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CONNEXIO SIGNED

Physiologically relevant microfluidic neuro-engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CONNEXIO project word cloud

Explore the words cloud of the CONNEXIO project. It provides you a very rough idea of what is the project "CONNEXIO" about.

global    basic    reproduce    chambers    resolution    external    constantly    drugs    neural    connectivity    oscillators    stimulations    observe    pattern    spiking    neuroscience    electrical    loop    patterning    huntington    monitoring    densities    optical    network    dimensions    vitro    answer    physiological    ways    computational    developing    functional    parkinson    view    calcium    seeded    types    compartmentalized    free    microgrooves    microfluidic    minimalistic    observation    neuron    differences    neurites    platform    transduce    deposition    connected    disruptive    grow    incubo    combining    neurodegenerative    compare    labelling    biological    neurons    networks    diseases    implied    microfluidics    engineering    chips    experimental    brain    lensfree    engineer    lens    fabricate    neuro    individual    primary    fundamental    connectivities    tuned    clinically    decipher    circuitry    populations    label    model    observing    entire    manipulated    localized    chip    technique   

Project "CONNEXIO" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙727˙731 €
 EC max contribution 1˙727˙731 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙727˙731.00

Map

 Project objective

Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. This project aims to address two major challenges: to design and fabricate in vitro biological neural networks that are organized in physiological relevant ways and to provide a label-free monitoring platform capable of observing neural activity both at the neuron resolution and at large fields of view. To do so, the project will develop a unique microfluidic compartmentalized chips where populations of primary neurons will be seeded in deposition chambers with physiological relevant number and densities. Chambers will be connected by microgrooves in which neurites only can grow and whose dimensions will be tuned according to the connectivity pattern to reproduce. To observe the activity of such complex neural networks, we will develop a disruptive observation technique that will transduce the electrical activity of spiking neurons into optical differences observed on a lens-free platform, without calcium labelling and constantly in-incubo. By combining neuro-engineering patterning and the lens-free platform, we will compare individual spiking to global oscillators in basic neural networks under localized external stimulations. Such results will provide experimental insight into computational neuroscience current approaches. Finally, we will design an in vitro network that will reproduce a neural loop implied in major neurodegenerative diseases with physiological relevant neural types, densities and connectivities. This circuitry will be manipulated in order to model Huntington and Parkinson diseases on the chip and assess the impact of known drugs on the functional activity of the entire network. This project will engineer microfluidics chips with physiological relevant neural network and a lensfree activity monitoring platform to answer fundamental and clinically relevant issues in neuroscience.

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The information about "CONNEXIO" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2025-05-02 17:53:48) correctly updated