Explore the words cloud of the Totipotency project. It provides you a very rough idea of what is the project "Totipotency" about.
The following table provides information about the project.
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙859˙560 €|
|EC max contribution||2˙859˙560 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-08-01 to 2021-07-31|
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|1||FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION||CH (BASEL)||coordinator||2˙859˙560.00|
In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. It coincides with translation and degradation of maternally provided transcripts, initiation of global transcription called zygotic genome activation (ZGA), and “epigenetic reprogramming” of germline chromatin states into an embryonic state. The molecular mechanisms underlying this exquisite reprogramming of cell fate are barely understood.
This research program has the ambitious goal to identify and characterize in a comprehensive way the transcription factors and chromatin regulators which initiate and regulate ZGA in a parental specific manner in early mouse embryos. We will utilize novel and highly sensitive genomic approaches to measure nascent transcription and determine open and modified chromatin landscapes in oocytes and early embryos, wild-type and conditionally deficient for major epigenetic modifiers. We will apply computational approaches to identify candidate TFs and histone modifiers controlling ZGA. We will use molecular and developmental biology approaches, combined with sensitive quantitative live-imaging, to interrogate the function of TFs and their binding sites for ZGA.
We will further investigate the significance of possible paternal inheritance of nucleosomes at CpG islands for gene regulation during ZGA and later development by depleting nucleosomes from mature sperm by using sophisticated conditional deficiency and gain-of-function mouse models. By transferring nuclei of immature spermatid and mature sperm into oocytes, we will interrogate the relevance of nucleosome eviction during spermatogenesis, as a possibly truly epigenetic reprogramming process, for defining embryonic competence.
ERC funding would represent a crucial contribution to dissecting the molecular mechanisms underlying acquisition of totipotency in mouse embryos and may impact on the use of Assisted Reproductive Technologies in human med
|year||authors and title||journal||last update|
Mark E. Gill, Antoine H. F. M. Peters
Toward human egg-like cells in vitro
published pages: 291-292, ISSN: 0036-8075, DOI: 10.1126/science.aav3479
Maaike Welling, Manuel Alexander Mohr, Aaron Ponti, Lluc Rullan Sabater, Andrea Boni, Yumiko K Kawamura, Prisca Liberali, Antoine HFM Peters, Pawel Pelczar, Periklis Pantazis
Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.44491
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