BACSIN

Bacterial Abiotic Cellular Stress and Survival Improvement Network

 Coordinatore UNIVERSITE DE LAUSANNE 

 Organization address city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Jan Roelof
Cognome: Van Der Meer
Email: send email
Telefono: +41 21 692 5630
Fax: +41 21 692 5605

 Nazionalità Coordinatore Switzerland [CH]
 Sito del progetto http://www.unil.ch/bacsin/
 Totale costo 7˙355˙860 €
 EC contributo 5˙530˙090 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-1
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-06-01   -   2012-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE

 Organization address city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Jan Roelof
Cognome: Van Der Meer
Email: send email
Telefono: +41 21 692 5630
Fax: +41 21 692 5605

CH (LAUSANNE) coordinator 0.00
2    AECOM CZ SRO

 Organization address address: Trojska 92
city: PRAGUE 7
postcode: 171 00

contact info
Titolo: Dr.
Nome: Vendulka
Cognome: Spiskova
Email: send email
Telefono: +420 28 309 0643
Fax: +420 28 309 0658

CZ (PRAGUE 7) participant 0.00
3    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Ms.
Nome: María Del Mar
Cognome: García
Email: send email
Telefono: +34 91 585 4984
Fax: +34 91 411 3077

ES (MADRID) participant 0.00
4    BELAIR BIOTECH Ltd

 Organization address address: Rue des bains
city: GENEVA 8
postcode: 1211

contact info
Titolo: Mr.
Nome: Roland
Cognome: Gerber
Telefono: +41 22 322 24 24
Fax: +41 22 322 24 00

CH (GENEVA 8) participant 0.00
5    BIO-ILIBERIS RESEARCH AND DEVELOPMENT

 Organization address address: "Avenida de la Innovación 1, Parque Tecnológico de Ciencias de la Salud"
city: GRANADA
postcode: 18100

contact info
Titolo: Ms.
Nome: Estrella
Cognome: Ramos
Email: send email
Telefono: +34 694 40 8375
Fax: -+34 958 13 5740

ES (GRANADA) participant 0.00
6    ECOENGINEERING

 Organization address address: Kestenova
city: NOVA VAS (POREC)
postcode: 52440

contact info
Titolo: Dr.
Nome: Vice
Cognome: šoljan
Email: send email
Telefono: +385 52 456 271
Fax: +385 52 456 280

HR (NOVA VAS (POREC)) participant 0.00
7    GOETEBORGS UNIVERSITET

 Organization address address: VASAPARKEN
city: GOETEBORG
postcode: 405 30

contact info
Titolo: Dr.
Nome: Margareta
Cognome: Ahlqwist
Email: send email
Telefono: +46 31 786 5345
Fax: -+46 31 786 2599

SE (GOETEBORG) participant 0.00
8    HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH

 Organization address address: Inhoffenstrasse 7
city: BRAUNSCHWEIG
postcode: 38124

contact info
Titolo: Dr.
Nome: Michael
Cognome: Strätz
Email: send email
Telefono: +49 531 618 12020
Fax: +49 531 618 12299

DE (BRAUNSCHWEIG) participant 0.00
9    HELMHOLTZ-ZENTRUM FUER UMWELTFORSCHUNG GMBH - UFZ

 Organization address address: Permoser Strasse 15
city: LEIPZIG
postcode: 4318

contact info
Titolo: Ms.
Nome: Annette
Cognome: Schmidt
Email: send email
Telefono: +49 341 235 2067
Fax: +49 341 235 2054

DE (LEIPZIG) participant 0.00
10    JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

 Organization address address: Rue de la Loi 200
city: BRUSSELS
postcode: 1049

contact info
Titolo: Dr.
Nome: Arminda
Cognome: Machado
Email: send email
Telefono: +39 033 27 85940
Fax: +39 033 27 85438

BE (BRUSSELS) participant 0.00
11    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Maria
Cognome: Vereeken
Email: send email
Telefono: +32 16 32 6504
Fax: +32 16 32 6515

BE (LEUVEN) participant 0.00
12    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

 Organization address address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV

contact info
Nome: Erwin A
Cognome: Van De Ridder
Email: send email
Telefono: +31 294 23 9378
Fax: +31 294 23 2224

NL (AMSTERDAM) participant 0.00
13    SVERIGES LANTBRUKSUNIVERSITET

 Organization address address: ARRHENIUSPLAN 4
city: UPPSALA
postcode: 75007

contact info
Titolo: Ms.
Nome: Ingrid
Cognome: Ragnarsdotter
Email: send email
Telefono: +46 18 67 1437
Fax: +46 18 67 3537

SE (UPPSALA) participant 0.00
14    TECHNISCHE UNIVERSITAT BRAUNSCHWEIG

 Organization address address: POCKELSSTRASSE 14
city: BRAUNSCHWEIG
postcode: 38106

contact info
Titolo: Prof.
Nome: Kenneth
Cognome: Timmis
Email: send email
Telefono: +49 531 6181 4000
Fax: +49 531 6181 4199

