Opendata, web and dolomites

DendritesInVivo SIGNED

Prediction and validation of in vivo dendritic processing

Total Cost €


EC-Contrib. €






 DendritesInVivo project word cloud

Explore the words cloud of the DendritesInVivo project. It provides you a very rough idea of what is the project "DendritesInVivo" about.

shaped    experiments    validate    dendritic    insights    employed    primary    extension    unknown    confer    theory    output    cell    synaptic    largely    operations    optimal    suite    axon    visual    salient    neuron    encoding    photon    neurons    mice    awake    model    elucidated    decoding    algorithmic    decades    cortical    combining    host    glutamate    learns    critical    patterns    lab    postsynaptic    discover    gap    calcium    fundamental    repertoire    principles    mechanisms    biophysical    unclear    network    experiment    discriminate    tuned    extracted    function    integration    spatiotemporal    neural    tree    vast    remarkable    brain    cortex    single    dendrites    input    morphology    strategies    release    predict    obstacle    living    formulate    predictions    elaborate    presynaptic    transduction    construct    stimulus    expertise    questions    scheme    dual    yield    anticipate    statistics    dynamics    theoretical    behaving    vivo    colour    biological    imaging    presented    actually    synergy    computation    computational    answer    nonlinear    action    code   

Project "DendritesInVivo" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 212˙933.00


 Project objective

Integration of synaptic input by single neurons is fundamental to computation in the brain. The output of every cell within a network is shaped by the elaborate morphology of its dendritic tree, and a suite of biophysical mechanisms that confer nonlinear processing capabilities. Over past decades, a remarkable synergy between theory and experiment has elucidated key strategies by which single-cell processing could thus enhance the neural code. However, a critical gap in current understanding remains: which operations from the vast dendritic repertoire are actually employed in vivo? One major obstacle to addressing this problem is that the statistics of in vivo input patterns are largely unknown. Thus, it is unclear how salient information is presented to the dendrites of a neuron, and by extension, what mechanisms are used for its transduction to action potential output at the axon.

I aim to answer these questions by combining my expertise with that of the host lab to formulate theoretical predictions and then validate them with in vivo experiments. Specifically, I will construct a computational model of a cortical neuron that learns to discriminate synaptic input patterns, and use it to discover the optimal scheme for encoding and decoding information. I will thus predict the spatiotemporal patterns of synaptic input to stimulus-tuned neurons, and the biophysical mechanisms through which this information can be extracted. I will then test these predictions in primary visual cortex of awake behaving mice through two-photon dual-colour imaging of presynaptic glutamate release and postsynaptic calcium dynamics. By relating the algorithmic and biological function of neurons in the living brain, I anticipate this project will yield important insights into general principles of neural computation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DENDRITESINVIVO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DENDRITESINVIVO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

RegARcis (2020)

Role of the SWI/SNF complex in the Androgen Receptor cistrome regulation

Read More  

CATSO (2020)

New Catalytic Reactions using Sulfur Dioxide

Read More  

IQubitNet (2019)

Integrated multi-qubit devices for scalable quantum networks

Read More