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CoBABATI SIGNED

Cofactor Binding Antibodies – Basic Aspects and Therapeutic Innovations

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Project "CoBABATI" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙255˙000 €
 EC max contribution 1˙255˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙255˙000.00

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 Project objective

The immune repertoire of healthy individuals contains a fraction of antibodies (Abs) that are able to bind with high affinity various endogenous or exogenous low molecular weight compounds, including cofactors essential for the aerobic life, such as riboflavin, heme and ATP. Despite identification of cofactor-binding Abs as a constituent of normal immune repertoires, their fundamental characteristics and have not been systematically investigated. Thus, we do not know the origin, prevalence and physiopathological significance of cofactor-binding Abs. Moreover, the molecular mechanisms of interaction of cofactors with Abs are ill defined. Different proteins use cofactors to extend the chemistry intrinsic to the amino acid sequence of their polypeptide chain(s). Thus, one can speculate that the alliance of Abs with low molecular weight compounds results in the emergence of untypical properties of Abs and offers a strategy for designing a new generation of therapeutic Abs. Moreover, cofactor-binding Abs may be used for delivery of cytotoxic compounds to particular sites in the body, or for scavenging pro-inflammatory compounds. The principal goal of the present proposal is to gain a basic understanding on the fraction of cofactor-binding Abs in immune repertoires and to use this knowledge for the rational design of novel classes of therapeutic Abs. In this project, we will address the following questions: 1) understand the origin and prevalence of cofactor-binding Abs in immune repertoires; 2) characterize the molecular mechanisms of interaction of cofactors with Abs; 3) Understand the physiopathological roles of cofactor-binding Abs, and 4) use cofactor binding for the development of novel types of therapeutic Abs. A comprehensive understanding of various aspects of cofactor-binding Abs should lead to advances in fundamental understanding and in the development of innovative therapeutic and diagnostic tools.

 Publications

year authors and title journal last update
List of publications.
2019 Rémi Noé, Nina Bozinovic, Maxime Lecerf, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov
Use of cysteine as a spectroscopic probe for determination of heme-scavenging capacity of serum proteins and whole human serum
published pages: 311-319, ISSN: 0731-7085, DOI: 10.1016/j.jpba.2019.05.013
Journal of Pharmaceutical and Biomedical Analysis 172 2019-06-06
2019 Cyril Planchais, Ayrin Kök, Alexia Kanyavuz, Valérie Lorin, Timothée Bruel, Florence Guivel-Benhassine, Tim Rollenske, Julie Prigent, Thierry Hieu, Thierry Prazuck, Laurent Lefrou, Hedda Wardemann, Olivier Schwartz, Jordan D. Dimitrov, Laurent Hocqueloux, Hugo Mouquet
HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells
published pages: 572-585.e7, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.03.032
Cell Reports 27/2 2019-05-27
2019 Alexia Kanyavuz, Annaelle Marey-Jarossay, Sébastien Lacroix-Desmazes, Jordan D. Dimitrov
Breaking the law: unconventional strategies for antibody diversification
published pages: , ISSN: 1474-1733, DOI: 10.1038/s41577-019-0126-7
Nature Reviews Immunology 2019-05-27
2019 Nicolas S. Merle, Romain Paule, Juliette Leon, Marie Daugan, Tania Robe-Rybkine, Victoria Poillerat, Carine Torset, Véronique Frémeaux-Bacchi, Jordan D. Dimitrov, Lubka T. Roumenina
P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner
published pages: 6280-6285, ISSN: 0027-8424, DOI: 10.1073/pnas.1814797116
Proceedings of the National Academy of Sciences 116/13 2019-05-27
2019 Marie Wiatr, Nicolas S. Merle, Idris Boudhabhay, Victoria Poillerat, Sofia Rossini, Maxime Lecerf , Srini V. Kaveri, Sébastian Lacroix-Desmazes, Lubka T. Roumenina and Jordan D. Dimitrov 1
Anti-inflammatory Activity of Intravenous Immunoglobulin through Scavenging of Heme
published pages: , ISSN: 0161-5890, DOI:
Molecular Immunology 2019-05-27

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