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THaCH SIGNED

The effects of hypercholesterolemia on tendon health (Tendon Health and CHolesterol)

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 THaCH project word cloud

Explore the words cloud of the THaCH project. It provides you a very rough idea of what is the project "THaCH" about.

life    tendons    tendon    accumulation    interfascicular    explored    linking    laboratory    biomechanical    medicine    data    function    reduce    biology    rehabilitation    interactions    strategies    expression    orthopedic    preventative    elevated    employs    hypercholesterolemia    impairing    poor    demonstrated    extracellular    association    demonstrates    diseases    putative    disorders    mechanics    mechanisms    individuals    researched    union    institutes    space    probe    sliding    groups    mechanism    negatively    economic    host    cholesterol    underlying    circulation    extension    oxidized    hypotheses    readily    unknown    external    cell    oxldl    ldl    inhibiting    collagen    matrix    implications    gene    expertise    area    fascicle    sciences    leave    ifm    phenotype    extravascular    occupational    glycosaminoglycans    structure    accumulate    becomes    quality    health    healing    socio    reversibility    examined    suitable    link    pathophysiology    altering    services    hypothesis    muscle    accumulates    musculoskeletal    gag    clinical    tissue    total    models    normal    disability    impacts    entrapped   

Project "THaCH" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 237˙349 €
 EC max contribution 237˙349 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2022-03-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 237˙349.00
2    UNIVERSITY OF BRITISH COLUMBIA CA (VANCOUVER) partner 0.00

Map

 Project objective

Musculoskeletal disorders, particularly to the muscle-tendon unit, are a major cause of occupational disability in the European Union. The link between high cholesterol and poor tendon function has recently been demonstrated by several groups. However, the underlying pathophysiology of this association remains unknown. Cholesterol is known to leave the circulation and accumulate in extracellular matrix through interactions between LDL and glycosaminoglycans (GAG). Tendons are GAG rich in the interfascicular matrix (IFM: a tendon structure facilitating collagen fascicle sliding and extension). One putative mechanism by which high cholesterol may impact tendon function is an accumulation of cholesterol and LDL in the IFM, impairing fascicle sliding and extension. In addition, LDL readily becomes oxidized (oxLDL) when entrapped in the extravascular space, and recent data demonstrates this negatively impacts tendon cell phenotype, altering normal gene expression. This proposal aims to enhance our understanding of hypercholesterolemia on tendon health; a highly under-researched area of significant clinical importance. It employs expertise in tissue mechanics and tendon cell biology available at the host and external institutes to probe the mechanisms linking high cholesterol and tendon pathophysiology. The underlying hypotheses are that in individuals with elevated total cholesterol and/or LDL, cholesterol accumulates with LDL in GAG-rich areas of tendon like the IFM, inhibiting tendon biomechanical function. This hypothesis will be explored using suitable laboratory models, allowing the reversibility of these changes and their impact on tendon adaptation and healing to be examined. The findings will have immediate implications for orthopedic sciences, preventative medicine and rehabilitation services, strategies and technology. They have the potential to improve quality of life and reduce the socio-economic costs associated with orthopedic and musculoskeletal diseases.

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The information about "THACH" are provided by the European Opendata Portal: CORDIS opendata.

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