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Vanrestrep SIGNED

Vancomycin resistance regulation in the antibiotic-producers streptomycetes

Total Cost €


EC-Contrib. €






 Vanrestrep project word cloud

Explore the words cloud of the Vanrestrep project. It provides you a very rough idea of what is the project "Vanrestrep" about.

antisense    shown    helping    srnas    gene    resistant    medium    mechanisms    staphylococcus    regulates    wall    regulatory    srna    excellent    issue    suggesting    came    vancomycin    skills    players    concentration    sco2594    hospital    synthesis    influenced    enterococcus    ramp    infections    coelicolor    aac    pathogen    putative    promoter    limited    clinical    antibiotic    nutritional    blocked    vansr    understand    natural    salas    nutrients    isolated    located    cell    producers    spread    clusters    van    vr    regulation    concentrations    health    region    repression    pipeline    strain    actinomycetes    antibiotics    last    therapy    pi    platforms    defects    lab    coding    genes    pathogens    worryingly    bacterial    resistance    mutant    expand    whilst    treatment    origin    lacking    glycopeptides    acquired    critical    small    nutrient    actinomycete    induction    resort    streptomyces    antimicrobial    faecium    model    rna    opportunity    phosphate    cluster    researcher    aureus      

Project "Vanrestrep" data sheet

The following table provides information about the project.


Organization address
city: OVIEDO
postcode: 33003

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE OVIEDO ES (OVIEDO) coordinator 158˙121.00


 Project objective

Antimicrobial resistance is a critical health issue today. Important pathogens have become resistant to many or all available antibiotics and limited new antibiotics are in the pipeline. Vancomycin is used as a ‘last resort’ antibiotic treatment for many bacterial infections, but worryingly vancomycin resistance (VR) has spread to major hospital-acquired pathogens such as Enterococcus faecium and Staphylococcus aureus. Most pathogen VR gene clusters likely came from actinomycetes, the natural producers of glycopeptides and most other antibiotics of natural origin. Induction of VR in the model actinomycete Streptomyces coelicolor is highly influenced by nutritional conditions, in particular by the phosphate (Pi) concentration in the medium. My previous work has shown that VR in S. coelicolor is blocked with Pi concentrations above 0.2%; suggesting a key role of this nutrient in VR repression. Furthermore, I have isolated a mutant strain (SCO2594::aac(3)IV) lacking this Pi control over VR. This mutant has cell wall synthesis defects and up-regulates a putative small non-coding RNA (sRNA) located in the promoter region of the vanSR regulatory genes. This project aims to understand the mechanisms of Pi regulation of the S. coelicolor van cluster, and to expand this study to other nutrients that may also control VR. A main focus is on the role of sRNAs in the regulation, as they offer potential novel targets for future clinical exploitation such as “antisense RNA therapy”. The work also aims to understand the role of SCO2594 in VR and to identify new players involved in the process. The proposed project represents an excellent opportunity for the researcher to develop new skills whilst helping to ramp up the development of new antimicrobial platforms in the Salas lab.


year authors and title journal last update
List of publications.
2018 Fernando Santos-Beneit
Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4838-z
BMC Genomics 19/1 2019-05-03

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The information about "VANRESTREP" are provided by the European Opendata Portal: CORDIS opendata.

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