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NGECA SIGNED

REGULATION OF NEURONAL GENE EXPRESSION THROUGH CHROMOSOME ARCHITECTURE

Total Cost €

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EC-Contrib. €

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Partnership

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 NGECA project word cloud

Explore the words cloud of the NGECA project. It provides you a very rough idea of what is the project "NGECA" about.

circuitry    regions    interconnected    largely    influences    conformation    relates    underlies    discover    transcriptional    expression    dendritic    super    activation    govern    synaptic    simultaneously    remarkable    unexplored    complexes    quantify    unbiased    levels    understand    implications    first    genes    microscopy    multiple    precision    contacts    intracellular    critical    performed    molecular    gene    architecture    depolarisation    individual    regulatory    environmental    frequency    plasticity    regulated    dependent    biological    unprecedented    neurons    loci    chromosomal    mechanisms    chromosome    signalling    map    identification    regulation    cell    experimental    manner    genome    interactions    resolution    dimensional    single    editing    rapid    chromosomes    changing    arg    transcription    looping    disrupt    learning    strength    modulation    enhancer    types    adapt    nucleus    genomic    induction    imaging    brain    neuronal    loops    args    promoter   

Project "NGECA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2020-06-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

A remarkable feature of the brain is its ability to adapt to changing environmental conditions. Modulation of synaptic strength and neuronal circuitry underlies experience-dependent learning, and requires widespread changes in gene expression. Following neuronal depolarisation, intracellular signalling results in rapid induction of many activity-regulated genes (ARGs). There are numerous interconnected levels of gene regulation; one critical aspect relates to the three-dimensional conformation of chromosomes within the nucleus. Looping of genes to regulatory regions and to other genes is required for transcriptional activation in other cell types, but remains largely unexplored in neurons. In this proposal, I will investigate how the genome architecture changes during neuronal depolarisation, and how this influences activity-induced transcription and neuronal plasticity. I will first map the genomic interactions of ARGs in neurons before and after depolarisation. This experimental approach will allow identification of enhancer-promoter loops and multi-gene complexes in an unbiased manner. Single-cell imaging studies will be performed to quantify the frequency of interactions across individual neurons. I will use super-resolution microscopy to simultaneously analyse multiple loci with high precision, providing unprecedented detail of gene interactions in response to neuronal activity. Finally, I will use genome editing to disrupt specific chromosomal contacts and evaluate the transcriptional induction of associated genes. I will assess whether loss of genomic contacts affects dendritic growth, a process associated with neuronal plasticity and dependent on ARG induction, to understand the biological implications of chromosome looping. The aim of this project is to discover novel molecular mechanisms that govern transcription during neuronal activation, which is critical in experience-dependent learning.

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The information about "NGECA" are provided by the European Opendata Portal: CORDIS opendata.

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