Opendata, web and dolomites

DendritesInVivo SIGNED

Prediction and validation of in vivo dendritic processing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DendritesInVivo project word cloud

Explore the words cloud of the DendritesInVivo project. It provides you a very rough idea of what is the project "DendritesInVivo" about.

cell    unclear    answer    synaptic    postsynaptic    discriminate    scheme    mice    single    dual    presented    decoding    employed    visual    algorithmic    neurons    suite    presynaptic    integration    remarkable    combining    colour    dynamics    vast    predictions    computational    dendrites    decades    encoding    shaped    theory    nonlinear    biophysical    awake    biological    learns    validate    cortex    dendritic    release    predict    synergy    actually    elaborate    patterns    optimal    brain    critical    vivo    computation    neural    gap    obstacle    largely    experiment    photon    action    output    tree    tuned    cortical    code    elucidated    theoretical    host    questions    expertise    function    fundamental    calcium    insights    discover    unknown    spatiotemporal    axon    imaging    living    transduction    lab    primary    network    construct    stimulus    experiments    operations    salient    glutamate    strategies    principles    mechanisms    behaving    input    confer    extension    model    formulate    repertoire    extracted    morphology    neuron    yield    anticipate    statistics   

Project "DendritesInVivo" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 212˙933.00

Map

 Project objective

Integration of synaptic input by single neurons is fundamental to computation in the brain. The output of every cell within a network is shaped by the elaborate morphology of its dendritic tree, and a suite of biophysical mechanisms that confer nonlinear processing capabilities. Over past decades, a remarkable synergy between theory and experiment has elucidated key strategies by which single-cell processing could thus enhance the neural code. However, a critical gap in current understanding remains: which operations from the vast dendritic repertoire are actually employed in vivo? One major obstacle to addressing this problem is that the statistics of in vivo input patterns are largely unknown. Thus, it is unclear how salient information is presented to the dendrites of a neuron, and by extension, what mechanisms are used for its transduction to action potential output at the axon.

I aim to answer these questions by combining my expertise with that of the host lab to formulate theoretical predictions and then validate them with in vivo experiments. Specifically, I will construct a computational model of a cortical neuron that learns to discriminate synaptic input patterns, and use it to discover the optimal scheme for encoding and decoding information. I will thus predict the spatiotemporal patterns of synaptic input to stimulus-tuned neurons, and the biophysical mechanisms through which this information can be extracted. I will then test these predictions in primary visual cortex of awake behaving mice through two-photon dual-colour imaging of presynaptic glutamate release and postsynaptic calcium dynamics. By relating the algorithmic and biological function of neurons in the living brain, I anticipate this project will yield important insights into general principles of neural computation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DENDRITESINVIVO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DENDRITESINVIVO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

lanloss (2020)

Landscapes of Loss: Mapping the Affective Experience of Deforestation Among Diverse Social Groups in the South American Chaco

Read More  

DEMOS (2019)

Disfluencies and Eye MOvements during Speech: what can they reveal about language production?

Read More