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InterWiring SIGNED

Wiring up the SomatoSensory Cortex

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

InterWiring project word cloud

Explore the words cloud of the InterWiring project. It provides you a very rough idea of what is the project "InterWiring" about.

thalamic dysfunction fundamental functional insights genes despite significantly performed laid originates neural modern acquires unlike incoming modes nuclei sensory arealization clinically wiring progenitors interact transfer neuronal contributor data pathologies mechanisms markedly question mammalian consist place little centers network healthy hope stage cortical respective excitatory cortices biology receive correct modalities construct considering flow cortex functions circuit inputs regions period understanding plethora signaling direct circuits cells bind associative sheet gap plasticity basic inhibitory neuropsychiatric disorders shaped individual etiology bridging neurodevelopmental positioned brain develops embryogenesis starting primary shape critical environment

Project "InterWiring" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: Zürich postcode: 8006 website: http://www.unizh.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	1˙970˙000 €
EC max contribution	1˙970˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2021-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: Zürich postcode: 8006 website: http://www.unizh.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Zürich)	coordinator	1˙970˙000.00

Map

Project objective

Understanding how the mammalian brain network acquires its ability during development to process information and interact with the environment is one of the fundamental challenges in modern biology. The brain originates from a sheet of neural progenitors during embryogenesis but rapidly develops into distinct functional areas such as primary sensory and the highly associative cortices. Although all cortical areas consist of the same main neuronal elements, excitatory and inhibitory cells, their functions are markedly distinct. Unlike others, primary sensory cortical regions receive direct inputs from the environment through the respective thalamic nuclei starting at an early stage in development and are therefore likely to be shaped by incoming activity from sensory modalities. Despite the plethora of data on the arealization of the cortex by early signaling centers and the critical period plasticity mechanisms which take place after the basic elements of the circuit have been laid out, very little is known about the important period in between and how individual elements bind together to construct a functional circuit. This proposal is aimed at bridging this gap in knowledge, by addressing the long-standing question of how genes and activity interact during development to establish the correct wiring of excitatory and inhibitory cells in cortical sensory areas. As the primary role of inhibitory cells is to shape the flow of information transfer in the brain, they are well positioned to contribute significantly to the distinct modes of information processing performed in different cortical areas. Considering that dysfunction of cortical inhibitory circuits has been proposed as a major contributor to the etiology of neuropsychiatric-neurodevelopmental disorders, it is my hope that this approach will not only provide insights into the making of the healthy brain, but also into clinically relevant pathologies.

Publications

List of publications.
year	authors and title	journal	last update
2019	Asim Iqbal, Romesa Khan, Theofanis Karayannis Developing a brain atlas through deep learning published pages: 277-287, ISSN: 2522-5839, DOI: 10.1038/s42256-019-0058-8	Nature Machine Intelligence 1/6	2019-09-26
2019	Fabian F. Voigt, Daniel Kirschenbaum, Evgenia Platonova, StÃ©phane PagÃ¨s, Robert A. A. Campbell, Rahel Kastli, Martina Schaettin, Ladan Egolf, Alexander van der Bourg, Philipp Bethge, Karen Haenraets, NoÃ©mie FrÃ©zel, Thomas Topilko, Paola Perin, Daniel Hillier, Sven Hildebrand, Anna Schueth, Alard Roebroeck, Botond Roska, Esther T. Stoeckli, Roberto Pizzala, Nicolas Renier, Hanns Ulrich Zeilhofe The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue published pages: , ISSN: 1548-7091, DOI: 10.1038/s41592-019-0554-0	Nature Methods	2019-09-26
2019	Asim Iqbal, Asfandyar Sheikh, Theofanis Karayannis DeNeRD: high-throughput detection of neurons for brain-wide analysis with deep learning published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-50137-9	Scientific Reports	2019-09-26

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The information about "INTERWIRING" are provided by the European Opendata Portal: CORDIS opendata.