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NGECA SIGNED

REGULATION OF NEURONAL GENE EXPRESSION THROUGH CHROMOSOME ARCHITECTURE

Total Cost €

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EC-Contrib. €

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Partnership

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 NGECA project word cloud

Explore the words cloud of the NGECA project. It provides you a very rough idea of what is the project "NGECA" about.

influences    gene    simultaneously    changing    complexes    adapt    molecular    underlies    chromosome    signalling    unbiased    genome    intracellular    discover    individual    enhancer    chromosomal    args    loops    depolarisation    remarkable    modulation    understand    nucleus    unprecedented    promoter    quantify    critical    plasticity    levels    dimensional    editing    regulation    expression    induction    dendritic    super    resolution    transcriptional    biological    architecture    chromosomes    genes    identification    manner    regulated    performed    map    brain    neuronal    learning    activation    experimental    neurons    first    dependent    circuitry    rapid    single    genomic    interactions    environmental    regulatory    frequency    relates    conformation    multiple    govern    strength    arg    precision    transcription    synaptic    disrupt    regions    interconnected    microscopy    contacts    loci    largely    unexplored    types    looping    cell    mechanisms    imaging    implications   

Project "NGECA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2020-06-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

A remarkable feature of the brain is its ability to adapt to changing environmental conditions. Modulation of synaptic strength and neuronal circuitry underlies experience-dependent learning, and requires widespread changes in gene expression. Following neuronal depolarisation, intracellular signalling results in rapid induction of many activity-regulated genes (ARGs). There are numerous interconnected levels of gene regulation; one critical aspect relates to the three-dimensional conformation of chromosomes within the nucleus. Looping of genes to regulatory regions and to other genes is required for transcriptional activation in other cell types, but remains largely unexplored in neurons. In this proposal, I will investigate how the genome architecture changes during neuronal depolarisation, and how this influences activity-induced transcription and neuronal plasticity. I will first map the genomic interactions of ARGs in neurons before and after depolarisation. This experimental approach will allow identification of enhancer-promoter loops and multi-gene complexes in an unbiased manner. Single-cell imaging studies will be performed to quantify the frequency of interactions across individual neurons. I will use super-resolution microscopy to simultaneously analyse multiple loci with high precision, providing unprecedented detail of gene interactions in response to neuronal activity. Finally, I will use genome editing to disrupt specific chromosomal contacts and evaluate the transcriptional induction of associated genes. I will assess whether loss of genomic contacts affects dendritic growth, a process associated with neuronal plasticity and dependent on ARG induction, to understand the biological implications of chromosome looping. The aim of this project is to discover novel molecular mechanisms that govern transcription during neuronal activation, which is critical in experience-dependent learning.

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The information about "NGECA" are provided by the European Opendata Portal: CORDIS opendata.

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