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MADIA SIGNED

Magnetic DIagnostic Assay for neurodegenerative diseases

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MADIA project word cloud

Explore the words cloud of the MADIA project. It provides you a very rough idea of what is the project "MADIA" about.

130 operation disease magnetic detectable nd linked largely worldwide care parkinson fluids society protein orders alzheimer fluid vitro small madia complexation ad quantitatively recognition chemical channels scales trigger least flexibility vicinity bio body mnps diagnostic magnitude untreatable biomarkers downstream consists operate detection faced disorders sensor age nanoparticles people concentrations societal microfluidics functionalizing cerebrospinal annum realizing microfluidic ultrasensitive blood highlight trustfully groups billion embodies amongst dementia diseases close medical injected nano followed sensitivities ensured csf ultra distances plan recognizing bonding incurable complexes assay grafted pd disorder million sensors magnetoresistive labels cheap sensitive flowing dementias greatest device core bm debilitating surface mnp functionalization responsible burden neurodegenerative tool micro versatile

Project "MADIA" data sheet

The following table provides information about the project.

Coordinator	CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.madia-project.eu/
Total cost	3˙891˙062 €
EC max contribution	3˙891˙062 € (100%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2016-1
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	701˙412.00
2	UNIVERSITY OF BRIGHTON UNIVERSITY OF BRIGHTON Organization address address: LEWES ROAD MITHRAS HOUSE city: BRIGHTON postcode: BN2 4AT website: www.brighton.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRIGHTON)	participant	530˙986.00
3	UNIVERSITAET BIELEFELD UNIVERSITAET BIELEFELD Organization address address: UNIVERSITAETSSTRASSE 25 city: BIELEFELD postcode: 33615 website: www.uni-bielefeld.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BIELEFELD)	participant	400˙000.00
4	SCRIBA NANOTECNOLOGIE SRL SCRIBA NANOTECNOLOGIE SRL Organization address address: VIA DI CORTICELLA 183/8 city: BOLOGNA postcode: 40128 website: www.scriba-nanotec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	390˙687.00
5	FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI FONDAZIONE EUROPEAN BRAIN RESEARCHINSTITUTE RITA LEVI Organization address address: VIA REGINA ELENA 295 city: ROMA postcode: 161 website: www.ebri.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	383˙250.00
6	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	participant	358˙420.00
7	ORTHOKEY ITALIA SRL ORTHOKEY ITALIA SRL Organization address address: PIAZZA NAZIONI UNITE 15 city: CARRARA MS postcode: 54033 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CARRARA MS)	participant	332˙437.00
8	BIODEVICE SYSTEMS SRO BIODEVICE SYSTEMS SRO Organization address address: BULHARSKA 996 20 city: PRAHA postcode: 10100 website: www.biodevicesystems.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA)	participant	292˙796.00
9	INNOVA SRL INNOVA SRL Organization address address: VIA CICERONE, 66 city: ROMA postcode: 193 website: www.innova-eu.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	251˙500.00
10	SERVIZO GALEGO DE SAUDE SERVIZO GALEGO DE SAUDE Organization address address: Edificio Administrativo San Lázaro city: Santiago de Compostela postcode: 15703 website: www.sergas.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Santiago de Compostela)	participant	249˙572.00
11	I+ SRL I+ SRL Organization address address: PIAZZA PUCCINI 26 city: FIRENZE postcode: 50100 website: http://www.i-piu.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FIRENZE)	participant	0.00

