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Vanrestrep SIGNED

Vancomycin resistance regulation in the antibiotic-producers streptomycetes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Vanrestrep project word cloud

Explore the words cloud of the Vanrestrep project. It provides you a very rough idea of what is the project "Vanrestrep" about.

antimicrobial    isolated    last    critical    cluster    clinical    wall    concentration    spread    pathogens    came    defects    enterococcus    antisense    van    understand    bacterial    cell    origin    nutrient    strain    region    lacking    phosphate    glycopeptides    infections    aureus    shown    small    concentrations       promoter    synthesis    influenced    nutritional    staphylococcus    limited    ramp    coding    resort    blocked    antibiotics    acquired    platforms    resistance    pathogen    lab    health    srnas    faecium    induction    regulatory    model    vansr    resistant    treatment    sco2594    salas    excellent    nutrients    opportunity    issue    repression    hospital    mechanisms    producers    genes    streptomyces    gene    vancomycin    actinomycetes    rna    regulates    players    expand    srna    clusters    regulation    whilst    putative    coelicolor    vr    pi    worryingly    skills    aac    suggesting    actinomycete    helping    researcher    natural    antibiotic    pipeline    mutant    medium    therapy    located   

Project "Vanrestrep" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE OVIEDO 

Organization address
address: CALLE SAN FRANCISCO 3
city: OVIEDO
postcode: 33003
website: www.uniovi.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE OVIEDO ES (OVIEDO) coordinator 158˙121.00

Map

 Project objective

Antimicrobial resistance is a critical health issue today. Important pathogens have become resistant to many or all available antibiotics and limited new antibiotics are in the pipeline. Vancomycin is used as a ‘last resort’ antibiotic treatment for many bacterial infections, but worryingly vancomycin resistance (VR) has spread to major hospital-acquired pathogens such as Enterococcus faecium and Staphylococcus aureus. Most pathogen VR gene clusters likely came from actinomycetes, the natural producers of glycopeptides and most other antibiotics of natural origin. Induction of VR in the model actinomycete Streptomyces coelicolor is highly influenced by nutritional conditions, in particular by the phosphate (Pi) concentration in the medium. My previous work has shown that VR in S. coelicolor is blocked with Pi concentrations above 0.2%; suggesting a key role of this nutrient in VR repression. Furthermore, I have isolated a mutant strain (SCO2594::aac(3)IV) lacking this Pi control over VR. This mutant has cell wall synthesis defects and up-regulates a putative small non-coding RNA (sRNA) located in the promoter region of the vanSR regulatory genes. This project aims to understand the mechanisms of Pi regulation of the S. coelicolor van cluster, and to expand this study to other nutrients that may also control VR. A main focus is on the role of sRNAs in the regulation, as they offer potential novel targets for future clinical exploitation such as “antisense RNA therapy”. The work also aims to understand the role of SCO2594 in VR and to identify new players involved in the process. The proposed project represents an excellent opportunity for the researcher to develop new skills whilst helping to ramp up the development of new antimicrobial platforms in the Salas lab.

 Publications

year authors and title journal last update
List of publications.
2018 Fernando Santos-Beneit
Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4838-z
BMC Genomics 19/1 2019-05-03

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The information about "VANRESTREP" are provided by the European Opendata Portal: CORDIS opendata.

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