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DanioPattern SIGNED

Development and Evolution of Colour Patterns in Danio species

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DanioPattern project word cloud

Explore the words cloud of the DanioPattern project. It provides you a very rough idea of what is the project "DanioPattern" about.

anal    understand    opportunity    biodiversity    variants    stripe    body    diversity    vertebrate    mutants    conspicuous    environment    evolve    influence    thorough    model    divergent    direct    spectacularly    tested    sequences    biology    mate    pigment    mediated    first    tailfins    lay    genes    displays    lineage    genome    stripes    diversities    kin    junctions    evolutionary    significance    single    chromatophores    interactions    candidate    transcriptomes    communication    fins    closely    animals    mode    exchanging    cas9    pattern    cellular    camouflage    species    mechanisms    evolution    prominent    explore    foundation    recognition    rerio    functions    alternating    genetic    revealed    building    vertebrates    altered    tracing    danio    chromatophore    variation    patterning    blue    natural    golden    patterns    colour    fundamental    zebrafish    organism    sexual    insights    genus    allelic    analysed    molecular    crispr    disease    basis    channels    play   

Project "DanioPattern" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙250˙000 €
 EC max contribution 2˙250˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 2˙250˙000.00

Map

 Project objective

Colour patterns are prominent features of many animals and have important functions in communication such as camouflage, kin recognition and mate selection. Colour patterns are highly variable and evolve rapidly leading to large diversities even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio), a vertebrate model organism for the study of development and disease, displays a conspicuous pattern of alternating blue and golden stripes on the body and on the anal- and tailfins. Mutants with spectacularly altered patterns have been analysed, and novel approaches in lineage tracing have provided first insights into the cellular and molecular basis of colour patterning. These studies revealed that the mechanisms at play are novel and of fundamental interest to the biology of pattern formation. Closely related Danio species have very divergent colour patterns in body and fins offering the unique opportunity to study development and evolution of colour patterns in vertebrates building on the thorough analysis of one model species. Our research in zebrafish will explore the basis of direct interactions between chromatophores mediated by channels and junctions. We will investigate the divergent mode of stripe formation in the fins and the molecular influence of the cellular environment on chromatophore interactions. In closely related Danio species, we will investigate the cellular interactions during pattern formation. We will analyse transcriptomes and genome sequences to identify candidate genes providing the molecular basis for pigment pattern diversity. These candidate genes will be tested by creating mutants and exchanging allelic variants using the CRISPR/Cas9 system. The work will lay the foundation to understand not only the genetic basis of variation in colour pattern formation between Danio species, but also the evolution of biodiversity in other vertebrates.

 Publications

year authors and title journal last update
List of publications.
2020 Anastasia Eskova, Hans Georg Frohnhöfer, Christiane Nüsslein-Volhard, Uwe Irion
Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish
published pages: 298-303.e3, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.11.033
Current Biology 30/2 2020-02-19
2019 Uwe Irion, Christiane Nüsslein-Volhard
The identification of genes involved in the evolution of color patterns in fish
published pages: 31-38, ISSN: 0959-437X, DOI: 10.1016/j.gde.2019.07.002
Current Opinion in Genetics & Development 57 2020-01-28
2018 Andrey Fadeev, Patricia Mendoza-Garcia, Uwe Irion, Jikui Guan, Kathrin Pfeifer, Stephanie Wiessner, Fabrizio Serluca, Ajeet Pratap Singh, Christiane Nüsslein-Volhard, Ruth H. Palmer
ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells
published pages: E630-E638, ISSN: 0027-8424, DOI: 10.1073/pnas.1719137115
Proceedings of the National Academy of Sciences 115/4 2019-04-13

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The information about "DANIOPATTERN" are provided by the European Opendata Portal: CORDIS opendata.

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