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SYNTRAIN SIGNED

Targeting SYNthetic lethal interactions for new cancer treatments TRAINing network

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SYNTRAIN project word cloud

Explore the words cloud of the SYNTRAIN project. It provides you a very rough idea of what is the project "SYNTRAIN" about.

individual combining lethal normal enhances syntrain innovate industry takes mutations consisting bridging techniques world discovery train exceeds screening complementary excellent genome educate therapeutic synthetic advantage young instability pioneered health academic genetic inactivated entrepreneurial investigations repair kill etn cells structured sme basic creative clinically academia cancer members career beneficiary frame acquired inherent critical facetted consists redundant pursue interactions ovarian gene mass capacities genes preparing gap mechanistic brca2 sparing combinations training death prospects drug lethality skills inactivating mutation constitute treatments innovative scientific breast generation pharma capacity stress maintenance dna expertise cell serious compound

Project "SYNTRAIN" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.syntrain.ku.dk
Total cost	3˙990˙269 €
EC max contribution	3˙990˙269 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	580˙163.00
2	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	546˙575.00
3	KANCERA AB KANCERA AB Organization address address: BANVAKTSVAGEN 22 KAROLINSKA INSTITUTET SCIENCE PARK city: SOLNA postcode: 171 48 website: www.kancera.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SOLNA)	participant	527˙318.00
4	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	527˙318.00
5	STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Organization address address: PLESMANLAAN 121 city: AMSTERDAM postcode: 1066 CX website: www.nki.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	510˙748.00
6	KRAEFTENS BEKAEMPELSE KRAEFTENS BEKAEMPELSE Organization address address: STRANDBOULEVARDEN 49 city: KOEBENHAVN postcode: 2100 website: http://www.cancer.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOEBENHAVN)	participant	290˙081.00
7	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	265˙226.00
8	IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE Organization address address: VIA ADAMELLO 16 city: MILANO postcode: 20139 website: www.ifom-firc.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	258˙061.00
9	ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Organization address address: 6 CHRISTOU LADA STR city: ATHINA postcode: 10561 website: www.elke.uoa.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	242˙386.00
10	PANEPISTIMIO PATRON PANEPISTIMIO PATRON Organization address address: UNIVERSITY CAMPUS RIO PATRAS city: RIO PATRAS postcode: 265 04 website: www.upatras.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (RIO PATRAS)	participant	242˙386.00
11	MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN Organization address address: FRANKFURTER STRASSE 250 city: DARMSTADT postcode: 64293 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DARMSTADT)	partner	0.00
12	MISVIK BIOLOGY OY MISVIK BIOLOGY OY Organization address address: KARJAKATU 35 B city: TURKU postcode: 20520 website: www.misvik.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TURKU)	partner	0.00
13	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	partner	0.00

Map

Project objective

Breast and ovarian cancer constitute serious health challenges in the EU. To identify new improved cancer therapeutic approaches, we will pursue a multi-facetted synthetic lethal approach, which takes advantage of the inherent genetic instability of cancer cells. Most mutations acquired by cancer cells do not cause lethality, but the very same mutations may cause cell death when a second gene in a redundant pathway is inactivated. Thus, targeting a gene that is synthetic lethal together with a cancer-specific mutation will kill only cancer cells while sparing normal cells. Synthetic lethal approaches have been clinically pioneered by members of our consortium, by combining cancer-promoting mutations (e.g. in BRCA2) with inactivating combinations of DNA repair genes. We will use this approach as the scientific frame for our ETN (SYNTRAIN) consisting of 9 academic and 1 SME beneficiary as well as 3 partners. We aim to identify synthetic lethal interactions and exploit them to innovate future breast and ovarian cancer treatments through compound screening and development. SYNTRAIN consists of World leading researchers with complementary knowledge in genome maintenance and stress response pathways, and a critical mass of expertise for providing an excellent training in screening methodologies, mechanistic investigations, and drug discovery. We will offer a structured training program that exceeds the capacities of each individual member. We will educate a future generation of cancer researchers with a high innovative capacity and skills that enhances their career prospects in both academia and industry. Our aims are to train young researchers: i) in techniques preparing for a career in cancer research, ii) in complementary skills relevant for work in academia and the pharma industry and iii) to become creative and entrepreneurial, capable of bridging the gap between basic and applied research.

Deliverables

List of deliverables.
SYNTRAIN website	Websites, patent fillings, videos etc.	2019-07-18 19:16:30

Take a look to the deliverables list in detail: detailed list of SYNTRAIN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Timo ReislÃ¤nder, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo LondoÃ±o-Vallejo, Madalena Tarsounas BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11048-5	Nature Communications 10/1	2020-03-05
2018	Panagiotis Galanos, George Pappas, Alexander Polyzos, Athanassios Kotsinas, Ioanna Svolaki, Nickolaos N. Giakoumakis, Christina Glytsou, Ioannis S. Pateras, Umakanta Swain, Vassilis L. Souliotis, Alexandros G. Georgakilas, Nicholas Geacintov, Luca Scorrano, Claudia Lukas, Jiri Lukas, Zvi Livneh, Zoi Lygerou, Dipanjan Chowdhury, Claus Storgaard SÃ¸rensen, Jiri Bartek, Vassilis G. Gorgoulis Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-018-1401-9	Genome Biology 19/1	2019-07-18
2018	Eirini-Stavroula Komseli, Ioannis S. Pateras, ThorbjÃ¸rn Krejsgaard, Konrad Stawiski, Sophia V. Rizou, Alexander Polyzos, Fani-Marlen Roumelioti, Maria Chiourea, Ioanna Mourkioti, Eleni Paparouna, Christos P. Zampetidis, Sentiljana Gumeni, Ioannis P. Trougakos, Dafni-Eleftheria Pefani, Eric Oâ€™Neill, Sarantis Gagos, Aristides G. Eliopoulos, Wojciech Fendler, Dipanjan Chowdhury, Jiri Bartek, Vassilis G. Gorgoulis A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence published pages: 37-58, ISSN: 1471-2164, DOI: 10.1186/s12864-017-4375-1	BMC Genomics 19/1	2019-07-18

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