Opendata, web and dolomites

DendritesInVivo SIGNED

Prediction and validation of in vivo dendritic processing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DendritesInVivo project word cloud

Explore the words cloud of the DendritesInVivo project. It provides you a very rough idea of what is the project "DendritesInVivo" about.

algorithmic    answer    tree    code    neurons    critical    confer    decades    formulate    dual    obstacle    gap    glutamate    fundamental    primary    statistics    strategies    tuned    extracted    model    salient    anticipate    dendrites    validate    presented    discover    biological    discriminate    unclear    biophysical    actually    unknown    output    employed    vivo    encoding    remarkable    elaborate    cortical    mice    function    insights    experiments    axon    dendritic    living    repertoire    presynaptic    computation    questions    elucidated    construct    predict    action    morphology    imaging    learns    extension    theory    optimal    suite    synergy    colour    awake    principles    experiment    photon    host    neural    behaving    decoding    synaptic    shaped    lab    integration    operations    theoretical    combining    computational    stimulus    patterns    dynamics    cell    vast    network    neuron    scheme    predictions    brain    visual    input    release    yield    spatiotemporal    largely    single    mechanisms    expertise    postsynaptic    calcium    nonlinear    transduction    cortex   

Project "DendritesInVivo" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 212˙933.00

Map

 Project objective

Integration of synaptic input by single neurons is fundamental to computation in the brain. The output of every cell within a network is shaped by the elaborate morphology of its dendritic tree, and a suite of biophysical mechanisms that confer nonlinear processing capabilities. Over past decades, a remarkable synergy between theory and experiment has elucidated key strategies by which single-cell processing could thus enhance the neural code. However, a critical gap in current understanding remains: which operations from the vast dendritic repertoire are actually employed in vivo? One major obstacle to addressing this problem is that the statistics of in vivo input patterns are largely unknown. Thus, it is unclear how salient information is presented to the dendrites of a neuron, and by extension, what mechanisms are used for its transduction to action potential output at the axon.

I aim to answer these questions by combining my expertise with that of the host lab to formulate theoretical predictions and then validate them with in vivo experiments. Specifically, I will construct a computational model of a cortical neuron that learns to discriminate synaptic input patterns, and use it to discover the optimal scheme for encoding and decoding information. I will thus predict the spatiotemporal patterns of synaptic input to stimulus-tuned neurons, and the biophysical mechanisms through which this information can be extracted. I will then test these predictions in primary visual cortex of awake behaving mice through two-photon dual-colour imaging of presynaptic glutamate release and postsynaptic calcium dynamics. By relating the algorithmic and biological function of neurons in the living brain, I anticipate this project will yield important insights into general principles of neural computation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DENDRITESINVIVO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DENDRITESINVIVO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

CORRELATION (2020)

Characterization and prediction of service-level traffic for future sliced mobile network

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More