Explore the words cloud of the HIRESMEMMANIP project. It provides you a very rough idea of what is the project "HIRESMEMMANIP" about.
The following table provides information about the project.
TEL AVIV UNIVERSITY
|Coordinator Country||Israel [IL]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2021-09-30|
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|1||TEL AVIV UNIVERSITY||IL (TEL AVIV)||coordinator||1˙500˙000.00|
Short term memory (STM) is impaired at old age and a host of neuropsychiatric disorders, and has been the focus of a multitude of psychological and theoretical studies. However, the underlying neuronal circuit mechanisms remain elusive, mainly due to the lack of experimental tools: we suggest that rapid manipulations at the neuronal level are required for deciphering underlying mechanisms. We have developed an approach combining large-scale extracellular recordings and high density multi-site/multi-color optical stimulation (“diode-probes”), which enables high resolution closed-loop manipulation of multiple circuit elements in intact, free, behaving rodents. After training mice and rats to perform bridging-free STM-tasks, we will evaluate local circuit mechanisms in hippocampus and prefrontal cortex. Two broad classes of manipulations will be used: First, necessary components and timescales needed for STM maintenance will be established by focal real-time silencing of specific cell types and real-time jittering of spiking in those cells. Second, sufficient components (neuronal codes) will be determined by a circuit-training phase, in which novel associations between synthetic brain patterns and behaviorally-relevant short-term memory traces will be established. The first class is equivalent to erasing memories and the second to their writing. Together, these manipulations are expected to reveal global and local circuit mechanisms that facilitate STM maintenance in intact animals
|year||authors and title||journal||last update|
Jonathan Platkiewicz, Eran Stark, Asohan Amarasingham
Spike-Centered Jitter Can Mistake Temporal Structure
published pages: 783-803, ISSN: 0899-7667, DOI: 10.1162/NECO_a_00927
|Neural Computation 29/3||2019-06-19|
Lisa Roux, Bo Hu, Ronny Eichler, Eran Stark, GyÃ¶rgy BuzsÃ¡ki
Sharp wave ripples during learning stabilize the hippocampal spatial map
published pages: 845-853, ISSN: 1097-6256, DOI: 10.1038/nn.4543
|Nature Neuroscience 20/6||2019-06-19|
Komal Kampasi, Eran Stark, John Seymour, Kyounghwan Na, Herbert G. Winful, GyÃ¶rgy BuzsÃ¡ki, Kensall D. Wise, Euisik Yoon
Fiberless multicolor neural optoelectrode for in vivo circuit analysis
published pages: 1-13, ISSN: 2045-2322, DOI: 10.1038/srep30961
|Scientific Reports 6/1||2019-06-19|
Komal Kampasi, Daniel F. English, John Seymour, Eran Stark, Sam McKenzie, MihÃ¡ly VÃ¶rÃ¶slakos, GyÃ¶rgy BuzsÃ¡ki, Kensall D. Wise, Euisik Yoon
Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes
published pages: 1-16, ISSN: 2055-7434, DOI: 10.1038/s41378-018-0009-2
|Microsystems & Nanoengineering 4/1||2019-06-07|
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