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CONNEXIO SIGNED

Physiologically relevant microfluidic neuro-engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CONNEXIO project word cloud

Explore the words cloud of the CONNEXIO project. It provides you a very rough idea of what is the project "CONNEXIO" about.

clinically    network    neurons    types    dimensions    functional    tuned    neurodegenerative    reproduce    primary    model    diseases    fabricate    observing    grow    brain    huntington    neural    engineering    chip    densities    technique    physiological    electrical    manipulated    basic    microgrooves    patterning    lens    engineer    transduce    connected    loop    combining    lensfree    fundamental    decipher    view    vitro    optical    implied    answer    compare    circuitry    differences    individual    ways    connectivity    drugs    developing    neuron    disruptive    neuroscience    resolution    entire    labelling    parkinson    constantly    connectivities    global    microfluidics    pattern    localized    incubo    biological    calcium    experimental    observation    neurites    microfluidic    computational    monitoring    deposition    compartmentalized    external    populations    label    neuro    platform    minimalistic    chips    seeded    spiking    stimulations    free    oscillators    chambers    networks    observe   

Project "CONNEXIO" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙727˙731 €
 EC max contribution 1˙727˙731 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙727˙731.00

Map

 Project objective

Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. This project aims to address two major challenges: to design and fabricate in vitro biological neural networks that are organized in physiological relevant ways and to provide a label-free monitoring platform capable of observing neural activity both at the neuron resolution and at large fields of view. To do so, the project will develop a unique microfluidic compartmentalized chips where populations of primary neurons will be seeded in deposition chambers with physiological relevant number and densities. Chambers will be connected by microgrooves in which neurites only can grow and whose dimensions will be tuned according to the connectivity pattern to reproduce. To observe the activity of such complex neural networks, we will develop a disruptive observation technique that will transduce the electrical activity of spiking neurons into optical differences observed on a lens-free platform, without calcium labelling and constantly in-incubo. By combining neuro-engineering patterning and the lens-free platform, we will compare individual spiking to global oscillators in basic neural networks under localized external stimulations. Such results will provide experimental insight into computational neuroscience current approaches. Finally, we will design an in vitro network that will reproduce a neural loop implied in major neurodegenerative diseases with physiological relevant neural types, densities and connectivities. This circuitry will be manipulated in order to model Huntington and Parkinson diseases on the chip and assess the impact of known drugs on the functional activity of the entire network. This project will engineer microfluidics chips with physiological relevant neural network and a lensfree activity monitoring platform to answer fundamental and clinically relevant issues in neuroscience.

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The information about "CONNEXIO" are provided by the European Opendata Portal: CORDIS opendata.

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