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GlycoNanoPep

Glyco and Nano Peptide Conjugates for Selective Cell Penetration

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "GlycoNanoPep" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA 

Organization address
address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
city: SANTIAGO DE COMPOSTELA
postcode: 15782
website: http://www.usc.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) coordinator 158˙121.00

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 Project objective

The next generation therapeutic agents such as proteins, nucleotides, cytotoxic agents and molecular probes hold promising properties to solve many crucial health issues. However, efficient and selective transport of this therapeutic cargos and imaging probes into the right cells at the right moment stands as a fundamental limitation of these new technologies.

In this action we will develop a new generation of highly efficient, selective and biocompatible supramolecular vehicles for specific cell delivery. This strategy will consist in the implementation of dynamic bonds as linkers for glycoconjugated cell penetrating peptides. These peptide hybrids will be recognized very specifically carbohydrate receptors and internalized. These stimuli responsive dynamic bonds will assist in critical steps of the delivery process such as the cargo release and endosomal escape.

We will expand this strategy to incorporate glycopeptides conjugated into multifunctional nanoparticles through host-guest interactions. We will implement state of the art synthetic, biophysics and cell biology techniques to identify new supramolecular selective membrane transporters.

This action will combine the glycochemistry background of the applicant with the expertise in membrane transport of the host group. The potential discoveries will trigger new opportunities in the delivery of the next-generation probes and proteins (i.e. CRISPR).

 Publications

year authors and title journal last update
List of publications.
2018 Alejandro Méndez-Ardoy, Juan R. Granja, Javier Montenegro
pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets
published pages: 391-396, ISSN: 2055-6756, DOI: 10.1039/c8nh00009c
Nanoscale Horizons 3/4 2020-01-23
2018 Alejandro Méndez‐Ardoy, Irene Lostalé‐Seijo, Javier Montenegro
Where in the Cell Is our Cargo? Methods Currently Used To Study Intracellular Cytosolic Localisation
published pages: 488-498, ISSN: 1439-4227, DOI: 10.1002/cbic.201800390
ChemBioChem 20/4 2020-01-23

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