Map

Project objective

MADIA aims at realizing a versatile and cheap diagnostic device based on magnetoresistive sensors, microfluidic device, ultra–small Magnetic Nanoparticles (MNPs) and advanced bio-chemical functionalization methods for the early and ultrasensitive. in vitro detection of biomarkers trustfully associated with 2 incurable neurodegenerative diseases: Alzheimer’s Disease (AD) and Parkinson Disease (PD). We plan to achieve sensitivities at least three orders of magnitude higher than best state-of-the-art values flexibility to operate for a wide range of concentrations. WHY: Neurodegenerative diseases (ND) are debilitating and largely untreatable conditions that are strongly linked with age. Amongst these disorders, the dementias are responsible for the greatest burden of disease, with Alzheimer’s disease and related disorders affecting some 7 million people in Europe. The current costs of the order of €130 billion per annum to care for people with dementia across Europe highlight age-related neurodegenerative disease as one of the largest medical and societal challenges faced by our society. PD is the second most common neurodegenerative disorder worldwide after AD. WHAT: The operation principle behind the proposed tool embodies a Magnetic Sensor Assay approach and consists of recognizing the targeted core and downstream biomarkers obtained from body fluids (such as cerebrospinal fluid - CSF and blood) through their complexation with nano-magnetic labels (MNPs) followed by a highly sensitive magnetic detection at micro-scales. The specific recognition of the protein by the magnetic nanoparticles will be achieved and ensured via protein bonding to functionalizing groups grafted on the surface of the MNP. The complexes MNP-BM will be injected into microfluidics channels flowing in the close vicinity of magnetic sensors, bringing thus the MNP-BM to distances where the magnetic field of the MNP will trigger a quantitatively detectable sensor response.

Deliverables

List of deliverables.
Definition of the best MNP shells for aptamer selectivity	Documents, reports	2020-04-24 00:48:01
Data and samples collection from AD and PD patients	Documents, reports	2020-04-24 00:48:01
Dissemination and training plan	Documents, reports	2020-04-24 00:48:01
Magneto-microfluidic detection unit assembled	Documents, reports	2020-04-24 00:48:01
Project website	Other	2020-04-24 00:48:01
Content management system - CMS	Documents, reports	2020-04-24 00:48:01

Take a look to the deliverables list in detail: detailed list of MADIA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Maria Serena ChiriacÃ², Andrea Luvisi, Elisabetta Primiceri, Erika Sabella, Luigi De Bellis, Giuseppe Maruccio Development of a lab-on-a-chip method for rapid assay of Xylella fastidiosa subsp. pauca strain CoDiRO published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25747-4	Scientific Reports 8/1	2020-04-24
2017	Luisa Fasulo, Rossella Brandi, Ivan Arisi, Federico La Regina, Nicola Berretta, Simona Capsoni, Mara D\'Onofrio, Antonino Cattaneo ProNGF Drives Localized and Cell Selective Parvalbumin Interneuron and Perineuronal Net Depletion in the Dentate Gyrus of Transgenic Mice published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00020	Frontiers in Molecular Neuroscience 10	2020-04-24
2018	Marco Terrigno, Irene Busti, Claudia Alia, Marta Pietrasanta, Ivan Arisi, Mara D\'Onofrio, Matteo Caleo, Federico Cremisi Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain published pages: 1016-1029, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.01.010	Stem Cell Reports 10/3	2020-04-24
2017	Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amadoro \"Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies\" published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.17371	Oncotarget 8/39	2020-04-24
2017	Valentina Latina, Silvia Caioli, Cristina Zona, Maria T. Ciotti, Giuseppina Amadoro, Pietro Calissano Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2017.00068	Frontiers in Cellular Neuroscience 11	2020-04-24
2017	Nadia Canu, Giuseppina Amadoro, Viviana Triaca, Valentina Latina, Valentina Sposato, Veronica Corsetti, Cinzia Severini, Maria Teresa Ciotti, Pietro Calissano The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimerâ€™s Disease Neuropathology published pages: 1319, ISSN: 1422-0067, DOI: 10.3390/ijms18061319	International Journal of Molecular Sciences 18/6	2020-04-24
2017	Z. Vargas-Osorio, M. A. GonzÃ¡lez-GÃ³mez, Y. PiÃ±eiro, C. VÃ¡zquez-VÃ¡zquez, C. RodrÃguez-Abreu, M. A. LÃ³pez-Quintela, J. Rivas Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe 3 O 4 ) as potential multifunctional theranostic nanodevices published pages: 9395-9404, ISSN: 2050-7518, DOI: 10.1039/C7TB01963G	Journal of Materials Chemistry B 5/47	2020-04-24

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