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ImmunoBile SIGNED

Bile acid, immune-metabolism, lipid and glucose homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ImmunoBile project word cloud

Explore the words cloud of the ImmunoBile project. It provides you a very rough idea of what is the project "ImmunoBile" about.

inflammation    dyslipidemia    generate    basic    functions    cells    obesity    ligands    anti    sequestrants    diabetes    subsequent    cardiovascular    treatment    unpublished    fxr    active    talk    depends    diseases    gastric    biology    function    intestine    intriguingly    gene    unknown    peripheral    lipid    mice    single    expertise    elevated    networks    modified    humans    expression    modulation    modifications    gut    mass    modulate    regulation    prompt    receptor    models    ba    nafld    transcriptomic    chronic    unexplored    expressing    undertaken    tissues    secondary    bile    activating    diabetic    biologically    microbiota    uniquely    metabolic    blood    translational    adipose    synthesized    mediates    pool    regulated    beneficial    plays    acid    sorting    cross    hitherto    metabolism    homeostasis    flora    multidisciplinary    integrative    laboratory    cell    tgr5    populations    altered    receptors    t2d    inactivation    critically    absorption    depletion    gpcr    pharmacological    alterations    bypass    reporter    concentrations    nuclear    acids    liver    identification    cytometry    lymphoid    glucose    immune   

Project "ImmunoBile" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LILLE II - DROIT ET SANTE 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LILLE FR (LILLE) coordinator 2˙500˙000.00
2    UNIVERSITE DE LILLE II - DROIT ET SANTE FR (Lille) coordinator 0.00

Map

 Project objective

The role of chronic inflammation in obesity, metabolic and cardiovascular diseases is increasingly recognized. Bile acids (BA), synthesized in the liver and modified by the gut flora, facilitate lipid absorption in the intestine. BA modulate lipid and glucose homeostasis by activating the nuclear receptor FXR and the GPCR TGR5. Intriguingly, peripheral BA concentrations are elevated in type 2 diabetes (T2D) and FXR mediates the beneficial metabolic response to gastric bypass in mice. The immune system plays an important role in the cross-talk with metabolic tissues, such as liver, intestine and adipose tissues. However, whether BA modulate immune cell function is unknown. Our unpublished results identifying FXR and TGR5 expression in lymphoid cells, prompt us to study their role in the regulation of glucose and lipid metabolism through immune cell modulation. Using reporter mice and specific ligands, we will characterize the immune cells expressing active FXR and TGR5. We will determine their role in metabolism and inflammation by immune cell-specific gene inactivation in models of obesity, T2D and elevated peripheral blood BA concentrations. Mass cytometry, cell sorting and single cell transcriptomic analysis will allow the identification of gene networks regulated by BA and their receptors. As microbiota generate biologically active secondary BA, we will assess the impact of microbiota depletion and subsequent BA acid pool modifications on immune cell populations. Translational studies in humans with altered BA metabolism and pharmacological treatment with anti-diabetic BA sequestrants will allow assessment of alterations in immune functions. This project aims to identify an hitherto unexplored role of BA through modulation of the immune system on T2D, NAFLD and dyslipidemia. Success of the project critically depends on an integrative approach uniquely undertaken in my laboratory through its unique multidisciplinary expertise in basic and translational biology.

 Publications

year authors and title journal last update
List of publications.
2017 Oscar Chávez-Talavera, Anne Tailleux, Philippe Lefebvre, Bart Staels
Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease
published pages: 1679-1694.e3, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2017.01.055
Gastroenterology 152/7 2019-08-06
2017 Manuel Lasalle, Vanessa Hoguet, Nathalie Hennuyer, Florence Leroux, Catherine Piveteau, Loïc Belloy, Sophie Lestavel, Emmanuelle Vallez, Emilie Dorchies, Isabelle Duplan, Emmanuel Sevin, Maxime Culot, Fabien Gosselet, Rajaa Boulahjar, Adrien Herledan, Bart Staels, Benoit Deprez, Anne Tailleux, Julie Charton
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance
published pages: 4185-4211, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01873
Journal of Medicinal Chemistry 60/10 2019-08-06
2018 Maheul Ploton, Claire Mazuy, Céline Gheeraert, Vanessa Dubois, Alexandre Berthier, Julie Dubois-Chevalier, Xavier Maréchal, Kadiombo Bantubungi, Hélène Diemer, Sarah Cianférani, Jean-Marc Strub, Audrey Helleboid-Chapman, Jérôme Eeckhoute, Bart Staels, Philippe Lefebvre
The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis
published pages: 1099-1109, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.06.022
Journal of Hepatology 69/5 2019-08-06
2018 Benoit Pourcet, Mathilde Zecchin, Lise Ferri, Justine Beauchamp, Sadicha Sitaula, Cyrielle Billon, Stéphane Delhaye, Jonathan Vanhoutte, Alicia Mayeuf-Louchart, Quentin Thorel, Joel T. Haas, Jérome Eeckhoute, David Dombrowicz, Christian Duhem, Alexis Boulinguiez, Steve Lancel, Yasmine Sebti, Thomas P. Burris, Bart Staels, Hélène M. Duez
Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice
published pages: 1449-1464.e20, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2017.12.019
Gastroenterology 154/5 2019-06-13
2018 Emilie Catry, Laure B Bindels, Anne Tailleux, Sophie Lestavel, Audrey M Neyrinck, Jean-François Goossens, Irina Lobysheva, Hubert Plovier, Ahmed Essaghir, Jean-Baptiste Demoulin, Caroline Bouzin, Barbara D Pachikian, Patrice D Cani, Bart Staels, Chantal Dessy, Nathalie M Delzenne
Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction
published pages: 271-283, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-313316
Gut 67/2 2019-06-13
2017 Julie Dubois-Chevalier, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, Aurélien A. Sérandour, Céline Gheeraert, Penderia Guillaume, Eric Baugé, Bruno Derudas, Nathalie Hennuyer, Réjane Paumelle, Guillemette Marot, Jason S. Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
The logic of transcriptional regulator recruitment architecture at cis -regulatory modules controlling liver functions
published pages: 985-996, ISSN: 1088-9051, DOI: 10.1101/gr.217075.116
Genome Research 27/6 2019-06-13
2017 Alicia Mayeuf-Louchart, Quentin Thorel, Stéphane Delhaye, Justine Beauchamp, Christian Duhem, Anne Danckaert, Steve Lancel, Benoit Pourcet, Estelle Woldt, Alexis Boulinguiez, Lise Ferri, Mathilde Zecchin, Bart Staels, Yasmine Sebti, Hélène Duez
Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14596-2
Scientific Reports 7/1 2019-06-13
2018 Benoit Pourcet, Bart Staels
Alternative macrophages in atherosclerosis: not always protective!
published pages: 910-912, ISSN: 0021-9738, DOI: 10.1172/JCI120123
Journal of Clinical Investigation 128/3 2019-06-13

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The information about "IMMUNOBILE" are provided by the European Opendata Portal: CORDIS opendata.

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