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MADIA SIGNED

Magnetic DIagnostic Assay for neurodegenerative diseases

Total Cost €

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EC-Contrib. €

0

Partnership

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 MADIA project word cloud

Explore the words cloud of the MADIA project. It provides you a very rough idea of what is the project "MADIA" about.

functionalization    trustfully    ultrasensitive    diseases    debilitating    downstream    disease    society    care    annum    faced    close    untreatable    bonding    operate    ensured    parkinson    bio    tool    dementia    vicinity    sensors    small    age    burden    magnetic    magnetoresistive    magnitude    core    incurable    130    sensitive    linked    chemical    madia    diagnostic    flexibility    functionalizing    disorders    realizing    blood    bm    operation    labels    versatile    assay    fluids    greatest    sensor    distances    injected    plan    vitro    largely    dementias    responsible    societal    flowing    quantitatively    protein    pd    trigger    cerebrospinal    body    fluid    neurodegenerative    detectable    mnp    least    sensitivities    microfluidic    scales    medical    grafted    micro    disorder    followed    orders    billion    nanoparticles    alzheimer    people    nano    ad    detection    channels    ultra    consists    mnps    worldwide    surface    groups    complexes    recognition    cheap    device    highlight    nd    csf    concentrations    microfluidics    embodies    complexation    biomarkers    million    amongst    recognizing   

Project "MADIA" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.madia-project.eu/
 Total cost 3˙891˙062 €
 EC max contribution 3˙891˙062 € (100%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2016-1
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 701˙412.00
2    UNIVERSITY OF BRIGHTON UK (BRIGHTON) participant 530˙986.00
3    UNIVERSITAET BIELEFELD DE (BIELEFELD) participant 400˙000.00
4    SCRIBA NANOTECNOLOGIE SRL IT (BOLOGNA) participant 390˙687.00
5    FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI IT (ROMA) participant 383˙250.00
6    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 358˙420.00
7    ORTHOKEY ITALIA SRL IT (CARRARA MS) participant 332˙437.00
8    BIODEVICE SYSTEMS SRO CZ (PRAHA) participant 292˙796.00
9    INNOVA SRL IT (ROMA) participant 251˙500.00
10    SERVIZO GALEGO DE SAUDE ES (Santiago de Compostela) participant 249˙572.00
11    I+ SRL IT (FIRENZE) participant 0.00

Map

 Project objective

MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device, ultra–small Magnetic Nanoparticles (MNPs) and advanced bio-chemical functionalization methods for the early and ultrasensitive. in vitro detection of biomarkers trustfully associated with 2 incurable neurodegenerative diseases: Alzheimer’s Disease (AD) and Parkinson Disease (PD). We plan to achieve sensitivities at least three orders of magnitude higher than best state-of-the-art values flexibility to operate for a wide range of concentrations. WHY: Neurodegenerative diseases (ND) are debilitating and largely untreatable conditions that are strongly linked with age. Amongst these disorders, the dementias are responsible for the greatest burden of disease, with Alzheimer’s disease and related disorders affecting some 7 million people in Europe. The current costs of the order of €130 billion per annum to care for people with dementia across Europe highlight age-related neurodegenerative disease as one of the largest medical and societal challenges faced by our society. PD is the second most common neurodegenerative disorder worldwide after AD. WHAT: The operation principle behind the proposed tool embodies a Magnetic Sensor Assay approach and consists of recognizing the targeted core and downstream biomarkers obtained from body fluids (such as cerebrospinal fluid - CSF and blood) through their complexation with nano-magnetic labels (MNPs) followed by a highly sensitive magnetic detection at micro-scales. The specific recognition of the protein by the magnetic nanoparticles will be achieved and ensured via protein bonding to functionalizing groups grafted on the surface of the MNP. The complexes MNP-BM will be injected into microfluidics channels flowing in the close vicinity of magnetic sensors, bringing thus the MNP-BM to distances where the magnetic field of the MNP will trigger a quantitatively detectable sensor response.

 Deliverables

List of deliverables.
Definition of the best MNP shells for aptamer selectivity Documents, reports 2020-04-24 00:48:01
Data and samples collection from AD and PD patients Documents, reports 2020-04-24 00:48:01
Dissemination and training plan Documents, reports 2020-04-24 00:48:01
Magneto-microfluidic detection unit assembled Documents, reports 2020-04-24 00:48:01
Project website Other 2020-04-24 00:48:01
Content management system - CMS Documents, reports 2020-04-24 00:48:01

Take a look to the deliverables list in detail:  detailed list of MADIA deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Maria Serena Chiriacò, Andrea Luvisi, Elisabetta Primiceri, Erika Sabella, Luigi De Bellis, Giuseppe Maruccio
Development of a lab-on-a-chip method for rapid assay of Xylella fastidiosa subsp. pauca strain CoDiRO
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25747-4
Scientific Reports 8/1 2020-04-24
2017 Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D\'Onofrio, Antonino Cattaneo
ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00020
Frontiers in Molecular Neuroscience 10 2020-04-24
2018 Marco Terrigno, Irene Busti, Claudia Alia, Marta Pietrasanta, Ivan Arisi, Mara D\'Onofrio, Matteo Caleo, Federico Cremisi
Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain
published pages: 1016-1029, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.010
Stem Cell Reports 10/3 2020-04-24
2017 Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro
\"Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies\"
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.17371
Oncotarget 8/39 2020-04-24
2017 Valentina Latina, Silvia Caioli, Cristina Zona, Maria T. Ciotti, Giuseppina Amadoro, Pietro Calissano
Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00068
Frontiers in Cellular Neuroscience 11 2020-04-24
2017 Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano
The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology
published pages: 1319, ISSN: 1422-0067, DOI: 10.3390/ijms18061319
International Journal of Molecular Sciences 18/6 2020-04-24
2017 Z. Vargas-Osorio, M. A. González-Gómez, Y. Piñeiro, C. Vázquez-Vázquez, C. Rodríguez-Abreu, M. A. López-Quintela, J. Rivas
Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe 3 O 4 ) as potential multifunctional theranostic nanodevices
published pages: 9395-9404, ISSN: 2050-7518, DOI: 10.1039/C7TB01963G
Journal of Materials Chemistry B 5/47 2020-04-24

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