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iRELaTE SIGNED

Immune Response and Social Cognition in Schizophrenia

Total Cost €

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EC-Contrib. €

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Partnership

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Project "iRELaTE" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙477˙622 €
 EC max contribution 1˙477˙622 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙477˙622.00

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 Project objective

Schizophrenia, affecting 0.5-1% of the population, is ranked by the World Health Organisation as more disabling than paraplegia or blindness in 18-34 year olds. Current treatments, developed over 50 years ago, are only partly effective in treating this disability, and new treatments are lacking. To address this treatment impasse, this project aims to develop and test a novel immune based model of deficits in social cognition – the set of mental operations that underlie social interactions (e.g. emotion recognition, theory of mind) and strongly predict social disability in schizophrenia. Based on recent discoveries in schizophrenia genetics, this project asks: (1) are genetic causes of deficits in social cognition mediated by effects on immune function during development and (2) does early social environment moderate these effects? To address these questions, the project has two parts. Part A focuses on neuropsychological and neuroimaging studies of social cognition in patients and healthy adults so as to (1) provide an innovative characterisation of the effects of inflammatory markers (e.g. pro-/anti- inflammatory cytokines) on social cognition, (2) establish whether these markers mediate the effects of recently identified genetic risk loci on schizophrenia, and (3) identify to what extent early social environment (e.g. parental relationships, childhood trauma) moderates this relationship. Part B focuses on behavioural and pharmacological studies in mice to (1) establish the causal effects of early immune challenge and early social environment on social cognition, and (2) test the translational benefits of anti-inflammatory treatment to normalize the resulting deficits. By validating an immune based model of schizophrenia, this project has the potential to move beyond current (dopamine based) treatments, and suggest groundbreaking alternatives for understanding and treating social disability in this and other neurodevelopmental disorders.

 Publications

year authors and title journal last update
List of publications.
2018 G. Donohoe, J. Holland, D. Mothersill, S. McCarthy-Jones, D. Cosgrove, D. Harold, A. Richards, K. Mantripragada, M. J. Owen, M. C. O\'Donovan, M. Gill, A. Corvin, D. W. Morris
Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation
published pages: 1-10, ISSN: 0033-2917, DOI: 10.1017/S0033291717002987
Psychological Medicine 2019-07-08
2017 S Kelly, N Jahanshad, A Zalesky, P Kochunov, I Agartz, C Alloza, O A Andreassen, C Arango, N Banaj, S Bouix, C A Bousman, R M Brouwer, J Bruggemann, J Bustillo, W Cahn, V Calhoun, D Cannon, V Carr, S Catts, J Chen, J-x Chen, X Chen, C Chiapponi, Kl K Cho, V Ciullo, A S Corvin, B Crespo-Facorro, V Cropley, P De Rossi, C M Diaz-Caneja, E W Dickie, S Ehrlich, F-m Fan, J Faskowitz, H Fatouros-Bergman,
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
published pages: , ISSN: 1359-4184, DOI: 10.1038/mp.2017.170
Molecular Psychiatry 2019-07-08
2018 Karolina I. Rokita, Maria R. Dauvermann, Gary Donohoe
Early life experiences and social cognition in major psychiatric disorders: A systematic review
published pages: 123-133, ISSN: 0924-9338, DOI: 10.1016/j.eurpsy.2018.06.006
European Psychiatry 53 2019-05-10
2019 Maria R. Dauvermann, Gary Donohoe
The role of childhood trauma in cognitive performance in schizophrenia and bipolar disorder – A systematic review
published pages: 1-11, ISSN: 2215-0013, DOI: 10.1016/j.scog.2018.11.001
Schizophrenia Research: Cognition 16 2019-05-10
2018 David Mothersill, Rachael Dillon, April Hargreaves, Marco Castorina, Emilia Furey, Andrew J. Fagan, James F. Meaney, Brian Fitzmaurice, Brian Hallahan, Colm McDonald, Til Wykes, Aiden Corvin, Ian H. Robertson, Gary Donohoe
Computerised working memory-based cognitive remediation therapy does not affect Reading the Mind in The Eyes test performance or neural activity during a Facial Emotion Recognition test in psychosis
published pages: 1691-1705, ISSN: 0953-816X, DOI: 10.1111/ejn.13976
European Journal of Neuroscience 48/1 2019-05-10

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