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INTEGRATE SIGNED

Central integration of metabolic and hedonic cues in metabolic health

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 INTEGRATE project word cloud

Explore the words cloud of the INTEGRATE project. It provides you a very rough idea of what is the project "INTEGRATE" about.

constant    feeding    food    preserve    obtain    regulations    motivation    liver    sympathetic    neurons    thalamus    center    imposed    sensing    during    seeking    ventromedial    mesolimbic    molecular    postnatal    nerves    health    attributed    regulatory    homeostatic    vmn    islet    signals    source    attribute       organs    diseases    physiological    neuronal    first    cells    maintained    interoceptive    modulate    behavioral    brain    deregulations    containing    evolution    sucrose    adult    central    secretion    lifetime    levels    nutrition    circuits    foods    fat    supply    mm    regulate    glycemic    constraints    homeostasis    parasympathetic    nervous    hypothalamic    muscles    diversity    animal    perspectives    dopaminergic    motivated    reward    preference    energy    glucose    nucleus    cellular    glucoregulatory    paraventricular    functional    minimum    interrelated    metabolic    glucagon    hedonic    behavior    function    peripheral    insulin    pancreatic    physiology   

Project "INTEGRATE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙499˙714 €
 EC max contribution 2˙499˙714 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 2˙499˙714.00

Map

 Project objective

During evolution the brain has selected glucose as a main source of metabolic energy. This has imposed homeostatic and behavioral constraints. First, the glycemic levels must be maintained at a minimum of ~5 mM to ensure constant energy supply to the brain. Second, a high reward value has to be attributed to glucose-containing foods to increase the motivation to obtain them. These homeostatic and hedonic regulations depend on glucose sensing cells and neuronal circuits in the central nervous system. These cells and circuits regulate the activity of the sympathetic and parasympathetic nerves, which control the function of peripheral organs (liver, fat, muscles) and the secretion of glucagon and insulin by pancreatic islet cells. They also attribute a reward value to glucose-containing foods to control food-seeking behavior, a process that involves the mesolimbic dopaminergic system. Here, we will focus on three interrelated aims: 1. Identify the physiological role of glucose sensing neurons of the ventromedial hypothalamic nucleus (VMN, a key feeding and glucoregulatory center) in glucose homeostasis and food preference; identify their cellular diversity and their molecular make-up; and characterize their deregulations in metabolic diseases. 2. Characterize the molecular physiology of glucose sensing neurons of the paraventricular thalamus, which modulate the activity of the mesolimbic dopaminergic system to control motivated sucrose-seeking behavior; determine their control by other interoceptive signals, including from glucose sensing cells of the VMN. 3. Establish new molecular approaches to characterize, at the molecular and functional levels, the impact of early postnatal nutrition on the development and function of central glucose sensing cells in the control of adult animal physiology. These studies will open-up new perspectives in the understanding of homeostatic and hedonic regulatory pathways, which preserve metabolic health over a lifetime.

 Publications

year authors and title journal last update
List of publications.
2018 Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman, Bernard Thorens
α-cell glucokinase suppresses glucose-regulated glucagon secretion
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03034-0
Nature Communications 9/1 2019-09-05
2018 Hongxia Lei, Frédéric Preitner, Gwenaël Labouèbe, Rolf Gruetter, Bernard Thorens
Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow
published pages: 0271678X1876674, ISSN: 0271-678X, DOI: 10.1177/0271678x18766743
Journal of Cerebral Blood Flow & Metabolism 2019-08-29

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