EU H2020 Project "VANRESTREP (Vancomycin resistance regulation in the antibiotic-producers streptomycetes)": description, partecipants, costs and EC-fundings

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Vanrestrep project word cloud

Explore the words cloud of the Vanrestrep project. It provides you a very rough idea of what is the project "Vanrestrep" about.

glycopeptides repression isolated cluster aac actinomycetes worryingly mutant nutrient wall mechanisms phosphate coding antimicrobial excellent putative whilst located bacterial acquired expand induction platforms actinomycete region cell rna limited treatment streptomyces promoter regulatory srnas strain hospital ramp influenced vancomycin coelicolor issue resort genes medium came researcher antibiotics health small therapy salas resistant 2 critical nutritional last defects antisense opportunity synthesis nutrients aureus clinical sco2594 concentration resistance model helping vansr concentrations producers understand natural antibiotic enterococcus players regulates faecium pi pipeline vr pathogen lab spread srna regulation skills blocked gene staphylococcus suggesting van clusters infections lacking shown pathogens origin

Project "Vanrestrep" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE OVIEDO Organization address address: CALLE SAN FRANCISCO 3 city: OVIEDO postcode: 33003 website: www.uniovi.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-02-01 to 2020-01-31

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE OVIEDO	ES (OVIEDO)	coordinator	158˙121.00

UNIVERSIDAD DE OVIEDO

ES (OVIEDO)

coordinator

158˙121.00

Project objective

Antimicrobial resistance is a critical health issue today. Important pathogens have become resistant to many or all available antibiotics and limited new antibiotics are in the pipeline. Vancomycin is used as a ‘last resort’ antibiotic treatment for many bacterial infections, but worryingly vancomycin resistance (VR) has spread to major hospital-acquired pathogens such as Enterococcus faecium and Staphylococcus aureus. Most pathogen VR gene clusters likely came from actinomycetes, the natural producers of glycopeptides and most other antibiotics of natural origin. Induction of VR in the model actinomycete Streptomyces coelicolor is highly influenced by nutritional conditions, in particular by the phosphate (Pi) concentration in the medium. My previous work has shown that VR in S. coelicolor is blocked with Pi concentrations above 0.2%; suggesting a key role of this nutrient in VR repression. Furthermore, I have isolated a mutant strain (SCO2594::aac(3)IV) lacking this Pi control over VR. This mutant has cell wall synthesis defects and up-regulates a putative small non-coding RNA (sRNA) located in the promoter region of the vanSR regulatory genes. This project aims to understand the mechanisms of Pi regulation of the S. coelicolor van cluster, and to expand this study to other nutrients that may also control VR. A main focus is on the role of sRNAs in the regulation, as they offer potential novel targets for future clinical exploitation such as “antisense RNA therapy”. The work also aims to understand the role of SCO2594 in VR and to identify new players involved in the process. The proposed project represents an excellent opportunity for the researcher to develop new skills whilst helping to ramp up the development of new antimicrobial platforms in the Salas lab.

Publications

List of publications.
year	authors and title	journal	last update
2018	Fernando Santos-Beneit Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4838-z	BMC Genomics 19/1	2019-05-03

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