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Insights into the role of phages on the bacterial resistome

Total Cost €


EC-Contrib. €






Project "ROPHARE" data sheet

The following table provides information about the project.


Organization address
address: CALLE PIQUERAS 98
postcode: 26006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 254˙480 €
 EC max contribution 254˙480 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-12-26   to  2019-12-25


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION RIOJA SALUD-FRS ES (LOGRONO) coordinator 254˙480.00


 Project objective

There is an imperative need to gain knowledge on the spread and evolution of antimicrobial resistance (AMR). Recent evidence from environmental, animal and human microbial studies shows that AMR is ancient and environments without contact with anthropogenic antibiotics possess abundant AMR genes. Bacteriophages are the most abundant entities in Earth and recent studies provide indirect evidence for the major role of transduction in the dissemination of AMR genes. Hence, phages might be of critical importance for evading one of the bottlenecks (ecological connectivity) that modulates the transmission of AMR genes from natural environments to animal and human biomes. In this proposal, a holistic and multidisciplinary approach that combines molecular genetics, genomics, metagenomics, in-vitro experimental analysis, computational biology, bioinformatics analysis, and modelling will be followed to measure the potential of naturally occurring phages to be vehicles for AMR transmission and spread in environmental systems with different antibiotic selective pressure. This comprehensive approach will allow us to better understand the phage-bacteria interactions that drive the AMR spread in different ecosystems. From this understanding we expect to be able to design and develop new tools for the control of antimicrobial resistance in clinical and veterinary practice as well as in agriculture. This project will contribute to the objectives of the Work Programme by: 1) allowing the researcher to gain new skills and additional training-through-research in phage and phage-bacteria interactions, computational and (meta)genomic analysis; and to become an EU leading specialist in a research field with emerging growth potential; 2) transferring the acquired knowledge to the EU; 3) establish a long-term collaboration between several centres of excellence that will enhance the quality of research of Europe and make it more competitive and attractive for high-profile researchers.


year authors and title journal last update
List of publications.
2020 Pauline C. Göller, Jose M. Haro-Moreno, Francisco Rodriguez-Valera, Martin J. Loessner, Elena Gómez-Sanz
Uncovering a hidden diversity: optimized protocols for the extraction of dsDNA bacteriophages from soil
published pages: , ISSN: 2049-2618, DOI: 10.1186/s40168-020-0795-2
Microbiome 8/1 2020-02-27
2019 Elena Gómez-Sanz, Sara Ceballos, Laura Ruiz-Ripa, Myriam Zarazaga, Carmen Torres
Clonally Diverse Methicillin and Multidrug Resistant Coagulase Negative Staphylococci Are Ubiquitous and Pose Transfer Ability Between Pets and Their Owners
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00485
Frontiers in Microbiology 10 2020-02-27

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The information about "ROPHARE" are provided by the European Opendata Portal: CORDIS opendata.

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