Explore the words cloud of the ULT-MAS-DNP project. It provides you a very rough idea of what is the project "ULT-MAS-DNP" about.
The following table provides information about the project.
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
|Coordinator Country||France [FR]|
|Total cost||1˙999˙805 €|
|EC max contribution||1˙999˙805 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-07-01 to 2021-06-30|
Take a look of project's partnership.
|1||COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES||FR (PARIS 15)||coordinator||1˙959˙805.00|
|2||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||participant||40˙000.00|
The goal of the project is to develop a new hyperpolarization approach called Magic Angle Spinning Dynamic Nuclear Polarization (MAS-DNP) to reach levels of sensitivity and resolution that have never been achieved, in order to tackle highly relevant chemical and biological questions that remain unanswered so far. Firstly this will provide major advances in NMR crystallography (solving 3D structures by NMR) by showing that distance measurements between nuclei (13C, 15N, etc.) as well as 17O quadrupolar parameters can be extracted from NMR measurements without requiring isotopic labeling. This will be applied to systems that cannot be easily isotopically enriched and for which X-ray analysis is often not suitable. Secondly we propose an innovative strategy to hyperpolarize nuclear spins using MAS-DNP: rather than polarizing the entire system uniformly, we will selectively “light up” regions where we wish to gather important structural information. This will be developed to study protein-ligand interactions (with unprecedented resolution) to answer specific structural questions and potentially impact the field of drug engineering. Finally we will show that the unique experimental setup developed in this project will open up NMR to the routine study of “exotic”, yet ubiquitous and highly informative, nuclei such as 43Ca and 67Zn. Specifically, we will show that MAS-DNP can become a choice technique for the study of diamagnetic metal binding sites, complementing EPR for the study of metalloproteins. These goals will be achieved thanks to the development of original methods and advanced instrumentation, allowing sustainable access to low temperatures (down to 10-20 K) and fast pneumatic sample spinning, under microwave irradiation. We expect to improve the current sensitivity to such an extent that 4 orders of magnitude of experimental timesavings are obtained, resulting in completely new research directions and regimes.
|year||authors and title||journal||last update|
Harish Banda, Sandy PÃ©riÃ©, Barbara Daffos, Pierre-Louis Taberna, Lionel Dubois, Olivier Crosnier, Patrice Simon, Daniel Lee, GaÃ«l De PaÃ«pe, Florence Duclairoir
Sparsely Pillared Graphene Materials for High-Performance Supercapacitors: Improving Ion Transport and Storage Capacity
published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.8b07102
Daniel Lee, Sachin R. Chaudhari, GaÃ«l De PaÃ«pe
Solvent signal suppression for high-resolution MAS-DNP
published pages: 60-66, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2017.03.012
|Journal of Magnetic Resonance 278||2019-03-18|
Ildefonso Marin-Montesinos, David Goyard, Emilie Gillon, Olivier Renaudet, Anne Imberty, Sabine Hediger, GaÃ«l De PaÃ«pe
Selective High-resolution DNP-enhanced NMR of Biomolecular Binding Sites
published pages: , ISSN: 2041-6520, DOI: 10.1039/c8sc05696j
FrÃ©dÃ©ric Mentink-Vigier, Ildefonso Marin-Montesinos, Anil P. Jagtap, Thomas Halbritter, Johan van Tol, Sabine Hediger, Daniel Lee, Snorri Th. Sigurdsson, GaÃ«l De PaÃ«pe
Computationally Assisted Design of Polarizing Agents for Dynamic Nuclear Polarization Enhanced NMR: The AsymPol Family
published pages: 11013-11019, ISSN: 0002-7863, DOI: 10.1021/jacs.8b04911
|Journal of the American Chemical Society 140/35||2019-03-20|
Adam N. Smith, Katharina MÃ¤rker, Talia Piretra, Jennifer C. Boatz, Irina Matlahov, Ravindra Kodali, Sabine Hediger, Patrick C. A. van der Wel, GaÃ«l De PaÃ«pe
Structural Fingerprinting of Protein Aggregates by Dynamic Nuclear Polarization-Enhanced Solid-State NMR at Natural Isotopic Abundance
published pages: 14576-14580, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09002
|Journal of the American Chemical Society 140/44||2019-03-11|
FrÃ©dÃ©ric Mentink-Vigier, Anne-Laure Barra, Johan van Tol, Sabine Hediger, Daniel Lee, GaÃ«l De PaÃ«pe
De novo prediction of cross-effect efficiency for magic angle spinning dynamic nuclear polarization
published pages: 2166-2176, ISSN: 1463-9076, DOI: 10.1039/c8cp06819d
|Physical Chemistry Chemical Physics 21/4||2019-03-18|
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