UNICODE SIGNED
Evolution and Impact of Heterochromatin on a Young Drosophila Y chromosome
Total Cost €
0EC-Contrib. €
0Partnership
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Project "UNICODE" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAT WIEN
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Project website | https://molevodevo.univie.ac.at/research/research-qi-zhou/ |
| Total cost | 1˙971˙846 € |
| EC max contribution | 1˙971˙846 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-08-01 to 2021-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAT WIEN | AT (WIEN) | coordinator | 1˙971˙846.00 |
Map
Project objective
The transition from euchromatin to heterochromatin is a fundamental process that particularly reshaped the epigenomic landscape of Y chromosome. Its definitive genomic underpinning and broad functional impact are still unclear, as heterochromatin (e.g., that of human Y) is usually too repetitive to study. I have previously demonstrated that, the young Y (‘neo-Y’) chromosome of Drosophila miranda has just initiated such a transition, thus is a powerful model to unveil the evolution, regulation and functional interaction of heterochromatin. I showed that this neo-Y still harbours over 1800 genes, and only 20-50% of the sequences are transposable elements (TE). Over five years, I aim to: 1) precisely resolve the structure and insertion sites of TEs as a pre-requisite for studying heterochromatin, by combining state-of-art sequencing and bioinformatic techniques. 2) I will reveal the de novo heterochromatin formation triggered by TE insertions or the heterochromatin/euchromatin boundary shifts on the neo-Y, by comparing the binding profiles of histone modification hallmarks and insulator proteins of D. miranda to its sibling species D. pseudoobscura, which lacks the neo-Y. Such epigenomic changes have likely driven the exaptation or innovation of small RNA pathways that govern the TE mobility. 3) I will then identify the responsible small RNAs and their encoding loci, which are expected to have newly emerged or differentially expressed in D. miranda relative to D. pseudoobscura. 4) Finally, I will develop CRISPR/Cas9 in D. miranda to manipulate the expression of TEs encoding such small RNAs on the neo-Y, in order to scrutinize how TE/heterochromatin evolution on the Y would impact the chromatin landscape of the entire host genome. The combined aim of this multidisciplinary project is to generate a framework for understanding the basic mechanisms of how heterochromatin evolves; and open a new avenue toward the discovery of Y chromosome function beyond male determination.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Zhang, Jia-Yu; Zhou, Qi On the regulatory evolution of new genes throughout their life history published pages: , ISSN: 0737-4038, DOI: 10.1101/276667 |
Molecular Biology and Evolution 1 | 2019-10-29 |
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