Opendata, web and dolomites

INTEGRATE SIGNED

Central integration of metabolic and hedonic cues in metabolic health

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 INTEGRATE project word cloud

Explore the words cloud of the INTEGRATE project. It provides you a very rough idea of what is the project "INTEGRATE" about.

circuits    levels    energy    health    liver    preference    foods    regulate    obtain    sympathetic    homeostatic    modulate    insulin    diversity    brain    ventromedial    hypothalamic    organs    minimum    imposed    glycemic    paraventricular    metabolic    glucagon    mm    hedonic    neurons    physiological    behavior    adult    glucose    peripheral    pancreatic    parasympathetic    cellular    interoceptive    containing    constraints    molecular    regulations    nutrition    reward    muscles    attribute    interrelated    preserve    thalamus    seeking    evolution    nerves    neuronal    food    animal    motivation    nervous    feeding    maintained       constant    mesolimbic    cells    postnatal    secretion    physiology    sensing    lifetime    attributed    signals    supply    central    fat    first    during    islet    source    diseases    homeostasis    nucleus    dopaminergic    deregulations    vmn    glucoregulatory    center    motivated    functional    regulatory    sucrose    behavioral    function    perspectives   

Project "INTEGRATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙499˙714 €
 EC max contribution 2˙499˙714 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 2˙499˙714.00

Map

 Project objective

During evolution the brain has selected glucose as a main source of metabolic energy. This has imposed homeostatic and behavioral constraints. First, the glycemic levels must be maintained at a minimum of ~5 mM to ensure constant energy supply to the brain. Second, a high reward value has to be attributed to glucose-containing foods to increase the motivation to obtain them. These homeostatic and hedonic regulations depend on glucose sensing cells and neuronal circuits in the central nervous system. These cells and circuits regulate the activity of the sympathetic and parasympathetic nerves, which control the function of peripheral organs (liver, fat, muscles) and the secretion of glucagon and insulin by pancreatic islet cells. They also attribute a reward value to glucose-containing foods to control food-seeking behavior, a process that involves the mesolimbic dopaminergic system. Here, we will focus on three interrelated aims: 1. Identify the physiological role of glucose sensing neurons of the ventromedial hypothalamic nucleus (VMN, a key feeding and glucoregulatory center) in glucose homeostasis and food preference; identify their cellular diversity and their molecular make-up; and characterize their deregulations in metabolic diseases. 2. Characterize the molecular physiology of glucose sensing neurons of the paraventricular thalamus, which modulate the activity of the mesolimbic dopaminergic system to control motivated sucrose-seeking behavior; determine their control by other interoceptive signals, including from glucose sensing cells of the VMN. 3. Establish new molecular approaches to characterize, at the molecular and functional levels, the impact of early postnatal nutrition on the development and function of central glucose sensing cells in the control of adult animal physiology. These studies will open-up new perspectives in the understanding of homeostatic and hedonic regulatory pathways, which preserve metabolic health over a lifetime.

 Publications

year authors and title journal last update
List of publications.
2018 Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman, Bernard Thorens
α-cell glucokinase suppresses glucose-regulated glucagon secretion
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03034-0
Nature Communications 9/1 2019-09-05
2018 Hongxia Lei, Frédéric Preitner, Gwenaël Labouèbe, Rolf Gruetter, Bernard Thorens
Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow
published pages: 0271678X1876674, ISSN: 0271-678X, DOI: 10.1177/0271678x18766743
Journal of Cerebral Blood Flow & Metabolism 2019-08-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INTEGRATE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INTEGRATE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TRUST (2018)

Truth and Semantics

Read More  

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More