DE (BRAUNSCHWEIG) participant 0.00
15    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Mr.
Nome: Jaap
Cognome: Roos
Email: send email
Telefono: +31 20 598 7234

NL (AMSTERDAM) participant 0.00
16    WAGENINGEN UNIVERSITY

 Organization address address: DROEVENDAALSESTEEG 4
city: WAGENINGEN
postcode: 6708 PB

contact info
Titolo: Mr.
Nome: Frank
Cognome: Bosscha
Email: send email
Telefono: +31 317 48 5965

NL (WAGENINGEN) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

contaminant    rational    biodegradation    degradation    bacsins    pole    treatment    degrading    abiotic    contaminated    microbial    active    pollution    strains    stresses    roots    stress    communities    environment    bacteria    formulations    environments    pollutant    basis    resident    bacsin    catalytic    plant    microbes    successful    cell    sites    superior    good    leaves    molecular    survival    cellular    catabolic    bacterial    site    environmental    resistance    international    polluted    biology    isolation   

 Obiettivo del progetto (Objective)

'BACSIN is a 16-member consortium with the main focus to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of environmental pollution. Current application of bacteria in the environment is hindered by the lack of knowledge on the effects of stresses on cellular activity, most importantly abiotic stresses prevailing on site (e.g., desiccation or nutrient starvation), stresses as a result of pollution itself (e.g., toxicity), and those during strain preparation and formulation. BACSIN proposes four iterative poles of research and technology to overcome this hindrance for subsequent improved microbial usage. The 1st pole will investigate genome-wide catabolic and stress expression in a set of different pollutant degrading bacteria (the ‘BACSINs’). Key cellular factors and regulatory networks determining the interplay between stress-survival and pollutant catabolism will be unveiled, and faithful predictive models for cell behaviour produced. The 2nd pole will study stress resistance, survival and activity of BACSINs in real polluted environments, via microcosms and in situ ‘traps’, plant roots and leaves, while accentuating possible effects on native communities. The 3d pole will focus on the original microbial communities at contaminated sites, to discover and exploit more optimal stress and survival resistance among resident pollutant-degrading bacteria. We will develop molecular diagnostics tools to screen contaminated sites for catabolic and stress parameters, and decide whether BACSIN complementation should be considered. Promising isolates of resident bacteria will be studied as new BACSINs, to show the usefulness of the ‘diagnosis-isolation-reintroduction’ approach for enhancing pollutant biodegradation rates. Finally, we will focus on BACSIN formulations, to understand the stresses on bacteria during growth, preservation and resuscitation, and to produce optimally active cells for environmental application.'

Introduzione (Teaser)

Specific bacterial strains are used for targeted biodegradation in polluted sites. An EU project has outlined the molecular basis of their secret of success under environmentally stressful conditions.

Descrizione progetto (Article)

The EU-funded BACSIN (Bacterial abiotic cellular stress and survival improvement network) project investigated the environmental survival regimes of a number of bacterial strains with good catabolic potential (so-called bacsins). Systems biology, single cell microbiology, classical genetics and modelling all contributed to a holistic picture of bacsin biology under stress.

Bacterial strains were selected on the basis of target pollutants including alkanes and chlorophenols. Their preferred ecological niches were tested to assess behaviour under a range of exposures and environments. Membrane changes, synthesis of compatible solutes or operation of parallel and redundant metabolic pathways were all active in the microbes' survival arsenal.

Microcosm studies using plant leaves, plant roots, soils, sediments, marine beaches, biofilms and reactors showed clearly which strains have superior survival ability. Emphasis was placed on formulations that would enable the microbes to fulfil their degradation function.

Site tests involved a catabolic gene chip and corresponding protocol developed by BACSIN. After extensive testing at varying locations and by different operators, two areas of decontamination were successful. Rhizoremediation using a combination of planting and inoculation with bacsins was a successful strategy for petroleum-contaminated sites. Vermiculite-formulated bacsins gave good degradation results in chlorophenol-contaminated soil.

Surprisingly, more abundant strains isolated at polluted sites presumed to be superior survivors were not so superior after all. However, most of the preselected bacsins survived and aided contaminant degradation during field trials. The conclusion is that pretesting will reveal the most appropriate bacsin for survival and aid in contaminant degradation.

Particular highlights for dissemination included the http://www.bacsin.org (project website), an international student summer course in July 2011 in Lausanne and a final international symposium on rational use of bacteria for bioaugmentation in April 2012 in Amsterdam. Around 60 papers have been published in peer-reviewed journals.

These findings, together with the isolation of natural bacsins from environmental sites, stand to improve the exploitation of bacterial catalytic activities for targeted pollution treatment. Implementation of the Bacsin findings at contaminated sites could improve biodegradation with obvious benefits for the environment.

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