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CholAminCo SIGNED

Synergy and antagonism of cholinergic and dopaminergic systems in associative learning

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CholAminCo" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES 

Organization address
address: Szigony utca 43
city: Budapest
postcode: 1083
website: www.koki.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Total cost 1˙499˙463 €
 EC max contribution 1˙499˙463 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES HU (Budapest) coordinator 1˙499˙463.00

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 Project objective

Neuromodulators such as acetylcholine and dopamine are able to rapidly reprogram neuronal information processing and dynamically change brain states. Degeneration or dysfunction of cholinergic and dopaminergic neurons can lead to neuropsychiatric conditions like schizophrenia and addiction or cognitive diseases such as Alzheimer’s. Neuromodulatory systems control overlapping cognitive processes and often have similar modes of action; therefore it is important to reveal cooperation and competition between different systems to understand their unique contributions to cognitive functions like learning, memory and attention. This is only possible by direct comparison, which necessitates monitoring multiple neuromodulatory systems under identical experimental conditions. Moreover, simultaneous recording of different neuromodulatory cell types goes beyond phenomenological description of similarities and differences by revealing the underlying correlation structure at the level of action potential timing. However, such data allowing direct comparison of neuromodulatory actions are still sparse. As a first step to bridge this gap, I propose to elucidate the unique versus complementary roles of two “classical” neuromodulatory systems, the cholinergic and dopaminergic projection system implicated in various cognitive functions including associative learning and plasticity. First, we will record optogenetically identified cholinergic and dopaminergic neurons simultaneously using chronic extracellular recording in mice undergoing classical and operant conditioning. Second, we will determine the postsynaptic impact of cholinergic and dopaminergic neurons by manipulating them both separately and simultaneously while recording consequential changes in cortical neuronal activity and learning behaviour. These experiments will reveal how major neuromodulatory systems interact to mediate similar or different aspects of the same cognitive functions.

 Publications

year authors and title journal last update
List of publications.
2019 András Széll, Sergio Martínez-Bellver, Panna Hegedüs, Balázs Hangya
OPETH: Open Source Solution for Real-time Peri-event Time Histogram Based on Open Ephys
published pages: , ISSN: , DOI: 10.1101/783688
bioRxiv 2019-11-22
2019 Panna Hegedüs, Sergio Martínez-Bellver, Balázs Hangya
Guardians of the learning gate
published pages: 1747-1748, ISSN: 1097-6256, DOI: 10.1038/s41593-019-0519-8
Nature Neuroscience 22/11 2019-11-22
2019 Tamás Laszlovszky, Dániel Schlingloff, Tamás F. Freund, Attila Gulyás, Adam Kepecs, Balázs Hangya
Distinct synchronization, cortical coupling and behavioural function of basal forebrain cholinergic neuron types
published pages: , ISSN: , DOI: 10.1101/703090
bioRxiv 2019-11-22
2018 Nicola Solari, Katalin Sviatkó, Tamás Laszlovszky, Panna Hegedüs, Balázs Hangya
Open Source Tools for Temporally Controlled Rodent Behavior Suitable for Electrophysiology and Optogenetic Manipulations
published pages: , ISSN: 1662-5137, DOI: 10.3389/fnsys.2018.00018
Frontiers in Systems Neuroscience 12 2019-02-11
2018 Nicola Solari, Balázs Hangya
Cholinergic modulation of spatial learning, memory and navigation
published pages: 2199-2230, ISSN: 0953-816X, DOI: 10.1111/ejn.14089
European Journal of Neuroscience 48/5 2019-02-11

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