Explore the words cloud of the INTEGRATE project. It provides you a very rough idea of what is the project "INTEGRATE" about.
The following table provides information about the project.
UNIVERSITE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙499˙714 €|
|EC max contribution||2˙499˙714 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2021-09-30|
Take a look of project's partnership.
|1||UNIVERSITE DE LAUSANNE||CH (LAUSANNE)||coordinator||2˙499˙714.00|
During evolution the brain has selected glucose as a main source of metabolic energy. This has imposed homeostatic and behavioral constraints. First, the glycemic levels must be maintained at a minimum of ~5 mM to ensure constant energy supply to the brain. Second, a high reward value has to be attributed to glucose-containing foods to increase the motivation to obtain them. These homeostatic and hedonic regulations depend on glucose sensing cells and neuronal circuits in the central nervous system. These cells and circuits regulate the activity of the sympathetic and parasympathetic nerves, which control the function of peripheral organs (liver, fat, muscles) and the secretion of glucagon and insulin by pancreatic islet cells. They also attribute a reward value to glucose-containing foods to control food-seeking behavior, a process that involves the mesolimbic dopaminergic system. Here, we will focus on three interrelated aims: 1. Identify the physiological role of glucose sensing neurons of the ventromedial hypothalamic nucleus (VMN, a key feeding and glucoregulatory center) in glucose homeostasis and food preference; identify their cellular diversity and their molecular make-up; and characterize their deregulations in metabolic diseases. 2. Characterize the molecular physiology of glucose sensing neurons of the paraventricular thalamus, which modulate the activity of the mesolimbic dopaminergic system to control motivated sucrose-seeking behavior; determine their control by other interoceptive signals, including from glucose sensing cells of the VMN. 3. Establish new molecular approaches to characterize, at the molecular and functional levels, the impact of early postnatal nutrition on the development and function of central glucose sensing cells in the control of adult animal physiology. These studies will open-up new perspectives in the understanding of homeostatic and hedonic regulatory pathways, which preserve metabolic health over a lifetime.
|year||authors and title||journal||last update|
Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman, Bernard Thorens
Î±-cell glucokinase suppresses glucose-regulated glucagon secretion
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03034-0
|Nature Communications 9/1||2019-09-05|
Hongxia Lei, FrÃ©dÃ©ric Preitner, GwenaÃ«l LabouÃ¨be, Rolf Gruetter, Bernard Thorens
Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow
published pages: 0271678X1876674, ISSN: 0271-678X, DOI: 10.1177/0271678x18766743
|Journal of Cerebral Blood Flow & Metabolism||2019-08-29|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INTEGRATE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "INTEGRATE" are provided by the European Opendata Portal: CORDIS opendata.
Broadband Quantum-Limited Parametric Amplifier for Astronomy and Quantum Information TechnologyRead More
Elucidating the development of sexually-dimorphic circuits: from molecular mechanisms to synapses and behaviorRead More
Investigation and Monitoring of Time-varying Environments on Macro and Nano ScalesRead More