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MMBio SIGNED

Molecular Tools for Nucleic Acid Manipulation for Biological Intervention

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MMBio" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.bioc.cam.ac.uk/hollfelder/Research/mmbio
 Total cost 3˙971˙347 €
 EC max contribution 3˙971˙347 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 546˙575.00
2    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 546˙575.00
3    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 516˙122.00
4    MEDIMMUNE LIMITED UK (CAMBRIDGE) participant 273˙287.00
5    TURUN YLIOPISTO FI (Turku) participant 269˙145.00
6    UNIVERSITAET BERN CH (BERN) participant 265˙226.00
7    ASTRAZENECA AB SE (SODERTAELJE) participant 263˙659.00
8    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 263˙659.00
9    REGION STOCKHOLM SE (STOCKHOLM) participant 263˙659.00
10    UNIVERSITEIT GENT BE (GENT) participant 250˙560.00
11    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 249˙216.00
12    RISE RESEARCH INSTITUTES OF SWEDEN AB SE (BORAS) participant 234˙363.00
13    SP PROCESS DEVELOPMENT AB SE (BORAS) participant 29˙295.00
14    Alzheimer's Research UK UK (LONDON) partner 0.00
15    ANANAS NANOTECH IT (Padova) partner 0.00
16    CAMBRIDGE ENTREPRISE LIMITED UK (CAMBRIDGE) partner 0.00
17    DROP-TECH LTD UK (Cambridge) partner 0.00
18    OLIGOMER SCIENCES AB SE (DJURSHOLM) partner 0.00
19    Synthena CH (BERN) partner 0.00

Map

 Project objective

MMbio will bridge the classically separate disciplines of Chemistry and Biology by assembling leading experts from academia and non-academic partners (industry, technology transfer & science communication) to bring about systems designed to interfere therapeutically with gene expression in living cells. Expertise in nucleic acid synthesis, its molecular recognition and chemical reactivity is combined with drug delivery, cellular biology and experimental medicine. This project represents a concerted effort to make use of a basic and quantitative understanding of chemical interactions to develop and deliver oligonucleotide molecules of utility for therapy. Our chemical biology approach to this field is ambitious in its breadth and represents a unqiues opportunity to educate young scientists across sectorial and disciplinary barriers. Training will naturally encompass a wide range of skills, requiring a joint effort of chemists and biologists to introduce young researchers in a structured way to and array of research methodologies that no single research grouping could provide. The incorporation of early-stage and later stag ebiotechnology enterprises ensures that commercialisation of methodologies as well as the drug development process is covered in this ITN. We hope that MMBio will train scientists able to understand both the biological problem and the chemistry that holds the possible solution and develop original experimental approaches to stimulate European academic and commercial success in this area.

 Deliverables

List of deliverables.
Summer School Other 2020-03-11 15:11:20
Website, ESR webpages and Moodle operational Websites, patent fillings, videos etc. 2020-03-11 15:11:20
Science communication course Other 2020-03-11 15:11:20

Take a look to the deliverables list in detail:  detailed list of MMBio deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Czescik, Zamolo, Darbre, Mancin, Scrimin
Factors Influencing the Activity of Nanozymes in the Cleavage of an RNA Model Substrate
published pages: 2814, ISSN: 1420-3049, DOI: 10.3390/molecules24152814
Molecules 24/15 2020-03-11
2019 Osama Saher, Taavi Lehto, Olof Gissberg, Dhanu Gupta, Oskar Gustafsson, Samir EL Andaloussi, Tamis Darbre, Karin E. Lundin, C. I. Edvard Smith, Rula Zain
Sugar and Polymer Excipients Enhance Uptake and Splice-Switching Activity of Peptide-Dendrimer/Lipid/Oligonucleotide Formulations
published pages: 666, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics11120666
Pharmaceutics 11/12 2020-03-11
2018 Osama Saher, Cristina S.J. Rocha, Eman M. Zaghloul, Oscar P.B. Wiklander, Susanna Zamolo, Marc Heitz, Kariem Ezzat, Dhanu Gupta, Jean-Louis Reymond, Rula Zain, Florian Hollfelder, Tamis Darbre, Karin E. Lundin, Samir EL Andaloussi, C.I. Edvard Smith
Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity
published pages: 29-40, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2018.09.002
European Journal of Pharmaceutics and Biopharmaceutics 132 2020-03-11
2018 Rouven Stulz, Johan Meuller, Dženita Baždarević, Charlotte Wennberg Huldt, Roger Strömberg, Shalini Andersson, Anders Dahlén
A Versatile and Convenient Synthesis of 34 S-Labeled Phosphorothioate Oligonucleotides
published pages: 2114-2119, ISSN: 1439-4227, DOI: 10.1002/cbic.201800417
ChemBioChem 19/19 2020-03-11
2018 Madhuri Hande, Sajal Maity, Tuomas Lönnberg
Palladacyclic Conjugate Group Promotes Hybridization of Short Oligonucleotides
published pages: 1588, ISSN: 1422-0067, DOI: 10.3390/ijms19061588
International Journal of Molecular Sciences 19/6 2020-03-11

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The information about "MMBIO" are provided by the European Opendata Portal: CORDIS opendata.

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