (GAG). Tendons are GAG rich in the interfascicular matrix (IFM: a tendon structure facilitating collagen fascicle sliding and extension). One putative mechanism by which high cholesterol may impact tendon function is an accumulation of cholesterol and LDL in the IFM, impairing fascicle sliding and extension. In addition, LDL readily becomes oxidized (oxLDL) when entrapped in the extravascular space, and recent data demonstrates this negatively impacts tendon cell phenotype, altering normal gene expression. This proposal aims to enhance our understanding of hypercholesterolemia on tendon health; a highly under-researched area of significant clinical importance. It employs expertise in tissue mechanics and tendon cell biology available at the host and external institutes to probe the mechanisms linking high cholesterol and tendon pathophysiology. The underlying hypotheses are that in individuals with elevated total cholesterol and/or LDL, cholesterol accumulates with LDL in GAG-rich areas of tendon like the IFM, inhibiting tendon biomechanical function. This hypothesis will be explored using suitable laboratory models, allowing the reversibility of these changes and their impact on tendon adaptation and healing to be examined. The findings will have immediate implications for orthopedic sciences, preventative medicine and rehabilitation services, strategies and technology. They have the potential to improve quality of life and reduce the socio-economic costs associated with orthopedic and musculoskeletal diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "THACH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "THACH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MultiSeaSpace (2019)

Developing a unified spatial modelling strategy that accounts for interactions between species at different marine trophic levels, and different types of survey data.

Read More  

AMPLE (2019)

A Study of the Notion of Ampleness in Model Theory and Tits Buildings

Read More  

INSPiRE (2018)

The Influence of Information Search on Preference Formation and Choice

Read More