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Totipotency SIGNED

Transcriptional and Epigenetic Regulation of Totipotency in Mouse Early Embryos.

Total Cost €

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EC-Contrib. €

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Partnership

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 Totipotency project word cloud

Explore the words cloud of the Totipotency project. It provides you a very rough idea of what is the project "Totipotency" about.

sperm    conditional    gain    oocytes    totipotent    computational    mature    developmental    mammals    paternal    differentiated    genomic    barely    nucleosome    gametes    candidate    parental    possibly    deficiency    immature    regulators    totipotency    islands    function    molecular    mechanisms    transferring    fusion    relevance    dissecting    germline    truly    spermatogenesis    exquisite    fate    inheritance    activation    transcripts    modifiers    mouse    med    biology    nucleosomes    combined    erc    significance    maternally    cpg    conditionally    zygote    manner    cell    embryos    genome    reproductive    regulate    reprogramming    transcription    spermatid    competence    deficient    sites    depleting    quantitative    tfs    binding    imaging    modified    landscapes    underlying    human    translation    gives    eviction    regulation    sophisticated    histone    zygotic    contribution    degradation    coincides    nuclei    utilize    epigenetic    global    chromatin    assisted    gene    acquisition    embryonic    nascent    interrogate    later    wild    initiate    organism    zga    sensitive    technologies    initiation    live    models   

Project "Totipotency" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙859˙560 €
 EC max contribution 2˙859˙560 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙859˙560.00

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 Project objective

In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. It coincides with translation and degradation of maternally provided transcripts, initiation of global transcription called zygotic genome activation (ZGA), and “epigenetic reprogramming” of germline chromatin states into an embryonic state. The molecular mechanisms underlying this exquisite reprogramming of cell fate are barely understood.

This research program has the ambitious goal to identify and characterize in a comprehensive way the transcription factors and chromatin regulators which initiate and regulate ZGA in a parental specific manner in early mouse embryos. We will utilize novel and highly sensitive genomic approaches to measure nascent transcription and determine open and modified chromatin landscapes in oocytes and early embryos, wild-type and conditionally deficient for major epigenetic modifiers. We will apply computational approaches to identify candidate TFs and histone modifiers controlling ZGA. We will use molecular and developmental biology approaches, combined with sensitive quantitative live-imaging, to interrogate the function of TFs and their binding sites for ZGA.

We will further investigate the significance of possible paternal inheritance of nucleosomes at CpG islands for gene regulation during ZGA and later development by depleting nucleosomes from mature sperm by using sophisticated conditional deficiency and gain-of-function mouse models. By transferring nuclei of immature spermatid and mature sperm into oocytes, we will interrogate the relevance of nucleosome eviction during spermatogenesis, as a possibly truly epigenetic reprogramming process, for defining embryonic competence.

ERC funding would represent a crucial contribution to dissecting the molecular mechanisms underlying acquisition of totipotency in mouse embryos and may impact on the use of Assisted Reproductive Technologies in human med

 Publications

year authors and title journal last update
List of publications.
2018 Mark E. Gill, Antoine H. F. M. Peters
Toward human egg-like cells in vitro
published pages: 291-292, ISSN: 0036-8075, DOI: 10.1126/science.aav3479
Science 362/6412 2019-06-03
2019 Maaike Welling, Manuel Alexander Mohr, Aaron Ponti, Lluc Rullan Sabater, Andrea Boni, Yumiko K Kawamura, Prisca Liberali, Antoine HFM Peters, Pawel Pelczar, Periklis Pantazis
Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.44491
eLife 8 2019-06-03

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The information about "TOTIPOTENCY" are provided by the European Opendata Portal: CORDIS opendata.

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