Explore the words cloud of the ImmunoBile project. It provides you a very rough idea of what is the project "ImmunoBile" about.
The following table provides information about the project.
UNIVERSITE DE LILLE II - DROIT ET SANTE
There are not information about this coordinator. Please contact Fabio for more information, thanks.
|Coordinator Country||France [FR]|
|Total cost||2˙500˙000 €|
|EC max contribution||2˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-09-01 to 2021-08-31|
Take a look of project's partnership.
|1||UNIVERSITE DE LILLE||FR (LILLE)||coordinator||2˙500˙000.00|
|2||UNIVERSITE DE LILLE II - DROIT ET SANTE||FR (Lille)||coordinator||0.00|
The role of chronic inflammation in obesity, metabolic and cardiovascular diseases is increasingly recognized. Bile acids (BA), synthesized in the liver and modified by the gut flora, facilitate lipid absorption in the intestine. BA modulate lipid and glucose homeostasis by activating the nuclear receptor FXR and the GPCR TGR5. Intriguingly, peripheral BA concentrations are elevated in type 2 diabetes (T2D) and FXR mediates the beneficial metabolic response to gastric bypass in mice. The immune system plays an important role in the cross-talk with metabolic tissues, such as liver, intestine and adipose tissues. However, whether BA modulate immune cell function is unknown. Our unpublished results identifying FXR and TGR5 expression in lymphoid cells, prompt us to study their role in the regulation of glucose and lipid metabolism through immune cell modulation. Using reporter mice and specific ligands, we will characterize the immune cells expressing active FXR and TGR5. We will determine their role in metabolism and inflammation by immune cell-specific gene inactivation in models of obesity, T2D and elevated peripheral blood BA concentrations. Mass cytometry, cell sorting and single cell transcriptomic analysis will allow the identification of gene networks regulated by BA and their receptors. As microbiota generate biologically active secondary BA, we will assess the impact of microbiota depletion and subsequent BA acid pool modifications on immune cell populations. Translational studies in humans with altered BA metabolism and pharmacological treatment with anti-diabetic BA sequestrants will allow assessment of alterations in immune functions. This project aims to identify an hitherto unexplored role of BA through modulation of the immune system on T2D, NAFLD and dyslipidemia. Success of the project critically depends on an integrative approach uniquely undertaken in my laboratory through its unique multidisciplinary expertise in basic and translational biology.
|year||authors and title||journal||last update|
Oscar ChÃ¡vez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease
published pages: 1679-1694.e3, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2017.01.055
Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, LoÃ¯c Belloy, Sophie Lestavel, Emmanuelle Vallez, Emilie Dorchies, Isabelle Duplan, Emmanuel Sevin, Maxime Culot, Fabien Gosselet, Rajaa Boulahjar, Adrien Herledan, Bart Staels, Benoit Deprez, Anne Tailleux, Julie Charton
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance
published pages: 4185-4211, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01873
|Journal of Medicinal Chemistry 60/10||2019-08-06|
Maheul Ploton, Claire Mazuy, CÃ©line Gheeraert, Vanessa Dubois, Alexandre Berthier, Julie Dubois-Chevalier, Xavier MarÃ©chal, Kadiombo Bantubungi, HÃ©lÃ¨ne Diemer, Sarah CianfÃ©rani, Jean-Marc Strub, Audrey Helleboid-Chapman, JÃ©rÃ´me Eeckhoute, Bart Staels, Philippe Lefebvre
The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis
published pages: 1099-1109, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.06.022
|Journal of Hepatology 69/5||2019-08-06|
Benoit Pourcet, Mathilde Zecchin, Lise Ferri, Justine Beauchamp, Sadicha Sitaula, Cyrielle Billon, StÃ©phane Delhaye, Jonathan Vanhoutte, Alicia Mayeuf-Louchart, Quentin Thorel, Joel T. Haas, JÃ©rome Eeckhoute, David Dombrowicz, Christian Duhem, Alexis Boulinguiez, Steve Lancel, Yasmine Sebti, Thomas P. Burris, Bart Staels, HÃ©lÃ¨ne M. Duez
Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice
published pages: 1449-1464.e20, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2017.12.019
Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-FranÃ§ois Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction
published pages: 271-283, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-313316
Julie Dubois-Chevalier, Vanessa Dubois, HÃ©lÃ¨ne Dehondt, Parisa Mazrooei, Claire Mazuy, AurÃ©lien A. SÃ©randour, CÃ©line Gheeraert, Penderia Guillaume, Eric BaugÃ©, Bruno Derudas, Nathalie Hennuyer, RÃ©jane Paumelle, Guillemette Marot, Jason S. Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, JÃ©rÃ´me Eeckhoute
The logic of transcriptional regulator recruitment architecture at cis -regulatory modules controlling liver functions
published pages: 985-996, ISSN: 1088-9051, DOI: 10.1101/gr.217075.116
|Genome Research 27/6||2019-06-13|
Alicia Mayeuf-Louchart, Quentin Thorel, StÃ©phane Delhaye, Justine Beauchamp, Christian Duhem, Anne Danckaert, Steve Lancel, Benoit Pourcet, Estelle Woldt, Alexis Boulinguiez, Lise Ferri, Mathilde Zecchin, Bart Staels, Yasmine Sebti, HÃ©lÃ¨ne Duez
Rev-erb-Î± regulates atrophy-related genes to control skeletal muscle mass
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14596-2
|Scientific Reports 7/1||2019-06-13|
Benoit Pourcet, Bart Staels
Alternative macrophages in atherosclerosis: not always protective!
published pages: 910-912, ISSN: 0021-9738, DOI: 10.1172/JCI120123
|Journal of Clinical Investigation 128/3||2019-06-13|
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