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Train2Target SIGNED

An integrated mulTidisciplinary appRoach towards a new generAtIon of aNtibiotics: Targeting function and cross-talk of bacterial Envelope proTein machineries

Total Cost €

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EC-Contrib. €

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Partnership

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 Train2Target project word cloud

Explore the words cloud of the Train2Target project. It provides you a very rough idea of what is the project "Train2Target" about.

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Project "Train2Target" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI MILANO 

Organization address
address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122
website: www.unimi.it

contact info
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function: n.a.
email: n.a.
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 Coordinator Country Italy [IT]
 Project website https://www.train2target.eu/
 Total cost 3˙931˙378 €
 EC max contribution 3˙931˙378 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) coordinator 516˙122.00
2    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 546˙575.00
3    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 510˙748.00
4    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 501˙120.00
5    UNION THERAPEUTICS AS DK (HELLERUP) participant 290˙081.00
6    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) participant 273˙287.00
7    BIOVERSYS AG CH (BASEL) participant 265˙226.00
8    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 262˙875.00
9    NAICONS SRL IT (SARONNO VA) participant 258˙061.00
10    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) participant 258˙061.00
11    AICURIS ANTI-INFECTIVE CURES GMBH DE (WUPPERTAL) participant 249˙216.00
12    ACCELOPMENT AG CH (ZUERICH) partner 0.00
13    Antabio SAS FR (LABEGE) partner 0.00
14    Basilea Pharmaceutica Ltd CH (BASEL) partner 0.00
15    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) partner 0.00
16    UNIVERSITAT BASEL CH (BASEL) partner 0.00
17    ZOETIS INTERNATIONAL SERVICES SAS FR (PARIS) partner 0.00

Map

 Project objective

Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver a next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens.

The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads.

The high quality and credibility of our consortium is ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification.

Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.

 Deliverables

List of deliverables.
SB and SAB established Other 2020-01-24 15:00:40
Website Websites, patent fillings, videos etc. 2020-01-24 15:00:40
Industry course Other 2020-01-24 15:00:40

Take a look to the deliverables list in detail:  detailed list of Train2Target deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Paola Sperandeo, Alessandra M. Martorana, Alessandra Polissi
The lipopolysaccharide transport (Lpt) machinery: A nonconventional transporter for lipopolysaccharide assembly at the outer membrane of Gram-negative bacteria
published pages: 17981-17990, ISSN: 0021-9258, DOI: 10.1074/jbc.R117.802512
Journal of Biological Chemistry 292/44 2020-01-24
2018 Cedric Laguri, Alba Silipo, Alessandra M. Martorana, Paul Schanda, Roberta Marchetti, Alessandra Polissi, Antonio Molinaro, Jean-Pierre Simorre
Solid State NMR Studies of Intact Lipopolysaccharide Endotoxin
published pages: 2106-2113, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00271
ACS Chemical Biology 13/8 2020-01-24
2018 Katharina Peters, Manuel Pazos, Zainab Edoo, Jean-Emmanuel Hugonnet, Alessandra M. Martorana, Alessandra Polissi, Michael S. VanNieuwenhze, Michel Arthur, Waldemar Vollmer
Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins
published pages: 10786-10791, ISSN: 0027-8424, DOI: 10.1073/pnas.1809285115
Proceedings of the National Academy of Sciences 115/42 2020-01-24
2019 Nils Y. Meiresonne, Elisa Consoli, Laureen M. Y. Mertens, Anna Chertkova, Joachim Goedhart, Tanneke den Blaauwen
Superfolder mTurquoise2 ox optimized for the bacterial periplasm allows high efficiency in vivo FRET of cell division antibiotic targets
published pages: , ISSN: 0950-382X, DOI: 10.1111/mmi.14206
Molecular Microbiology 2020-01-24
2019 Niccolò Morè, Alessandra M. Martorana, Jacob Biboy, Christian Otten, Matthias Winkle, Carlos K. Gurnani Serrano, Alejandro Montón Silva, Lisa Atkinson, Hamish Yau, Eefjan Breukink, Tanneke den Blaauwen, Waldemar Vollmer, Alessandra Polissi
Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect
published pages: , ISSN: 2150-7511, DOI: 10.1128/mbio.02729-18
mBio 10/1 2020-01-24
2017 Cedric Laguri, Paola Sperandeo, Kevin Pounot, Isabel Ayala, Alba Silipo, Catherine M. Bougault, Antonio Molinaro, Alessandra Polissi, Jean-Pierre Simorre
Interaction of lipopolysaccharides at intermolecular sites of the periplasmic Lpt transport assembly
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-10136-0
Scientific Reports 7/1 2020-01-24

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The information about "TRAIN2TARGET" are provided by the European Opendata Portal: CORDIS opendata.

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