MADIA SIGNED
Magnetic DIagnostic Assay for neurodegenerative diseases
Total Cost €
0EC-Contrib. €
0Partnership
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0MADIA project word cloud
Explore the words cloud of the MADIA project. It provides you a very rough idea of what is the project "MADIA" about.
Project "MADIA" data sheet
The following table provides information about the project.
| Coordinator |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | http://www.madia-project.eu/ |
| Total cost | 3˙891˙062 € |
| EC max contribution | 3˙891˙062 € (100%) |
| Programme |
1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)) |
| Code Call | H2020-ICT-2016-1 |
| Funding Scheme | RIA |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CONSIGLIO NAZIONALE DELLE RICERCHE | IT (ROMA) | coordinator | 701˙412.00 |
| 2 | UNIVERSITY OF BRIGHTON | UK (BRIGHTON) | participant | 530˙986.00 |
| 3 | UNIVERSITAET BIELEFELD | DE (BIELEFELD) | participant | 400˙000.00 |
| 4 | SCRIBA NANOTECNOLOGIE SRL | IT (BOLOGNA) | participant | 390˙687.00 |
| 5 | FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI | IT (ROMA) | participant | 383˙250.00 |
| 6 | UNIVERSIDAD DE SANTIAGO DE COMPOSTELA | ES (SANTIAGO DE COMPOSTELA) | participant | 358˙420.00 |
| 7 | ORTHOKEY ITALIA SRL | IT (CARRARA MS) | participant | 332˙437.00 |
| 8 | BIODEVICE SYSTEMS SRO | CZ (PRAHA) | participant | 292˙796.00 |
| 9 | INNOVA SRL | IT (ROMA) | participant | 251˙500.00 |
| 10 | SERVIZO GALEGO DE SAUDE | ES (Santiago de Compostela) | participant | 249˙572.00 |
| 11 | I+ SRL | IT (FIRENZE) | participant | 0.00 |
Map
Project objective
MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device, ultra–small Magnetic Nanoparticles (MNPs) and advanced bio-chemical functionalization methods for the early and ultrasensitive. in vitro detection of biomarkers trustfully associated with 2 incurable neurodegenerative diseases: Alzheimer’s Disease (AD) and Parkinson Disease (PD). We plan to achieve sensitivities at least three orders of magnitude higher than best state-of-the-art values flexibility to operate for a wide range of concentrations. WHY: Neurodegenerative diseases (ND) are debilitating and largely untreatable conditions that are strongly linked with age. Amongst these disorders, the dementias are responsible for the greatest burden of disease, with Alzheimer’s disease and related disorders affecting some 7 million people in Europe. The current costs of the order of €130 billion per annum to care for people with dementia across Europe highlight age-related neurodegenerative disease as one of the largest medical and societal challenges faced by our society. PD is the second most common neurodegenerative disorder worldwide after AD. WHAT: The operation principle behind the proposed tool embodies a Magnetic Sensor Assay approach and consists of recognizing the targeted core and downstream biomarkers obtained from body fluids (such as cerebrospinal fluid - CSF and blood) through their complexation with nano-magnetic labels (MNPs) followed by a highly sensitive magnetic detection at micro-scales. The specific recognition of the protein by the magnetic nanoparticles will be achieved and ensured via protein bonding to functionalizing groups grafted on the surface of the MNP. The complexes MNP-BM will be injected into microfluidics channels flowing in the close vicinity of magnetic sensors, bringing thus the MNP-BM to distances where the magnetic field of the MNP will trigger a quantitatively detectable sensor response.
Deliverables
| Definition of the best MNP shells for aptamer selectivity | Documents, reports | 2020-04-24 00:48:01 |
| Data and samples collection from AD and PD patients | Documents, reports | 2020-04-24 00:48:01 |
| Dissemination and training plan | Documents, reports | 2020-04-24 00:48:01 |
| Magneto-microfluidic detection unit assembled | Documents, reports | 2020-04-24 00:48:01 |
| Project website | Other | 2020-04-24 00:48:01 |
| Content management system - CMS | Documents, reports | 2020-04-24 00:48:01 |
Take a look to the deliverables list in detail: detailed list of MADIA deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Maria Serena Chiriacò, Andrea Luvisi, Elisabetta Primiceri, Erika Sabella, Luigi De Bellis, Giuseppe Maruccio Development of a lab-on-a-chip method for rapid assay of Xylella fastidiosa subsp. pauca strain CoDiRO published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25747-4 |
Scientific Reports 8/1 | 2020-04-24 |
| 2017 |
Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D\'Onofrio, Antonino Cattaneo ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00020 |
Frontiers in Molecular Neuroscience 10 | 2020-04-24 |
| 2018 |
Marco Terrigno, Irene Busti, Claudia Alia, Marta Pietrasanta, Ivan Arisi, Mara D\'Onofrio, Matteo Caleo, Federico Cremisi Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain published pages: 1016-1029, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.010 |
Stem Cell Reports 10/3 | 2020-04-24 |
| 2017 |
Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro \"Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies\" published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.17371 |
Oncotarget 8/39 | 2020-04-24 |
| 2017 |
Valentina Latina, Silvia Caioli, Cristina Zona, Maria T. Ciotti, Giuseppina Amadoro, Pietro Calissano Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00068 |
Frontiers in Cellular Neuroscience 11 | 2020-04-24 |
| 2017 |
Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology published pages: 1319, ISSN: 1422-0067, DOI: 10.3390/ijms18061319 |
International Journal of Molecular Sciences 18/6 | 2020-04-24 |
| 2017 |
Z. Vargas-Osorio, M. A. González-Gómez, Y. Piñeiro, C. Vázquez-Vázquez, C. RodrÃguez-Abreu, M. A. López-Quintela, J. Rivas Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe 3 O 4 ) as potential multifunctional theranostic nanodevices published pages: 9395-9404, ISSN: 2050-7518, DOI: 10.1039/C7TB01963G |
Journal of Materials Chemistry B 5/47 | 2020-04-24 |
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