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Proton CT reconstruction with a Cone Beam CT prior

Total Cost €


EC-Contrib. €






Project "protonCBCT" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

'Proton therapy has become a superioralternative to conventional radiotherapy for certain clinical indications. It potentially allows to deliver high dose to the tumor while sparing healthy surrounding tissue. However, a reduction of treatment uncertainties is required to fully exploit this advantage and precise knowledge of the relative stopping power (RSP) of the patient tissues on the day of treatment is needed to correctly predict the proton range in the treatment planning system (TPS). Modern imaging technology plays a key role here.

Developing novel methods to produce volumetric images of the patient while positioned on the treatment couch lies at the heart of this proposal. More specifically, I propose to explore strategies to merge proton computed tomography (pCT) and cone beam CT (CBCT) acquired directly in the treatment room based on which accurate dose-of-the-day calculations can be performed. The idea arises from the complementary advantages of proton and X-ray imaging: The former potentially provides a highly accurate volumetric RSP map while the latter produces images of high spatial resolution.

I will develop and implement a 'protonCBCT' reconstruction algorithm which uses the CBCT data as prior, compensates for image noise through dedicated regularization methods, and builds the pCT image using state-of-the-art reconstruction techniques. I emphasize the clinical applicability of the project: I will A) consider pCT and CBCT data acquired with clinically available imaging technology, B) propose a treatment work flow to incorporate the new protonCBCT imaging, and C) validate our methods using clinically proven treatment planning software.

To my knowledge, a combined pCT/CBCT imaging modality in a clinical context has not been studied yet. It has the potential of providing volumetric images with excellent quality acquired in situ directly prior to a treatment session and could eventually lead to higher treatment quality in proton therapy.'


year authors and title journal last update
List of publications.
2019 Feriel Khellaf, Nils Krah, Ilaria Rinaldi, Jean Michel Létang, Simon Rit
Effects of transverse heterogeneities on the most likely path of protons
published pages: 65003, ISSN: 1361-6560, DOI: 10.1088/1361-6560/ab02a8
Physics in Medicine & Biology 64/6 2019-09-30
2019 N Krah, V Patera, S Rit, A Schiavi, I Rinaldi
Regularised patient-specific stopping power calibration for proton therapy planning based on proton radiographic images
published pages: 65008, ISSN: 1361-6560, DOI: 10.1088/1361-6560/ab03db
Physics in Medicine & Biology 64/6 2019-09-30
2018 N Krah, F Khellaf, J M Létang, S Rit, I Rinaldi
A comprehensive theoretical comparison of proton imaging set-ups in terms of spatial resolution
published pages: 135013, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aaca1f
Physics in Medicine & Biology 63/13 2019-09-30
2018 N Krah, L De Marzi, A Patriarca, G Pittá, I Rinaldi
Proton radiography with a commercial range telescope detector using dedicated post processing methods
published pages: 205016, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aae043
Physics in Medicine & Biology 63/20 2019-09-30

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The information about "PROTONCBCT" are provided by the European Opendata Portal: CORDIS opendata.

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