Train2Target SIGNED
An integrated mulTidisciplinary appRoach towards a new generAtIon of aNtibiotics: Targeting function and cross-talk of bacterial Envelope proTein machineries
Total Cost €
0EC-Contrib. €
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Project "Train2Target" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITA DEGLI STUDI DI MILANO
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | https://www.train2target.eu/ |
| Total cost | 3˙931˙378 € |
| EC max contribution | 3˙931˙378 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2016 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
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Project objective
Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens.
The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads.
The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification.
Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.
Deliverables
| SB and SAB established | Other | 2020-01-24 15:00:40 |
| Website | Websites, patent fillings, videos etc. | 2020-01-24 15:00:40 |
| Industry course | Other | 2020-01-24 15:00:40 |
Take a look to the deliverables list in detail: detailed list of Train2Target deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria published pages: 17981-17990, ISSN: 0021-9258, DOI: 10.1074/jbc.R117.802512 |
Journal of Biological Chemistry 292/44 | 2020-01-24 |
| 2018 |
Cedric Laguri, Alba Silipo, Alessandra M. Martorana, Paul Schanda, Roberta Marchetti, Alessandra Polissi, Antonio Molinaro, Jean-Pierre Simorre Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin published pages: 2106-2113, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00271 |
ACS Chemical Biology 13/8 | 2020-01-24 |
| 2018 |
Katharina Peters, Manuel Pazos, Zainab Edoo, Jean-Emmanuel Hugonnet, Alessandra M. Martorana, Alessandra Polissi, Michael S. VanNieuwenhze, Michel Arthur, Waldemar Vollmer Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins published pages: 10786-10791, ISSN: 0027-8424, DOI: 10.1073/pnas.1809285115 |
Proceedings of the National Academy of Sciences 115/42 | 2020-01-24 |
| 2019 |
Nils Y. Meiresonne, Elisa Consoli, Laureen M. Y. Mertens, Anna Chertkova, Joachim Goedhart, Tanneke den Blaauwen Superfolder mTurquoise2 ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets published pages: , ISSN: 0950-382X, DOI: 10.1111/mmi.14206 |
Molecular Microbiology | 2020-01-24 |
| 2019 |
Niccolò Morè, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro Montón Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, Alessandra Polissi Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.02729-18 |
mBio 10/1 | 2020-01-24 |
| 2017 |
Cedric Laguri, Paola Sperandeo, Kevin Pounot, Isabel Ayala, Alba Silipo, Catherine M. Bougault, Antonio Molinaro, Alessandra Polissi, Jean-Pierre Simorre Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-10136-0 |
Scientific Reports 7/1 | 2020-01-24 |
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The information about "TRAIN2TARGET" are provided by the European Opendata Portal: CORDIS opendata.