Opendata, web and dolomites

CONNEXIO SIGNED

Physiologically relevant microfluidic neuro-engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CONNEXIO project word cloud

Explore the words cloud of the CONNEXIO project. It provides you a very rough idea of what is the project "CONNEXIO" about.

lensfree    neurodegenerative    basic    global    localized    spiking    populations    huntington    model    microfluidic    observation    calcium    dimensions    types    vitro    microfluidics    free    ways    tuned    external    connectivity    labelling    reproduce    experimental    brain    diseases    circuitry    deposition    implied    parkinson    decipher    view    physiological    grow    constantly    incubo    neuron    label    observe    developing    lens    neurons    monitoring    neuro    chip    technique    stimulations    compartmentalized    patterning    transduce    densities    drugs    neurites    seeded    neural    fabricate    primary    minimalistic    answer    chambers    chips    networks    oscillators    loop    optical    neuroscience    disruptive    differences    fundamental    compare    connected    network    individual    microgrooves    engineer    manipulated    engineering    computational    platform    functional    clinically    resolution    entire    biological    connectivities    pattern    observing    electrical    combining   

Project "CONNEXIO" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙727˙731 €
 EC max contribution 1˙727˙731 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙727˙731.00

Map

 Project objective

Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. This project aims to address two major challenges: to design and fabricate in vitro biological neural networks that are organized in physiological relevant ways and to provide a label-free monitoring platform capable of observing neural activity both at the neuron resolution and at large fields of view. To do so, the project will develop a unique microfluidic compartmentalized chips where populations of primary neurons will be seeded in deposition chambers with physiological relevant number and densities. Chambers will be connected by microgrooves in which neurites only can grow and whose dimensions will be tuned according to the connectivity pattern to reproduce. To observe the activity of such complex neural networks, we will develop a disruptive observation technique that will transduce the electrical activity of spiking neurons into optical differences observed on a lens-free platform, without calcium labelling and constantly in-incubo. By combining neuro-engineering patterning and the lens-free platform, we will compare individual spiking to global oscillators in basic neural networks under localized external stimulations. Such results will provide experimental insight into computational neuroscience current approaches. Finally, we will design an in vitro network that will reproduce a neural loop implied in major neurodegenerative diseases with physiological relevant neural types, densities and connectivities. This circuitry will be manipulated in order to model Huntington and Parkinson diseases on the chip and assess the impact of known drugs on the functional activity of the entire network. This project will engineer microfluidics chips with physiological relevant neural network and a lensfree activity monitoring platform to answer fundamental and clinically relevant issues in neuroscience.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CONNEXIO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CONNEXIO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More