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HIRESMEMMANIP SIGNED

Spiking network mechanisms underlying short term memory

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EC-Contrib. €

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Project "HIRESMEMMANIP" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙500˙000.00

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 Project objective

Short term memory (STM) is impaired at old age and a host of neuropsychiatric disorders, and has been the focus of a multitude of psychological and theoretical studies. However, the underlying neuronal circuit mechanisms remain elusive, mainly due to the lack of experimental tools: we suggest that rapid manipulations at the neuronal level are required for deciphering underlying mechanisms. We have developed an approach combining large-scale extracellular recordings and high density multi-site/multi-color optical stimulation (“diode-probes”), which enables high resolution closed-loop manipulation of multiple circuit elements in intact, free, behaving rodents. After training mice and rats to perform bridging-free STM-tasks, we will evaluate local circuit mechanisms in hippocampus and prefrontal cortex. Two broad classes of manipulations will be used: First, necessary components and timescales needed for STM maintenance will be established by focal real-time silencing of specific cell types and real-time jittering of spiking in those cells. Second, sufficient components (neuronal codes) will be determined by a circuit-training phase, in which novel associations between synthetic brain patterns and behaviorally-relevant short-term memory traces will be established. The first class is equivalent to erasing memories and the second to their writing. Together, these manipulations are expected to reveal global and local circuit mechanisms that facilitate STM maintenance in intact animals

 Publications

year authors and title journal last update
List of publications.
2017 Jonathan Platkiewicz, Eran Stark, Asohan Amarasingham
Spike-Centered Jitter Can Mistake Temporal Structure
published pages: 783-803, ISSN: 0899-7667, DOI: 10.1162/NECO_a_00927
Neural Computation 29/3 2019-06-19
2017 Lisa Roux, Bo Hu, Ronny Eichler, Eran Stark, György Buzsáki
Sharp wave ripples during learning stabilize the hippocampal spatial map
published pages: 845-853, ISSN: 1097-6256, DOI: 10.1038/nn.4543
Nature Neuroscience 20/6 2019-06-19
2016 Komal Kampasi, Eran Stark, John Seymour, Kyounghwan Na, Herbert G. Winful, György Buzsáki, Kensall D. Wise, Euisik Yoon
Fiberless multicolor neural optoelectrode for in vivo circuit analysis
published pages: 1-13, ISSN: 2045-2322, DOI: 10.1038/srep30961
Scientific Reports 6/1 2019-06-19
2018 Komal Kampasi, Daniel F. English, John Seymour, Eran Stark, Sam McKenzie, Mihály Vöröslakos, György Buzsáki, Kensall D. Wise, Euisik Yoon
Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes
published pages: 1-16, ISSN: 2055-7434, DOI: 10.1038/s41378-018-0009-2
Microsystems & Nanoengineering 4/1 2019-06-07

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