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Totipotency SIGNED

Transcriptional and Epigenetic Regulation of Totipotency in Mouse Early Embryos.

Total Cost €

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EC-Contrib. €

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Partnership

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 Totipotency project word cloud

Explore the words cloud of the Totipotency project. It provides you a very rough idea of what is the project "Totipotency" about.

spermatid    spermatogenesis    totipotent    degradation    modifiers    fusion    computational    gain    zygotic    reproductive    regulate    genomic    initiate    binding    reprogramming    cpg    islands    oocytes    mechanisms    differentiated    tfs    immature    activation    combined    human    eviction    technologies    germline    med    live    wild    quantitative    gametes    fate    molecular    possibly    zga    chromatin    assisted    regulators    embryonic    paternal    sensitive    contribution    sperm    developmental    dissecting    candidate    models    embryos    initiation    utilize    coincides    manner    barely    imaging    conditional    totipotency    landscapes    significance    mammals    underlying    nucleosome    gene    relevance    gives    sites    deficient    truly    nucleosomes    mature    competence    histone    nascent    epigenetic    translation    erc    interrogate    global    transcripts    mouse    regulation    function    depleting    genome    maternally    inheritance    sophisticated    nuclei    conditionally    deficiency    biology    exquisite    cell    acquisition    later    transcription    organism    zygote    transferring    modified    parental   

Project "Totipotency" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙859˙560 €
 EC max contribution 2˙859˙560 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙859˙560.00

Map

 Project objective

In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. It coincides with translation and degradation of maternally provided transcripts, initiation of global transcription called zygotic genome activation (ZGA), and “epigenetic reprogramming” of germline chromatin states into an embryonic state. The molecular mechanisms underlying this exquisite reprogramming of cell fate are barely understood.

This research program has the ambitious goal to identify and characterize in a comprehensive way the transcription factors and chromatin regulators which initiate and regulate ZGA in a parental specific manner in early mouse embryos. We will utilize novel and highly sensitive genomic approaches to measure nascent transcription and determine open and modified chromatin landscapes in oocytes and early embryos, wild-type and conditionally deficient for major epigenetic modifiers. We will apply computational approaches to identify candidate TFs and histone modifiers controlling ZGA. We will use molecular and developmental biology approaches, combined with sensitive quantitative live-imaging, to interrogate the function of TFs and their binding sites for ZGA.

We will further investigate the significance of possible paternal inheritance of nucleosomes at CpG islands for gene regulation during ZGA and later development by depleting nucleosomes from mature sperm by using sophisticated conditional deficiency and gain-of-function mouse models. By transferring nuclei of immature spermatid and mature sperm into oocytes, we will interrogate the relevance of nucleosome eviction during spermatogenesis, as a possibly truly epigenetic reprogramming process, for defining embryonic competence.

ERC funding would represent a crucial contribution to dissecting the molecular mechanisms underlying acquisition of totipotency in mouse embryos and may impact on the use of Assisted Reproductive Technologies in human med

 Publications

year authors and title journal last update
List of publications.
2018 Mark E. Gill, Antoine H. F. M. Peters
Toward human egg-like cells in vitro
published pages: 291-292, ISSN: 0036-8075, DOI: 10.1126/science.aav3479
Science 362/6412 2019-06-03
2019 Maaike Welling, Manuel Alexander Mohr, Aaron Ponti, Lluc Rullan Sabater, Andrea Boni, Yumiko K Kawamura, Prisca Liberali, Antoine HFM Peters, Pawel Pelczar, Periklis Pantazis
Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.44491
eLife 8 2019-06-03

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